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Aliases for PRSS50 Gene

Aliases for PRSS50 Gene

  • Protease, Serine 50 2 3 5
  • Cancer/Testis Antigen 20 2 3 4
  • Testis-Specific Protease-Like Protein 50 3 4
  • Serine Protease 50 3 4
  • TSP50 3 4
  • CT20 3 4
  • Probable Threonine Protease PRSS50 3
  • Testicular Tissue Protein Li 210 3
  • Testes Specific Protease 50 2
  • Testes-Specific Protease 50 3
  • EC 3.4.25.- 4

External Ids for PRSS50 Gene

Previous GeneCards Identifiers for PRSS50 Gene

  • GC03M046731

Summaries for PRSS50 Gene

GeneCards Summary for PRSS50 Gene

PRSS50 (Protease, Serine 50) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and threonine-type endopeptidase activity. An important paralog of this gene is TPSB2.

UniProtKB/Swiss-Prot for PRSS50 Gene

  • May be involved in proteolysis through its threonine endopeptidase activity.

Additional gene information for PRSS50 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS50 Gene

Genomics for PRSS50 Gene

GeneHancer (GH) Regulatory Elements for PRSS50 Gene

Promoters and enhancers for PRSS50 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I046717 Promoter 0.9 EPDnew 550.8 +0.0 44 0.1 CTCF KLF1 RB1 SIN3A CTBP1 CBX1 SKIL GMEB1 VEZF1 ZNF143 PRSS50 PRSS45 TMIE
GH03I046690 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 7.3 +23.9 23913 7.2 RB1 NFIB SIN3A ZBTB40 RAD21 YY1 ZNF335 EGR1 ZNF143 RCOR1 ALS2CL TMIE PRSS50 LRRC2 PRSS45
GH03I046564 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 7.6 +151.9 151897 2.8 PKNOX1 FOXA2 MLX ARID4B ZNF48 RAD21 YY1 ZNF335 RCOR1 FOS LRRC2 LTF RTP3 PRSS50 PRSS46P CCRL2 SCAP TDGF1 LRRC2-AS1
GH03I046844 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.5 -128.0 -127974 2.6 SIN3A GLIS2 ZNF143 RUNX3 ZNF263 SP3 REST ZNF518A ZNF610 GMEB1 PRSS45 ALS2CL PTH1R MYL3 PRSS44 PRSS50 LRRC2 PRSS42
GH03I046872 Enhancer 0.4 FANTOM5 dbSUPER 31.8 -154.5 -154455 0.4 PRSS50 PRSS46P KIF9 MYL3 PTH1R PRSS42
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRSS50 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRSS50 Gene

Genomic Locations for PRSS50 Gene
5,793 bases
Minus strand

Genomic View for PRSS50 Gene

Genes around PRSS50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS50 Gene

Proteins for PRSS50 Gene

  • Protein details for PRSS50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable threonine protease PRSS50
    Protein Accession:

    Protein attributes for PRSS50 Gene

    385 amino acids
    Molecular mass:
    43088 Da
    Quaternary structure:
    No Data Available
    • DNA hypomethylation is accompanied by the expression of the gene in the testis.

neXtProt entry for PRSS50 Gene

Post-translational modifications for PRSS50 Gene

  • Glycosylation at isoforms=133 and isoforms=279
  • Modification sites at PhosphoSitePlus

Other Protein References for PRSS50 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS50 Gene

Domains & Families for PRSS50 Gene

Gene Families for PRSS50 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS50: view

Function for PRSS50 Gene

Molecular function for PRSS50 Gene

UniProtKB/Swiss-Prot Function:
May be involved in proteolysis through its threonine endopeptidase activity.

Enzyme Numbers (IUBMB) for PRSS50 Gene

Phenotypes From GWAS Catalog for PRSS50 Gene

Gene Ontology (GO) - Molecular Function for PRSS50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0004298 threonine-type endopeptidase activity IMP 17283160
GO:0008233 peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS50: view
genes like me logo Genes that share phenotypes with PRSS50: view

Animal Models for PRSS50 Gene

MGI Knock Outs for PRSS50:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS50

CRISPR Products

miRNA for PRSS50 Gene

miRTarBase miRNAs that target PRSS50

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRSS50 Gene

Localization for PRSS50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS50 Gene

Endoplasmic reticulum. Note=May also localize to cytoplasmic membranes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS50 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRSS50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17283160
GO:0005783 endoplasmic reticulum IDA,IEA 17283160
genes like me logo Genes that share ontologies with PRSS50: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS50 Gene

Pathways & Interactions for PRSS50 Gene

SuperPathways for PRSS50 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRSS50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 17283160
genes like me logo Genes that share ontologies with PRSS50: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS50 Gene

Drugs & Compounds for PRSS50 Gene

No Compound Related Data Available

Transcripts for PRSS50 Gene

mRNA/cDNA for PRSS50 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS50 Gene

Protease, serine, 50:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS50 Gene

No ASD Table

Relevant External Links for PRSS50 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS50 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS50 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS50 Gene

This gene is overexpressed in Testis (x15.1), Pituitary (x7.5), and Thyroid (x5.2).

Protein differential expression in normal tissues from HIPED for PRSS50 Gene

This gene is overexpressed in Testis (52.2) and Ovary (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRSS50 Gene

Protein tissue co-expression partners for PRSS50 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRSS50 Gene:


SOURCE GeneReport for Unigene cluster for PRSS50 Gene:


mRNA Expression by UniProt/SwissProt for PRSS50 Gene:

Tissue specificity: Testis specific. Differentially expressed in some breast cancer tissues.
genes like me logo Genes that share expression patterns with PRSS50: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS50 Gene

Orthologs for PRSS50 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRSS50 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRSS50 33
  • 99.57 (n)
(Canis familiaris)
Mammalia PRSS50 33
  • 76.52 (n)
(Bos Taurus)
Mammalia PRSS50 33
  • 76.13 (n)
(Rattus norvegicus)
Mammalia LOC100910205 33
  • 74.88 (n)
(Mus musculus)
Mammalia Prss50 33 16
  • 74.54 (n)
Species where no ortholog for PRSS50 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS50 Gene

Gene Tree for PRSS50 (if available)
Gene Tree for PRSS50 (if available)

Paralogs for PRSS50 Gene

Paralogs for PRSS50 Gene

(10) SIMAP similar genes for PRSS50 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRSS50: view

Variants for PRSS50 Gene

Sequence variations from dbSNP and Humsavar for PRSS50 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000042625 -- 46,718,830(-) G/A upstream_transcript_variant
rs1000431829 -- 46,719,036(-) T/C upstream_transcript_variant
rs1000451833 -- 46,714,611(-) A/G intron_variant
rs1001794690 -- 46,714,628(-) C/T intron_variant
rs1002495038 -- 46,716,995(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS50 Gene

Variant ID Type Subtype PubMed ID
esv2759147 CNV loss 17122850
esv3596066 CNV gain 21293372
nsv428417 CNV loss 18775914
nsv516623 CNV loss 19592680
nsv590179 CNV loss 21841781
nsv954478 CNV deletion 24416366

Variation tolerance for PRSS50 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS50 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS50 Gene

Disorders for PRSS50 Gene

Additional Disease Information for PRSS50

No disorders were found for PRSS50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS50 Gene

Publications for PRSS50 Gene

  1. Isolation of a novel gene, TSP50, by a hypomethylated DNA fragment in human breast cancer. (PMID: 10397268) Yuan L … Xu HP (Cancer research 1999) 2 3 4 22 58
  2. Identification and characterization of the human testes-specific protease 50 gene promoter. (PMID: 18462069) Wang M … Li YX (DNA and cell biology 2008) 3 22 58
  3. Differential methylation of TSP50 and mTSP50 genes in different types of human tissues and mouse spermatic cells. (PMID: 18662669) Huang Y … Xu H (Biochemical and biophysical research communications 2008) 3 22 58
  4. TSP50 encodes a testis-specific protease and is negatively regulated by p53. (PMID: 17283160) Xu H … Tian K (Cancer research 2007) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PRSS50 Gene

Sources for PRSS50 Gene

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