Aliases for PRSS57 Gene
External Ids for PRSS57 Gene
Previous HGNC Symbols for PRSS57 Gene
This gene encodes an arginine-specific serine protease and member of the peptidase S1 family of proteins. The encoded protein may undergo proteolytic activation before storage in azurophil granules, in neutrophil cells of the immune system. Following neutrophil activation, the protease is released into the pericellular environment, where it may play a role in defense against microbial pathogens. [provided by RefSeq, Jul 2016]
GeneCards Summary for PRSS57 Gene
PRSS57 (Serine Protease 57) is a Protein Coding gene. Diseases associated with PRSS57 include Eastern Equine Encephalitis and Western Equine Encephalitis. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is GZMM.
UniProtKB/Swiss-Prot Summary for PRSS57 Gene
Serine protease that cleaves preferentially after Arg residues (PubMed:22474388, PubMed:23904161, PubMed:25156428). Can also cleave after citrulline (deimidated arginine) and methylarginine residues (PubMed:25156428).