Aliases for PRSS8 Gene
External Ids for PRSS8 Gene
Previous GeneCards Identifiers for PRSS8 Gene
This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]
GeneCards Summary for PRSS8 Gene
PRSS8 (Serine Protease 8) is a Protein Coding gene. Diseases associated with PRSS8 include Pseudohypoaldosteronism and Ichthyosis, Follicular. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity.
UniProtKB/Swiss-Prot Summary for PRSS8 Gene
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).