This gene encodes a member of a cluster of testis-specific serine proteases. The orthologous mouse gene is expressed during meiosis in pachytene spermatocytes and is required for germ cell survival. This human locus is represented as a pseudogene because it contains an early stop codon that disrupts the trypsin domain, compared to the mouse ortholog. [provided by RefSeq, Jan 20... See more...

Aliases for PRSS42P Gene

Aliases for PRSS42P Gene

  • Serine Protease 42, Pseudogene 2 3 4 5
  • Testis Serine Protease 2 2 3 4
  • Serine Protease 42 2 3
  • PRSS42 3 4
  • TESSP2 3 4
  • Putative Serine Protease 42 4
  • Protease, Serine 42 2
  • EC 3.4.21.- 4

External Ids for PRSS42P Gene

Previous HGNC Symbols for PRSS42P Gene

  • PRSS42

Summaries for PRSS42P Gene

Entrez Gene Summary for PRSS42P Gene

  • This gene encodes a member of a cluster of testis-specific serine proteases. The orthologous mouse gene is expressed during meiosis in pachytene spermatocytes and is required for germ cell survival. This human locus is represented as a pseudogene because it contains an early stop codon that disrupts the trypsin domain, compared to the mouse ortholog. [provided by RefSeq, Jan 2019]

GeneCards Summary for PRSS42P Gene

PRSS42P (Serine Protease 42, Pseudogene) is a Pseudogene. An important paralog of this gene is PLG.

UniProtKB/Swiss-Prot Summary for PRSS42P Gene

  • Plays a role in spermatogenesis. Involved in germ cell survival during meiosis.

Additional gene information for PRSS42P Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRSS42P Gene

Genomics for PRSS42P Gene

GeneHancer (GH) Regulatory Elements for PRSS42P Gene

Promoters and enhancers for PRSS42P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J046844 Promoter/Enhancer 1.8 EPDnew ENCODE CraniofacialAtlas dbSUPER 750.4 -11.8 -11786 2.6 CTCF L3MBTL2 RAD21 NKRF POLR2A ZFX SP1 ZSCAN21 ZNF687 GMEB1 lnc-PRSS42-1 PRSS42P PRSS45P PRSS50 ALS2CL PTH1R MYL3 PRSS44P NRADDP LRRC2
GH03J046834 Promoter 0.3 EPDnew 750.6 -0.1 -138 0.1 PRSS42P ALS2CL lnc-PRSS42-1
GH03J046661 Enhancer 1 Ensembl ENCODE CraniofacialAtlas 4.4 +172.3 172294 5.6 CTCF RAD21 SP1 SP7 ZIC2 PKNOX1 REST PATZ1 POLR2A ZSCAN5C ENSG00000286570 lnc-ALS2CL-1 ALS2CL PRSS45P PTH1R MYL3 LRRC2 PRSS42P lnc-PRSS50-2
GH03J046656 Enhancer 0.4 Ensembl 4.4 +177.0 176994 1.4 ZIC2 NRF1 GLIS1 TMIE ALS2CL PRSS45P PRSS50 PTH1R MYL3 TDGF1 LRRC2 PRSS42P ENSG00000286570
GH03J046646 Enhancer 0.3 Ensembl ENCODE 4.4 +187.2 187180 1.1 LRRC2 ALS2CL PRSS42P ENSG00000251967 lnc-ALS2CL-1 ENSG00000286570 lnc-TDGF1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRSS42P on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRSS42P Gene

Genomic Locations for PRSS42P Gene
chr3:46,829,542-46,834,095
(GRCh38/hg38)
Size:
4,554 bases
Orientation:
Minus strand
chr3:46,871,032-46,875,585
(GRCh37/hg19)
Size:
4,554 bases
Orientation:
Minus strand

Genomic View for PRSS42P Gene

Genes around PRSS42P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS42P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS42P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS42P Gene

Proteins for PRSS42P Gene

  • Protein details for PRSS42P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5A4-PRS42_HUMAN
    Recommended name:
    Putative serine protease 42
    Protein Accession:
    Q7Z5A4

    Protein attributes for PRSS42P Gene

    Size:
    293 amino acids
    Molecular mass:
    32006 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS42P Gene

Post-translational modifications for PRSS42P Gene

  • Glycosylation at Asn141, Asn177, and Asn276
  • Modification sites at PhosphoSitePlus

Other Protein References for PRSS42P Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for PRSS42P Gene

Domains & Families for PRSS42P Gene

Gene Families for PRSS42P Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRSS42P Gene

GenScript: Design optimal peptide antigens:
  • Testis serine protease 2 (PRS42_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z5A4

UniProtKB/Swiss-Prot:

PRS42_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS42P: view

Function for PRSS42P Gene

Molecular function for PRSS42P Gene

UniProtKB/Swiss-Prot Function:
Plays a role in spermatogenesis. Involved in germ cell survival during meiosis.

Enzyme Numbers (IUBMB) for PRSS42P Gene

Phenotypes From GWAS Catalog for PRSS42P Gene

Gene Ontology (GO) - Molecular Function for PRSS42P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IBA 21873635
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS42P: view
genes like me logo Genes that share phenotypes with PRSS42P: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS42P

CRISPR Products

miRNA for PRSS42P Gene

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRSS42P Gene

Localization for PRSS42P Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS42P Gene

Cytoplasm. Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS42P gene
Compartment Confidence
extracellular 4
plasma membrane 3
mitochondrion 1
cytosol 1
peroxisome 0
nucleus 0

Gene Ontology (GO) - Cellular Components for PRSS42P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with PRSS42P: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS42P Gene

Pathways & Interactions for PRSS42P Gene

PathCards logo

SuperPathways for PRSS42P Gene

No Data Available

Interacting Proteins for PRSS42P Gene

Gene Ontology (GO) - Biological Process for PRSS42P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA 21873635
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with PRSS42P: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS42P Gene

Drugs & Compounds for PRSS42P Gene

No Compound Related Data Available

Transcripts for PRSS42P Gene

mRNA/cDNA for PRSS42P Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS42P Gene

No ASD Table

Relevant External Links for PRSS42P Gene

GeneLoc Exon Structure for
PRSS42P
ECgene alternative splicing isoforms for
PRSS42P

Expression for PRSS42P Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PRSS42P Gene:

PRSS42P

SOURCE GeneReport for Unigene cluster for PRSS42P Gene:

Hs.585127
genes like me logo Genes that share expression patterns with PRSS42P: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS42P Gene

Orthologs for PRSS42P Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS42P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS42 33 32
  • 98.98 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS42 33 32
  • 72.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRSS42 33 32
  • 68.89 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prss42 17 33 32
  • 68.4 (n)
rat
(Rattus norvegicus)
Mammalia Prss42 32
  • 67.69 (n)
oppossum
(Monodelphis domestica)
Mammalia PRSS42 33
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 32 (a)
ManyToMany
-- 33
  • 31 (a)
ManyToMany
Species where no ortholog for PRSS42P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS42P Gene

ENSEMBL:
Gene Tree for PRSS42P (if available)
TreeFam:
Gene Tree for PRSS42P (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRSS42P: view image

Paralogs for PRSS42P Gene

genes like me logo Genes that share paralogs with PRSS42P: view

Variants for PRSS42P Gene

Sequence variations from dbSNP and Humsavar for PRSS42P Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000010674 -- 46,834,116(-) C/G/T upstream_transcript_variant
rs1000083232 -- 46,835,785(-) A/C upstream_transcript_variant
rs1000146130 -- 46,833,826(-) CCC/CC genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000929966 -- 46,835,445(-) G/A upstream_transcript_variant
rs1002121723 -- 46,830,093(-) C/T non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS42P Gene

Variant ID Type Subtype PubMed ID
dgv102e203 CNV loss 21179565
dgv4732n100 CNV loss 25217958
dgv8308n54 CNV loss 21841781
esv2759147 CNV loss 17122850
nsv1012097 CNV gain 25217958
nsv428417 CNV loss 18775914
nsv508915 CNV insertion 20534489
nsv590204 CNV loss 21841781
nsv967012 CNV duplication 23825009

Variation tolerance for PRSS42P Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS42P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS42P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS42P Gene

Disorders for PRSS42P Gene

No disorders were found for PRSS42P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for PRSS42P Gene

Publications for PRSS42P Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 4 56
  2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 56
  3. Three testis-specific paralogous serine proteases play different roles in murine spermatogenesis and are involved in germ cell survival during meiosis. (PMID: 23536369) Yoneda R … Kimura AP (Biology of reproduction 2013) 3 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 56

Products for PRSS42P Gene

Sources for PRSS42P Gene