Aliases for PRTN3 Gene
External Ids for PRTN3 Gene
Previous GeneCards Identifiers for PRTN3 Gene
GeneCards Summary for PRTN3 Gene
PRTN3 (Proteinase 3) is a Protein Coding gene. Diseases associated with PRTN3 include Granulomatosis With Polyangiitis and Vasculitis. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include enzyme binding and serine-type peptidase activity. An important paralog of this gene is ELANE.
UniProtKB/Swiss-Prot Summary for PRTN3 Gene
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).