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Aliases for PRSS42 Gene

Aliases for PRSS42 Gene

  • Protease, Serine 42 2 3 5
  • Testis Serine Protease 2 2 3 4
  • TESSP2 3 4
  • Serine Protease 42 3
  • EC 3.4.21.- 4

External Ids for PRSS42 Gene

Previous GeneCards Identifiers for PRSS42 Gene

  • GC03M046847

Summaries for PRSS42 Gene

Entrez Gene Summary for PRSS42 Gene

  • This gene encodes a member of a family of testis-specific serine proteases that also includes PRSS41, PRSS43, and PRSS44. The orthologous mouse gene is expressed during meiosis in pachytene spermatocytes and is required for germ cell survival. [provided by RefSeq, Jul 2017]

GeneCards Summary for PRSS42 Gene

PRSS42 (Protease, Serine 42) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS21.

Additional gene information for PRSS42 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS42 Gene

Genomics for PRSS42 Gene

GeneHancer (GH) Regulatory Elements for PRSS42 Gene

Promoters and enhancers for PRSS42 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I046663 Enhancer 0.4 ENCODE 4.4 +172.4 172366 0.8 GLIS1 ZBTB17 PRSS42 ENSG00000251967 ALS2CL
GH03I046646 Enhancer 0.3 ENCODE 4.4 +187.2 187180 1.1 REST LRRC2 ALS2CL PRSS42 GC03P046650 GC03P046626
GH03I046829 Enhancer 0.7 ENCODE 0.8 +4.0 3998 1 SMARCA5 PKNOX1 BACH1 TRIM22 DPF2 ZIC2 KLF5 RFX5 TARDBP IKZF1 GC03M046828 GC03M046829 PRSS45 PRSS46P PRSS42
GH03I046844 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.4 -11.8 -11786 2.6 SIN3A GLIS2 ZNF143 RUNX3 ZNF263 SP3 REST ZNF518A ZNF610 GMEB1 PRSS45 ALS2CL PTH1R MYL3 PRSS44 PRSS50 LRRC2 PRSS42
GH03I046848 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 -15.1 -15145 1.7 CTCF PKNOX1 ZBTB6 ZNF792 MAX PYGO2 RAD21 NR2F2 ZKSCAN8 ZNF143 PRSS45 ALS2CL PTH1R MYL3 PRSS44 PRSS46P PRSS42
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRSS42 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRSS42 Gene

Genomic Locations for PRSS42 Gene
4,554 bases
Minus strand

Genomic View for PRSS42 Gene

Genes around PRSS42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS42 Gene

Proteins for PRSS42 Gene

  • Protein details for PRSS42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease 42
    Protein Accession:

    Protein attributes for PRSS42 Gene

    293 amino acids
    Molecular mass:
    32006 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS42 Gene

Post-translational modifications for PRSS42 Gene

  • Glycosylation at Asn141, Asn177, and Asn276
  • Modification sites at PhosphoSitePlus

Other Protein References for PRSS42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS42 Gene

Domains & Families for PRSS42 Gene

Gene Families for PRSS42 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRSS42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS42: view

Function for PRSS42 Gene

Enzyme Numbers (IUBMB) for PRSS42 Gene

Phenotypes From GWAS Catalog for PRSS42 Gene

Gene Ontology (GO) - Molecular Function for PRSS42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS42: view
genes like me logo Genes that share phenotypes with PRSS42: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS42

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRSS42 Gene

Localization for PRSS42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS42 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS42 gene
Compartment Confidence
extracellular 4
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PRSS42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PRSS42: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS42 Gene

Pathways & Interactions for PRSS42 Gene

SuperPathways for PRSS42 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRSS42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS42: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS42 Gene

Drugs & Compounds for PRSS42 Gene

No Compound Related Data Available

Transcripts for PRSS42 Gene

mRNA/cDNA for PRSS42 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS42 Gene

Protease, serine, 42:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS42 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: -
SP2: - - -

Relevant External Links for PRSS42 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS42 Gene

This gene is overexpressed in Heart - Left Ventricle (x24.7) and Muscle - Skeletal (x8.3).

NURSA nuclear receptor signaling pathways regulating expression of PRSS42 Gene:


SOURCE GeneReport for Unigene cluster for PRSS42 Gene:

genes like me logo Genes that share expression patterns with PRSS42: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS42 Gene

Orthologs for PRSS42 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS42 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRSS42 33 34
  • 98.98 (n)
(Canis familiaris)
Mammalia PRSS42 33 34
  • 72.57 (n)
(Bos Taurus)
Mammalia PRSS42 33 34
  • 68.89 (n)
(Mus musculus)
Mammalia Prss42 33 16 34
  • 68.4 (n)
(Rattus norvegicus)
Mammalia Prss42 33
  • 67.69 (n)
(Monodelphis domestica)
Mammalia PRSS42 34
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
-- 34
  • 31 (a)
Species where no ortholog for PRSS42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS42 Gene

Gene Tree for PRSS42 (if available)
Gene Tree for PRSS42 (if available)

Paralogs for PRSS42 Gene

Variants for PRSS42 Gene

Sequence variations from dbSNP and Humsavar for PRSS42 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000010674 -- 46,834,116(-) C/G/T upstream_transcript_variant
rs1000083232 -- 46,835,785(-) A/C upstream_transcript_variant
rs1000146130 -- 46,833,826(-) CCC/CC intron_variant
rs1000929966 -- 46,835,445(-) G/A upstream_transcript_variant
rs1002121723 -- 46,830,093(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS42 Gene

Variant ID Type Subtype PubMed ID
dgv102e203 CNV loss 21179565
dgv4732n100 CNV loss 25217958
dgv8308n54 CNV loss 21841781
esv2759147 CNV loss 17122850
nsv1012097 CNV gain 25217958
nsv428417 CNV loss 18775914
nsv508915 CNV insertion 20534489
nsv590204 CNV loss 21841781
nsv967012 CNV duplication 23825009

Variation tolerance for PRSS42 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS42 Gene

Disorders for PRSS42 Gene

Additional Disease Information for PRSS42

No disorders were found for PRSS42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS42 Gene

Publications for PRSS42 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 4 58
  2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  3. Three testis-specific paralogous serine proteases play different roles in murine spermatogenesis and are involved in germ cell survival during meiosis. (PMID: 23536369) Yoneda R … Kimura AP (Biology of reproduction 2013) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization. (PMID: 8681137) Lanfranchi G … Valle G (Genome research 1996) 3 58

Products for PRSS42 Gene

Sources for PRSS42 Gene

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