PRSS41 Gene (Protein Coding)

Serine Protease 41

GC16P002798
GIFtS:
26
See more...

Aliases for PRSS41 Gene

Aliases for PRSS41 Gene

  • Serine Protease 41 2 3 4 5
  • TESSP1 2 3 4
  • Testis Serine Protease 1 2 4
  • Protease, Serine 41 2 3
  • Testis-Specific Serine Protease 1 3
  • Putative Serine Protease 41 3
  • EC 3.4.21.- 4
  • TESSP-1 4
  • PRSS41 5

External Ids for PRSS41 Gene

Previous GeneCards Identifiers for PRSS41 Gene

  • GC16P002851
  • GC16P002852
  • GC16P002815
  • GC16P002853
  • GC16P002854
  • GC16P002855
  • GC16P002856
  • GC16P002857

Summaries for PRSS41 Gene

GeneCards Summary for PRSS41 Gene

PRSS41 (Serine Protease 41) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS21.

Additional gene information for PRSS41 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRSS41 Gene

Genomics for PRSS41 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PRSS41 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRSS41 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRSS41

Genomic Locations for PRSS41 Gene

Genomic Locations for PRSS41 Gene
chr16:2,798,470-2,805,304
(GRCh38/hg38)
Size:
6,835 bases
Orientation:
Plus strand
chr16:2,848,486-2,855,148
(GRCh37/hg19)
Size:
6,663 bases
Orientation:
Plus strand

Genomic View for PRSS41 Gene

Genes around PRSS41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS41 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PRSS41 Gene

Proteins for PRSS41 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PRSS41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTY9-PRS41_HUMAN
    Recommended name:
    Serine protease 41
    Protein Accession:
    Q7RTY9

    Protein attributes for PRSS41 Gene

    Size:
    318 amino acids
    Molecular mass:
    35078 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS41 Gene

Protein Expression for PRSS41 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PRSS41 Gene

Other Protein References for PRSS41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRSS41 Gene

Domains & Families for PRSS41 Gene

Gene Families for PRSS41 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PRSS41 Gene

InterPro:
Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
ProtoNet:

Suggested Antigen Peptide Sequences for PRSS41 Gene

GenScript: Design optimal peptide antigens:
  • Testis serine protease 1 (PRS41_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7RTY9

UniProtKB/Swiss-Prot:

PRS41_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS41: view

Function for PRSS41 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Enzyme Numbers (IUBMB) for PRSS41 Gene

Phenotypes From GWAS Catalog for PRSS41 Gene

Gene Ontology (GO) - Molecular Function for PRSS41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0017080 sodium channel regulator activity IBA 21873635
genes like me logo Genes that share ontologies with PRSS41: view
genes like me logo Genes that share phenotypes with PRSS41: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS41

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS41

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS41 Gene

Localization for PRSS41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS41 Gene

Cell membrane. Lipid-anchor, GPI-anchor. Note=Localized in the plasma membrane of spermatogonia. Localized in intracellular compartment in spermatocytes, probably in the Golgi apparatus (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for PRSS41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0043229 intracellular organelle ISS --
genes like me logo Genes that share ontologies with PRSS41: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for PRSS41 Gene

Pathways & Interactions for PRSS41 Gene

genes like me logo Genes that share pathways with PRSS41: view

Interacting Proteins for PRSS41 Gene

Gene Ontology (GO) - Biological Process for PRSS41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS41: view

No data available for SIGNOR curated interactions for PRSS41 Gene

Drugs & Compounds for PRSS41 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for PRSS41 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PRSS41 Gene

2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS41

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS41 Gene

No ASD Table

Relevant External Links for PRSS41 Gene

GeneLoc Exon Structure for
PRSS41

Expression for PRSS41 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRSS41 Gene

mRNA expression in normal human tissues for PRSS41 Gene
mRNA expression by GTEx for PRSS41 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS41 Gene

This gene is overexpressed in Testis (x31.9) and Minor Salivary Gland (x4.4).

Protein differential expression in normal tissues from HIPED for PRSS41 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS41 Gene



Protein tissue co-expression partners for PRSS41 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRSS41

SOURCE GeneReport for Unigene cluster for PRSS41 Gene:

Hs.647401
genes like me logo Genes that share expression patterns with PRSS41: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS41 Gene

Orthologs for PRSS41 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRSS41 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PRSS41 30
  • 98.42 (n)
Cow
(Bos Taurus)
 Mammalia LOC617302 30
  • 72.18 (n)
Mouse
(Mus musculus)
 Mammalia Prss41 30 17
  • 71.33 (n)
Rat
(Rattus norvegicus)
 Mammalia Prss41 30
  • 69.47 (n)
Species where no ortholog for PRSS41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PRSS41 Gene

ENSEMBL:
Gene Tree for PRSS41 (if available)
TreeFam:
Gene Tree for PRSS41 (if available)

Paralogs for PRSS41 Gene

Variants for PRSS41 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRSS41 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs746540699 - p.Ser286Gly

Additional dbSNP identifiers (rs#s) for PRSS41 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRSS41 Gene

Variant ID Type Subtype PubMed ID
esv2760067 CNV gain+loss 17122850

Additional Variant Information for PRSS41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PRSS41 Gene

Disorders for PRSS41 Gene

Additional Disease Information for PRSS41

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for PRSS41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS41 Gene

Publications for PRSS41 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. A focal epilepsy and intellectual disability syndrome is due to a mutation in TBC1D24. (PMID: 20797691) Corbett MA … Gecz J (American journal of human genetics 2010) 4
  4. T-SP1: a novel serine protease-like protein predominantly expressed in testis. (PMID: 18844450) Neth P … Jochum M (Biological chemistry 2008) 23
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4

ExternalLinks

View latest publications for PRSS41 gene in Mastermind

Products for PRSS41 Gene

Sources for PRSS41 Gene