Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRSS46P Gene

Aliases for PRSS46P Gene

  • Protease, Serine 46, Pseudogene 2 3
  • Protease, Serine 46 2 3 5
  • PRSS46 3 4 5
  • Putative Serine Protease 46 3
  • Testis Serine Protease 6 3
  • EC 3.4.21.- 4
  • TESSP6 3

External Ids for PRSS46P Gene

Previous HGNC Symbols for PRSS46P Gene

  • PRSS46

Summaries for PRSS46P Gene

GeneCards Summary for PRSS46P Gene

PRSS46P (Protease, Serine 46, Pseudogene) is a Pseudogene. An important paralog of this gene is TPSD1.

Additional gene information for PRSS46P Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS46P Gene

Genomics for PRSS46P Gene

GeneHancer (GH) Regulatory Elements for PRSS46P Gene

Promoters and enhancers for PRSS46P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I046736 Promoter 0.5 EPDnew 550.8 0.0 -18 0.1 PRSS46P PRSS45
GH03I046564 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 7.4 +170.4 170421 2.8 PKNOX1 FOXA2 MLX ARID4B ZNF48 RAD21 YY1 ZNF335 RCOR1 FOS LRRC2 LTF RTP3 PRSS50 PRSS46P CCRL2 SCAP TDGF1 LRRC2-AS1
GH03I046872 Enhancer 0.4 FANTOM5 dbSUPER 31.1 -135.9 -135931 0.4 PRSS50 PRSS46P KIF9 MYL3 PTH1R PRSS42
GH03I047266 Enhancer 1.1 Ensembl ENCODE 11.3 -530.5 -530476 1.1 PKNOX1 SMAD1 TCF12 ZNF766 FOS ATF7 RUNX3 ZNF214 NCOA1 JUNB NBEAL2 PRSS46P KIF9-AS1 SETD2 KLHL18 KIF9 SNORD13P3
GH03I046848 Enhancer 1 Ensembl ENCODE dbSUPER 9.8 -112.8 -112809 1.7 CTCF PKNOX1 ZBTB6 ZNF792 MAX PYGO2 RAD21 NR2F2 ZKSCAN8 ZNF143 PRSS45 ALS2CL PTH1R MYL3 PRSS44 PRSS46P PRSS42
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRSS46P on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRSS46P Gene

Genomic Locations for PRSS46P Gene
chr3:46,719,583-46,736,431
(GRCh38/hg38)
Size:
16,849 bases
Orientation:
Minus strand
chr3:46,761,073-46,777,921
(GRCh37/hg19)

Genomic View for PRSS46P Gene

Genes around PRSS46P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS46P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS46P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS46P Gene

Proteins for PRSS46P Gene

  • Protein details for PRSS46P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E5RG02-PRS46_HUMAN
    Recommended name:
    Putative serine protease 46
    Protein Accession:
    E5RG02

    Protein attributes for PRSS46P Gene

    Size:
    174 amino acids
    Molecular mass:
    19341 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS46P Gene

Post-translational modifications for PRSS46P Gene

No Post-translational modifications

Other Protein References for PRSS46P Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS46P Gene

Domains & Families for PRSS46P Gene

Gene Families for PRSS46P Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PRSS46P Gene

Graphical View of Domain Structure for InterPro Entry

E5RG02

UniProtKB/Swiss-Prot:

PRS46_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS46P: view

No data available for Suggested Antigen Peptide Sequences for PRSS46P Gene

Function for PRSS46P Gene

Enzyme Numbers (IUBMB) for PRSS46P Gene

Phenotypes From GWAS Catalog for PRSS46P Gene

Gene Ontology (GO) - Molecular Function for PRSS46P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS46P: view

Phenotypes for PRSS46P Gene

GenomeRNAi human phenotypes for PRSS46P:
genes like me logo Genes that share phenotypes with PRSS46P: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS46P Gene

Localization for PRSS46P Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS46P gene
Compartment Confidence
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRSS46P Gene

Pathways & Interactions for PRSS46P Gene

SuperPathways for PRSS46P Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRSS46P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS46P: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS46P Gene

Drugs & Compounds for PRSS46P Gene

No Compound Related Data Available

Transcripts for PRSS46P Gene

mRNA/cDNA for PRSS46P Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS46P Gene

No ASD Table

Relevant External Links for PRSS46P Gene

GeneLoc Exon Structure for
PRSS46P
ECgene alternative splicing isoforms for
PRSS46P

Expression for PRSS46P Gene

NURSA nuclear receptor signaling pathways regulating expression of PRSS46P Gene:

PRSS46P
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS46P Gene

Orthologs for PRSS46P Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS46P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS46 33
  • 98.66 (n)
-- 34
  • 17 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC609323 33
  • 81.94 (n)
PRSS46 34
  • 34 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC101907297 33
  • 78.04 (n)
PRSS46 34
  • 36 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prss46 33
  • 76.15 (n)
mouse
(Mus musculus)
Mammalia Prss46 33 16 34
  • 76.05 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 17 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 18 (a)
ManyToMany
-- 34
  • 17 (a)
ManyToMany
Species where no ortholog for PRSS46P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS46P Gene

ENSEMBL:
Gene Tree for PRSS46P (if available)
TreeFam:
Gene Tree for PRSS46P (if available)

Paralogs for PRSS46P Gene

Paralogs for PRSS46P Gene

genes like me logo Genes that share paralogs with PRSS46P: view

Variants for PRSS46P Gene

Sequence variations from dbSNP and Humsavar for PRSS46P Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000910113 -- 46,726,155(-) A/G intron_variant
rs1001037113 -- 46,720,501(-) A/T intron_variant
rs1001297660 -- 46,721,235(-) G/A intron_variant
rs1001425883 -- 46,733,253(-) G/A intron_variant
rs1001448360 -- 46,720,171(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS46P Gene

Variant ID Type Subtype PubMed ID
nsv590179 CNV loss 21841781
nsv516623 CNV loss 19592680
nsv428417 CNV loss 18775914
esv33334 CNV gain 17666407
esv2759147 CNV loss 17122850
dgv4731n100 CNV loss 25217958
dgv4730n100 CNV loss 25217958

Variation tolerance for PRSS46P Gene

Gene Damage Index Score: 7.31; 81.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS46P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS46P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS46P Gene

Disorders for PRSS46P Gene

Additional Disease Information for PRSS46P

No disorders were found for PRSS46P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS46P Gene

Publications for PRSS46P Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for PRSS46P Gene

Sources for PRSS46P Gene

Content
Loading form....