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Aliases for PRSS58 Gene

Aliases for PRSS58 Gene

  • Protease, Serine 58 2 3 5
  • Trypsin-X3 3 4
  • TRYX3 3 4
  • TRY1 3 4
  • Serine Protease 58 3
  • EC 4
  • Trypsin X3 2
  • UNQ2540 3
  • PRSS1 3

External Ids for PRSS58 Gene

Previous GeneCards Identifiers for PRSS58 Gene

  • GC07M141952

Summaries for PRSS58 Gene

Entrez Gene Summary for PRSS58 Gene

  • This gene encodes a member of the trypsin family of serine proteases. This gene and several related trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. This gene was previously described as a trypsinogen-like pseudogene, but it is now thought to be a protein-coding gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRSS58 Gene

PRSS58 (Protease, Serine 58) is a Protein Coding gene. Diseases associated with PRSS58 include Pancreas Disease. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS37.

Additional gene information for PRSS58 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS58 Gene

Genomics for PRSS58 Gene

GeneHancer (GH) Regulatory Elements for PRSS58 Gene

Promoters and enhancers for PRSS58 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I142258 Promoter 0.5 EPDnew 550.8 0.0 -20 0.1 PRSS58 TRY2P
GH07I141840 Enhancer 0.2 FANTOM5 26.1 +417.7 417666 0.1 PRSS37 PRSS58 MYL6P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRSS58 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRSS58 Gene

Genomic Locations for PRSS58 Gene
5,921 bases
Minus strand

Genomic View for PRSS58 Gene

Genes around PRSS58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS58 Gene

Proteins for PRSS58 Gene

  • Protein details for PRSS58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease 58
    Protein Accession:
    Secondary Accessions:
    • B3KVJ6
    • D3DXD2

    Protein attributes for PRSS58 Gene

    241 amino acids
    Molecular mass:
    27085 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS58 Gene

Post-translational modifications for PRSS58 Gene

  • Glycosylation at Asn156 and Asn173
  • Modification sites at PhosphoSitePlus

Other Protein References for PRSS58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS58 Gene

Domains & Families for PRSS58 Gene

Gene Families for PRSS58 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRSS58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS58: view

Function for PRSS58 Gene

Molecular function for PRSS58 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Arg- -Xaa, Lys- -Xaa.

Enzyme Numbers (IUBMB) for PRSS58 Gene

Gene Ontology (GO) - Molecular Function for PRSS58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS58: view
genes like me logo Genes that share phenotypes with PRSS58: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS58

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS58 Gene

Localization for PRSS58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS58 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS58 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for PRSS58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PRSS58: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS58 Gene

Pathways & Interactions for PRSS58 Gene

SuperPathways for PRSS58 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRSS58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS58: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS58 Gene

Drugs & Compounds for PRSS58 Gene

No Compound Related Data Available

Transcripts for PRSS58 Gene

mRNA/cDNA for PRSS58 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS58 Gene

Protease, serine, 58:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS58 Gene

No ASD Table

Relevant External Links for PRSS58 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS58 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS58 Gene

This gene is overexpressed in Testis (x51.9).

Protein differential expression in normal tissues from HIPED for PRSS58 Gene

This gene is overexpressed in Testis (36.1) and Ovary (32.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRSS58 Gene

Protein tissue co-expression partners for PRSS58 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRSS58 Gene:


SOURCE GeneReport for Unigene cluster for PRSS58 Gene:


Evidence on tissue expression from TISSUES for PRSS58 Gene

  • Nervous system(4)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with PRSS58: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS58 Gene

Orthologs for PRSS58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS58 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRSS58 34
  • 100 (a)
LOC742071 33
  • 99.72 (n)
(Canis familiaris)
Mammalia LOC475522 33
  • 79.67 (n)
PRSS58 34
  • 70 (a)
(Bos Taurus)
Mammalia PRSS58 33 34
  • 78.65 (n)
(Rattus norvegicus)
Mammalia Prss58 33
  • 76.55 (n)
(Mus musculus)
Mammalia Prss58 33 16 34
  • 75.93 (n)
(Monodelphis domestica)
Mammalia PRSS58 34
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 30 (a)
Species where no ortholog for PRSS58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS58 Gene

Gene Tree for PRSS58 (if available)
Gene Tree for PRSS58 (if available)

Paralogs for PRSS58 Gene

Paralogs for PRSS58 Gene

genes like me logo Genes that share paralogs with PRSS58: view

Variants for PRSS58 Gene

Sequence variations from dbSNP and Humsavar for PRSS58 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000426631 -- 142,258,599(-) T/C upstream_transcript_variant
rs1001208090 -- 142,253,905(-) T/C intron_variant
rs1001284575 -- 142,257,068(-) G/A intron_variant
rs1001302936 -- 142,253,646(-) A/C intron_variant
rs1001864912 -- 142,257,869(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS58 Gene

Variant ID Type Subtype PubMed ID
esv33962 CNV gain+loss 17666407
nsv1018286 CNV gain 25217958
nsv1035111 CNV gain 25217958
nsv465131 CNV loss 19166990
nsv608591 CNV gain 21841781

Variation tolerance for PRSS58 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS58 Gene

Disorders for PRSS58 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRSS58 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pancreas disease
  • abnormality of the pancreas
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PRSS58

genes like me logo Genes that share disorders with PRSS58: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS58 Gene

Publications for PRSS58 Gene

  1. Scan of human genome reveals no new Loci under ancient balancing selection. (PMID: 16751668) Bubb KL … Olson MV (Genetics 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for PRSS58 Gene

Sources for PRSS58 Gene

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