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Aliases for PRSS53 Gene

Aliases for PRSS53 Gene

  • Protease, Serine 53 2 3 5
  • Polyserine Protease 3 3 4
  • Polyserase-3 3 4
  • Serine Protease 53 3
  • Polyserase 3 2
  • EC 3.4.21.- 4
  • EDTP308 3
  • UNQ308 3
  • POL3S 3

External Ids for PRSS53 Gene

Previous GeneCards Identifiers for PRSS53 Gene

  • GC16M028656

Summaries for PRSS53 Gene

GeneCards Summary for PRSS53 Gene

PRSS53 (Protease, Serine 53) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS36.

UniProtKB/Swiss-Prot for PRSS53 Gene

  • In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator.

Additional gene information for PRSS53 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS53 Gene

Genomics for PRSS53 Gene

GeneHancer (GH) Regulatory Elements for PRSS53 Gene

Promoters and enhancers for PRSS53 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I031088 Promoter 0.8 EPDnew 550.8 +1.1 1052 0.1 SMARCA5 POLR2A ZFP36 ZMYM3 PRSS53 GC16P031249 PIR60151 ENSG00000255439
GH16I031090 Enhancer 0.6 ENCODE 550.8 -1.0 -952 0.8 KLF17 ZNF76 ATF2 ZIC2 PATZ1 GLIS1 ZNF600 PRDM10 PRSS53 KAT8 ENSG00000255439 ENSG00000280160 VKORC1
GH16I031093 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.1 -4.6 -4556 4 HDGF PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 VKORC1 ENSG00000255439 ENSG00000280160 SETD1A ZNF785 ZNF720 FUS ZNF689 SRCAP ZNF747
GH16I030872 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE 4.2 +215.2 215150 5.3 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D MIR762HG MIR4519 RNF40 INO80E ENSG00000260267 SETD1A FUS BCL7C FBRS SRCAP
GH16I031084 Enhancer 0.8 ENCODE dbSUPER 7.5 +3.6 3605 4.7 SMARCA5 KLF1 MAZ ZBTB6 KLF17 REST ZIC2 GLIS2 POLR2A GLIS1 GC16P031249 PIR60151 HSD3B7 ENSG00000260911 PRSS53 CD2BP2 ENSG00000255439 ZNF646
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRSS53 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRSS53 Gene

Genomic Locations for PRSS53 Gene
6,612 bases
Minus strand

Genomic View for PRSS53 Gene

Genes around PRSS53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS53 Gene

Proteins for PRSS53 Gene

  • Protein details for PRSS53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease 53
    Protein Accession:

    Protein attributes for PRSS53 Gene

    553 amino acids
    Molecular mass:
    58410 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS53 Gene

Post-translational modifications for PRSS53 Gene

No Post-translational modifications

Other Protein References for PRSS53 Gene

No data available for DME Specific Peptides for PRSS53 Gene

Domains & Families for PRSS53 Gene

Gene Families for PRSS53 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRSS53 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS53: view

Function for PRSS53 Gene

Molecular function for PRSS53 Gene

UniProtKB/Swiss-Prot Function:
In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator.

Enzyme Numbers (IUBMB) for PRSS53 Gene

Phenotypes From GWAS Catalog for PRSS53 Gene

Gene Ontology (GO) - Molecular Function for PRSS53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IBA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS53: view

Phenotypes for PRSS53 Gene

genes like me logo Genes that share phenotypes with PRSS53: view

miRNA for PRSS53 Gene

miRTarBase miRNAs that target PRSS53

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRSS53 Gene

Localization for PRSS53 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS53 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS53 gene
Compartment Confidence
extracellular 4
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PRSS53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with PRSS53: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS53 Gene

Pathways & Interactions for PRSS53 Gene

SuperPathways for PRSS53 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRSS53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS53: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS53 Gene

Drugs & Compounds for PRSS53 Gene

(1) Drugs for PRSS53 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Warfarin Approved Pharma 505
genes like me logo Genes that share compounds with PRSS53: view

Transcripts for PRSS53 Gene

mRNA/cDNA for PRSS53 Gene

(6) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS53 Gene

Protease, serine, 53:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS53 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9

Relevant External Links for PRSS53 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS53 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS53 Gene

Protein differential expression in normal tissues from HIPED for PRSS53 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRSS53 Gene

Protein tissue co-expression partners for PRSS53 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRSS53 Gene:


SOURCE GeneReport for Unigene cluster for PRSS53 Gene:


mRNA Expression by UniProt/SwissProt for PRSS53 Gene:

Tissue specificity: Predominantly detected in testis, liver, heart and ovary, as well as in several tumor cell lines.
genes like me logo Genes that share expression patterns with PRSS53: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS53 Gene

Orthologs for PRSS53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS53 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRSS53 33 34
  • 99.28 (n)
(Canis familiaris)
Mammalia PRSS53 33 34
  • 87.4 (n)
(Bos Taurus)
Mammalia PRSS53 33 34
  • 85.67 (n)
(Mus musculus)
Mammalia Prss53 33 16 34
  • 81.46 (n)
(Rattus norvegicus)
Mammalia Prss53 33
  • 80.45 (n)
(Monodelphis domestica)
Mammalia PRSS53 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia PRSS53 34
  • 69 (a)
(Anolis carolinensis)
Reptilia PRSS53 34
  • 38 (a)
(Danio rerio)
Actinopterygii BX571714.1 34
  • 27 (a)
zgc:92313 34
  • 26 (a)
Species where no ortholog for PRSS53 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS53 Gene

Gene Tree for PRSS53 (if available)
Gene Tree for PRSS53 (if available)

Paralogs for PRSS53 Gene

(18) SIMAP similar genes for PRSS53 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRSS53: view

Variants for PRSS53 Gene

Sequence variations from dbSNP and Humsavar for PRSS53 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs104894542 drug-response, Warfarin response 31,091,243(-) A/C upstream_transcript_variant
rs201075024 benign, Vitamin K-Dependent Clotting Factors 31,087,679(-) C/T coding_sequence_variant, missense_variant
rs7200749 likely-benign, Vitamin K-Dependent Clotting Factors 31,091,268(-) G/A upstream_transcript_variant
rs72547528 pathogenic, Vitamin k-dependent clotting factors, combined deficiency of, 2 31,091,334(-) G/A/C upstream_transcript_variant
rs7294 drug-response, benign, phenprocoumon response - Dosage, warfarin response - Dosage, acenocoumarol response - Dosage, Vitamin K-Dependent Clotting Factors 31,091,000(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS53 Gene

Variant ID Type Subtype PubMed ID
nsv833193 CNV gain+loss 17160897
nsv571820 CNV loss 21841781
nsv457483 CNV loss 19166990
esv993244 CNV deletion 20482838

Variation tolerance for PRSS53 Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.30; 95.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS53 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS53 Gene

Disorders for PRSS53 Gene

Additional Disease Information for PRSS53

No disorders were found for PRSS53 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS53 Gene

Publications for PRSS53 Gene

  1. Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain. (PMID: 16566820) Cal S … López-Otín C (BMC biochemistry 2006) 2 3 4 22 58
  2. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N … PD GWAS Consortium (Annals of neurology 2012) 3 44 58
  3. Genome-wide association analysis identifies three psoriasis susceptibility loci. (PMID: 20953189) Stuart PE … Elder JT (Nature genetics 2010) 3 58
  4. Expanding the complexity of the human degradome: polyserases and their tandem serine protease domains. (PMID: 17485402) Cal S … Lopez-Otin C (Frontiers in bioscience : a journal and virtual library 2007) 22 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 58

Products for PRSS53 Gene

Sources for PRSS53 Gene

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