This gene encodes a member of a group of membrane-anchored chymotrypsin (S1)-like serine proteases. The enocoded protein is primarily expressed in the Leydig and Sertoli cells of the testis and may be involved in male fertility. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010] See more...

Aliases for PRSS55 Gene

Aliases for PRSS55 Gene

  • Serine Protease 55 2 3 4 5
  • T-SP1 2 3 4
  • Testis Serine Protease 1 3 4
  • Protease, Serine 55 2 3
  • UNQ9391 2 3
  • CT153 2 3
  • TSP1 3 4
  • Probable Serine Protease UNQ9391/PRO34284 3
  • Tryptophan/Serine Protease 3
  • EC 3.4.21.- 4
  • PRSS55 5

External Ids for PRSS55 Gene

Previous GeneCards Identifiers for PRSS55 Gene

  • GC08P010383
  • GC08P009313

Summaries for PRSS55 Gene

Entrez Gene Summary for PRSS55 Gene

  • This gene encodes a member of a group of membrane-anchored chymotrypsin (S1)-like serine proteases. The enocoded protein is primarily expressed in the Leydig and Sertoli cells of the testis and may be involved in male fertility. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

GeneCards Summary for PRSS55 Gene

PRSS55 (Serine Protease 55) is a Protein Coding gene. Diseases associated with PRSS55 include Lymphogranuloma Venereum and Granuloma Inguinale. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLKB1.

UniProtKB/Swiss-Prot Summary for PRSS55 Gene

  • Probable serine protease, which plays a crucial role in the fertility of male mice including sperm migration and sperm-egg interaction.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRSS55 Gene

Genomics for PRSS55 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRSS55 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J010525 Promoter 0.3 EPDnew 250.7 +0.0 32 0.1 PRSS55 piR-58436 lnc-PRSS51-2 PRSS51 lnc-PRSS51-6 HSALNG0063379
GH08J010528 Enhancer 0.8 FANTOM5 Ensembl 15.3 +3.2 3196 0.2 MAFF IRF4 ZNF316 CBFB MAFK BATF MAFG JUNB EZH2 RUNX3 PRSS55 PRSS51 lnc-PRSS51-2 lnc-PRSS51-6 HSALNG0063379
GH08J010545 Enhancer 0.8 Ensembl ENCODE 13.6 +21.4 21385 4 ZNF654 CTCF REST SIN3A RAD21 SMC3 BHLHE40 ZNF2 ZNF189 ZNF143 PRSS51 lnc-PRSS51-2 PRSS55 ENSG00000272505 ENSG00000253678 HSALNG0063379 lnc-PRSS51-6
GH08J010965 Enhancer 0.7 FANTOM5 Ensembl 16.6 +440.3 440317 1.2 EBF1 ZFP91 IKZF1 TCF12 IKZF2 POLR2A HSALNG0063404 piR-60471 C8orf74 PRSS55 ENSG00000254936 PINX1 XKR6
GH08J010599 Enhancer 0.8 Ensembl ENCODE 8.4 +72.9 72917 1.6 JUND ZIC2 FOSL2 TFAP4 HNF4A ZFP69B NFIA ZNF692 FOS IKZF1 PRSS55 HSALNG0063383 PRSS51 MIR4286 C8orf74
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRSS55 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRSS55

Genomic Locations for PRSS55 Gene

Latest Assembly
chr8:10,525,484-10,554,166
(GRCh38/hg38)
Size:
28,683 bases
Orientation:
Plus strand

Previous Assembly
chr8:10,383,042-10,411,676
(GRCh37/hg19 by Entrez Gene)
Size:
28,635 bases
Orientation:
Plus strand

chr8:10,383,056-10,411,676
(GRCh37/hg19 by Ensembl)
Size:
28,621 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr8(PATCHES):2,792,885-2,821,515 (-)

Genomic View for PRSS55 Gene

Genes around PRSS55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS55 Gene

Proteins for PRSS55 Gene

  • Protein details for PRSS55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWB4-PRS55_HUMAN
    Recommended name:
    Serine protease 55
    Protein Accession:
    Q6UWB4
    Secondary Accessions:
    • E5RJX5

    Protein attributes for PRSS55 Gene

    Size:
    352 amino acids
    Molecular mass:
    38856 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRSS55 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRSS55 Gene

Post-translational modifications for PRSS55 Gene

  • Glycosylation at Asn240

Other Protein References for PRSS55 Gene

No data available for DME Specific Peptides for PRSS55 Gene

Domains & Families for PRSS55 Gene

Gene Families for PRSS55 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PRSS55 Gene

InterPro:
Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature

Suggested Antigen Peptide Sequences for PRSS55 Gene

GenScript: Design optimal peptide antigens:
  • Serine protease 55 (PRS55_HUMAN)
  • UNQ9391 protein (Q6P2N5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UWB4

UniProtKB/Swiss-Prot:

PRS55_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS55: view

Function for PRSS55 Gene

Molecular function for PRSS55 Gene

UniProtKB/Swiss-Prot Function:
Probable serine protease, which plays a crucial role in the fertility of male mice including sperm migration and sperm-egg interaction.

Enzyme Numbers (IUBMB) for PRSS55 Gene

Phenotypes From GWAS Catalog for PRSS55 Gene

Gene Ontology (GO) - Molecular Function for PRSS55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS55: view
genes like me logo Genes that share phenotypes with PRSS55: view

Animal Models for PRSS55 Gene

MGI Knock Outs for PRSS55:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS55

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS55 Gene

Localization for PRSS55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS55 Gene

[Isoform 1]: Cell membrane. Lipid-anchor, GPI-anchor. Cytoplasm, cytosol. Note=Mainly found in the membrane part of the cells and only in small amounts in the cytosol. {ECO:0000269 PubMed:18844450}.
[Isoform 2]: Cytoplasm, cytosol. Note=Present primarily in the cytosol and only in minor amounts in the membrane fraction. {ECO:0000269 PubMed:18844450}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS55 gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PRSS55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle ISS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PRSS55: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS55 Gene

Pathways & Interactions for PRSS55 Gene

PathCards logo

SuperPathways for PRSS55 Gene

No Data Available

Interacting Proteins for PRSS55 Gene

Gene Ontology (GO) - Biological Process for PRSS55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007339 binding of sperm to zona pellucida ISS --
GO:0030317 flagellated sperm motility ISS --
genes like me logo Genes that share ontologies with PRSS55: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS55 Gene

Drugs & Compounds for PRSS55 Gene

No Compound Related Data Available

Transcripts for PRSS55 Gene

mRNA/cDNA for PRSS55 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS55

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS55 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: - -
SP2: -

Relevant External Links for PRSS55 Gene

GeneLoc Exon Structure for
PRSS55

Expression for PRSS55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRSS55 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS55 Gene

This gene is overexpressed in Testis (x38.2).

Protein differential expression in normal tissues from HIPED for PRSS55 Gene

This gene is overexpressed in Plasma (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS55 Gene



Protein tissue co-expression partners for PRSS55 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRSS55

SOURCE GeneReport for Unigene cluster for PRSS55 Gene:

Hs.591394

mRNA Expression by UniProt/SwissProt for PRSS55 Gene:

Q6UWB4-PRS55_HUMAN
Tissue specificity: Only detected in testis. Expressed in spermatogonia, spermatocytes, spermatids, Leydig and Sertoli cells. Expressed in prostate cancer and ovarian cancer (at protein level).

Evidence on tissue expression from TISSUES for PRSS55 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PRSS55: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS55 Gene

Orthologs for PRSS55 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS55 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRSS55 29 30
  • 98.33 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PRSS55 29 30
  • 80.18 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prss55 29
  • 73.04 (n)
Mouse
(Mus musculus)
Mammalia Prss55 29 16 30
  • 72.37 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PRSS55 30
  • 61 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PRSS55 30
  • 40 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PRSS55 30
  • 34 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PRSS55 29 30
  • 55.73 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PRSS55 30
  • 33 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta CLIPD3 29
  • 46.75 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG18478 30
  • 27 (a)
ManyToMany
CG31827 30
  • 27 (a)
ManyToMany
CG4259 30
  • 24 (a)
ManyToMany
CG18557 30
  • 23 (a)
ManyToMany
CG3117 30
  • 23 (a)
ManyToMany
CG14990 30
  • 22 (a)
ManyToMany
CG5390 30
  • 20 (a)
ManyToMany
CG9377 30
  • 19 (a)
ManyToMany
CG40160 30
  • 19 (a)
ManyToMany
CG8586 30
  • 19 (a)
ManyToMany
CG13318 30
  • 19 (a)
ManyToMany
CG18563 30
  • 19 (a)
ManyToMany
CG8738 30
  • 17 (a)
ManyToMany
CG6639 30
  • 17 (a)
ManyToMany
CG18477 30
  • 15 (a)
ManyToMany
CG31780 30
  • 15 (a)
ManyToMany
CG4793 30
  • 10 (a)
ManyToMany
scaf 30
  • 10 (a)
ManyToMany
CG4998 30
  • 7 (a)
ManyToMany
Species where no ortholog for PRSS55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PRSS55 Gene

ENSEMBL:
Gene Tree for PRSS55 (if available)
TreeFam:
Gene Tree for PRSS55 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRSS55: view image
Alliance of Genome Resources:
Additional Orthologs for PRSS55

Paralogs for PRSS55 Gene

Paralogs for PRSS55 Gene

Pseudogenes.org Pseudogenes for PRSS55 Gene

genes like me logo Genes that share paralogs with PRSS55: view

Variants for PRSS55 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRSS55 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs78604829 Benign: not provided 10,538,670(+) G/A
NM_198464.4(PRSS55):c.936G>A (p.Arg312=)
SYNONYMOUS_VARIANT,INTRON
rs4406360 -- p.Ala212Val
rs4521726 -- p.Pro44Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PRSS55 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PRSS55 Gene

Variant ID Type Subtype PubMed ID
esv3572508 CNV loss 25503493
nsv1025557 CNV gain 25217958
nsv1026918 CNV loss 25217958
nsv1030934 CNV gain 25217958
nsv610267 CNV gain 21841781
nsv610268 CNV loss 21841781

Variation tolerance for PRSS55 Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.70; 83.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS55 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS55
Leiden Open Variation Database (LOVD)
PRSS55

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS55 Gene

Disorders for PRSS55 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRSS55 Gene - From: COP

Disorder Aliases PubMed IDs
lymphogranuloma venereum
  • climatic or tropical bubo
granuloma inguinale
  • donovanosis
mixed germ cell-sex cord neoplasm
  • mixed germ cell-sex cord tumor
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PRSS55

genes like me logo Genes that share disorders with PRSS55: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS55 Gene

Publications for PRSS55 Gene

  1. T-SP1: a novel serine protease-like protein predominantly expressed in testis. (PMID: 18844450) Neth P … Jochum M (Biological chemistry 2008) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
  3. Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PMID: 23436708) Liu M … Sha J (Proteomics 2013) 3 4
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4

Products for PRSS55 Gene

Sources for PRSS55 Gene