Aliases for PRTN3 Gene
External Ids for PRTN3 Gene
Previous GeneCards Identifiers for PRTN3 Gene
GeneCards Summary for PRTN3 Gene
PRTN3 (Proteinase 3) is a Protein Coding gene. Diseases associated with PRTN3 include Granulomatosis With Polyangiitis and Vasculitis. Among its related pathways are C-MYB transcription factor network and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include enzyme binding and serine-type peptidase activity. An important paralog of this gene is ELANE.
UniProtKB/Swiss-Prot Summary for PRTN3 Gene
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).