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Aliases for PRSS37 Gene

Aliases for PRSS37 Gene

  • Protease, Serine 37 2 3 5
  • Probable Inactive Trypsin-X2 3 4
  • TRYX2 3 4
  • Peptidase S1 Domain-Containing Protein LOC136242 3
  • Probable Inactive Serine Protease 37 3

External Ids for PRSS37 Gene

Previous GeneCards Identifiers for PRSS37 Gene

  • GC07M141183
  • GC07M141536
  • GC07M135832

Summaries for PRSS37 Gene

GeneCards Summary for PRSS37 Gene

PRSS37 (Protease, Serine 37) is a Protein Coding gene. Diseases associated with PRSS37 include Male Infertility. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS58.

UniProtKB/Swiss-Prot for PRSS37 Gene

  • Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation of the proacrosin/acrosin system (PubMed:27649891).

Additional gene information for PRSS37 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS37 Gene

Genomics for PRSS37 Gene

GeneHancer (GH) Regulatory Elements for PRSS37 Gene

Promoters and enhancers for PRSS37 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I141841 Promoter 0.5 EPDnew 550.8 +1.0 994 0.1 PRSS37 MYL6P4
GH07I141736 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 13.4 +104.2 104157 3.1 MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 WEE2-AS1 SSBP1 TAS2R6P TAS2R5 PRSS37 WEE2 KIAA1147 TAS2R4
GH07I141840 Enhancer 0.2 FANTOM5 65.3 +2.1 2107 0.1 PRSS37 PRSS58 MYL6P4
GH07I141812 Enhancer 0.2 FANTOM5 0.3 +29.6 29550 0.1 MYL6P4 TAS2R5 TAS2R4 WEE2 OR9A4 TAS2R38 PRSS37
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRSS37 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRSS37 Gene

Genomic Locations for PRSS37 Gene
6,222 bases
Minus strand

Genomic View for PRSS37 Gene

Genes around PRSS37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS37 Gene

Proteins for PRSS37 Gene

  • Protein details for PRSS37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable inactive serine protease 37
    Protein Accession:
    Secondary Accessions:
    • B2RPB5

    Protein attributes for PRSS37 Gene

    235 amino acids
    Molecular mass:
    26445 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS37 Gene

Post-translational modifications for PRSS37 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PRSS37 Gene

Domains & Families for PRSS37 Gene

Gene Families for PRSS37 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for PRSS37 Gene

Suggested Antigen Peptide Sequences for PRSS37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS37: view

Function for PRSS37 Gene

Molecular function for PRSS37 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation of the proacrosin/acrosin system (PubMed:27649891).

Gene Ontology (GO) - Molecular Function for PRSS37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with PRSS37: view
genes like me logo Genes that share phenotypes with PRSS37: view

Animal Models for PRSS37 Gene

MGI Knock Outs for PRSS37:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS37 Gene

Localization for PRSS37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS37 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS37 gene
Compartment Confidence
nucleus 5
extracellular 4
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PRSS37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IDA 27649891
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA,HDA 21630459
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with PRSS37: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS37 Gene

Pathways & Interactions for PRSS37 Gene

SuperPathways for PRSS37 Gene

No Data Available

Interacting Proteins for PRSS37 Gene

Gene Ontology (GO) - Biological Process for PRSS37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007338 single fertilization IEA --
GO:0007339 binding of sperm to zona pellucida ISS --
GO:0016477 cell migration ISS --
GO:0051604 protein maturation ISS --
genes like me logo Genes that share ontologies with PRSS37: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS37 Gene

Drugs & Compounds for PRSS37 Gene

No Compound Related Data Available

Transcripts for PRSS37 Gene

Unigene Clusters for PRSS37 Gene

Protease, serine, 37:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS37 Gene

No ASD Table

Relevant External Links for PRSS37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS37 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS37 Gene

This gene is overexpressed in Testis (x42.8).

Protein differential expression in normal tissues from HIPED for PRSS37 Gene

This gene is overexpressed in Testis (61.2) and Ovary (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRSS37 Gene

Protein tissue co-expression partners for PRSS37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRSS37 Gene:


SOURCE GeneReport for Unigene cluster for PRSS37 Gene:


mRNA Expression by UniProt/SwissProt for PRSS37 Gene:

Tissue specificity: Testis-specific (PubMed:27649891). Expressed in spermatids (at protein level) (PubMed:27649891).
genes like me logo Genes that share expression patterns with PRSS37: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS37 Gene

Orthologs for PRSS37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRSS37 33 34
  • 99 (n)
(Canis familiaris)
Mammalia PRSS37 33 34
  • 85.84 (n)
(Bos Taurus)
Mammalia PRSS37 33 34
  • 84.33 (n)
(Mus musculus)
Mammalia Prss37 33 16 34
  • 83.76 (n)
(Rattus norvegicus)
Mammalia Prss37 33
  • 83.48 (n)
(Monodelphis domestica)
Mammalia PRSS37 34
  • 57 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
Species where no ortholog for PRSS37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRSS37 Gene

Gene Tree for PRSS37 (if available)
Gene Tree for PRSS37 (if available)

Paralogs for PRSS37 Gene

Paralogs for PRSS37 Gene

(9) SIMAP similar genes for PRSS37 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PRSS37: view

Variants for PRSS37 Gene

Sequence variations from dbSNP and Humsavar for PRSS37 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs745313899 likely-benign, not specified 141,836,460(-) C/T coding_sequence_variant, missense_variant
rs1000087368 -- 141,837,773(-) C/T intron_variant
rs1000107818 -- 141,842,696(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000189128 -- 141,843,088(-) TTT/TTTT 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000291392 -- 141,848,832(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant

Variation tolerance for PRSS37 Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS37 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRSS37 Gene

Disorders for PRSS37 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRSS37 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
male infertility
  • infertility male
- elite association - COSMIC cancer census association via MalaCards


  • Note=Patients with unexplained male infertility (UMI) show a decrease in the number of sperm cells compared to fertile men (PubMed:27649891). Sperm exhibit also abnormal activation of the proacrosin/acrosin system and premature proteolysis of ADAM2 (PubMed:27649891). {ECO:0000269 PubMed:27649891}.

Additional Disease Information for PRSS37

genes like me logo Genes that share disorders with PRSS37: view

No data available for Genatlas for PRSS37 Gene

Publications for PRSS37 Gene

  1. Low levels of PRSS37 protein in sperm are associated with many cases of unexplained male infertility. (PMID: 27649891) Liu J … Wang Z (Acta biochimica et biophysica Sinica 2016) 3 4 58
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for PRSS37 Gene

Sources for PRSS37 Gene

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