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Aliases for PRSS36 Gene
Aliases for PRSS36 Gene
External Ids for PRSS36 Gene
- HGNC: 26906
- Entrez Gene: 146547
- Ensembl: ENSG00000178226
- OMIM: 610560
- UniProtKB: Q5K4E3
Previous GeneCards Identifiers for PRSS36 Gene
- GC16M031058
- GC16M031150
- GC16M028714
Summaries for PRSS36 Gene
GeneCards Summary for PRSS36 Gene
PRSS36 (Serine Protease 36) is a Protein Coding gene. Diseases associated with PRSS36 include Episodic Kinesigenic Dyskinesia 1. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS53.
UniProtKB/Swiss-Prot Summary for PRSS36 Gene
-
Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1.
Additional gene information for PRSS36 Gene
- HGNC(26906)
- Entrez Gene(146547)
- Ensembl(ENSG00000178226)
- OMIM(610560)
- UniProtKB(Q5K4E3)
- Open Targets Platform(ENSG00000178226)
- Search for PRSS36 at DataMed
- Search for PRSS36 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRSS36 Gene
Genomics for PRSS36 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PRSS36 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRSS36 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRSS36
- Top Transcription factor binding sites by QIAGEN in the PRSS36 gene promoter:
-
- FOXO1
- FOXO1a
- STAT1
- STAT1beta
- STAT3
- STAT5A
Genomic Locations for PRSS36 Gene
Genomic Locations for PRSS36 Gene
- chr16:31,138,926-31,150,083
- (GRCh38/hg38)
- Size:
- 11,158 bases
- Orientation:
- Minus strand
- chr16:31,150,246-31,161,415
- (GRCh37/hg19)
- Size:
- 11,170 bases
- Orientation:
- Minus strand
Genomic View for PRSS36 Gene
Genes around PRSS36 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by HGNC
- 16p11.2 by Entrez Gene
- 16p11.2 by Ensembl
PRSS36 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRSS36 Gene
Proteins for PRSS36 Gene
-
Protein details for PRSS36 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5K4E3-POLS2_HUMAN
- Recommended name:
- Polyserase-2
- Protein Accession:
- Q5K4E3
- A8K2P5
- B4DW80
- B7ZMK8
- E7EX56
- Q8NBY4
Protein attributes for PRSS36 Gene
- Size:
- 855 amino acids
- Molecular mass:
- 91955 Da
- Quaternary structure:
- No Data Available
Protein Expression for PRSS36 Gene
Selected DME Specific Peptides for PRSS36 Gene
- Q5K4E3:
-
- GDSGGPL
- WVLSAAHC
- WPWQVSLH
- DLALLQL
- SGGPLVC
- CQGDSGGP
- WPWQVSL
Post-translational modifications for PRSS36 Gene
- The 3 protease domains are not proteolytically cleaved.
- N-glycosylated.
-
Glycosylation at Asn92, Asn130, Asn217, Asn317, Asn369, Asn402, Asn407, Asn421, and Asn508
- NX_Q5K4E3 (NX_Q5K4E3-1)
Other Protein References for PRSS36 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PRSS36
- Novus Biologicals Antibodies for PRSS36
- Invitrogen Antibodies for PRSS36 (AFLGC-PRSS36)
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PRSS36
- Origene Custom Protein Services for PRSS36
- Novus Biologicals proteins for PRSS36
Assay Products
-
Signalway ELISA kits for PRSS36
Domains & Families for PRSS36 Gene
Gene Families for PRSS36 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted secreted proteins
Protein Domains for PRSS36 Gene
- InterPro:
- Blocks:
-
- Serine protease, trypsin family
- Chymotrypsin serine protease family (S1) signature
- ProtoNet:
Suggested Antigen Peptide Sequences for PRSS36 Gene
- GenScript: Design optimal peptide antigens:
-
- PRSS36 protein (B7ZMK8_HUMAN)
- Serine protease 36 (POLS2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q5K4E3UniProtKB/Swiss-Prot:
POLS2_HUMAN :- The first serine protease domain is catalytically active, whereas the second domain lacks the essential His residue of the catalytic triad at position 363, and the third domain lacks the essential Asp residue of the catalytic triad at position 679. The second and third domains are therefore predicted to be inactive (By similarity).
- Belongs to the peptidase S1 family.
- Domain:
-
- The first serine protease domain is catalytically active, whereas the second domain lacks the essential His residue of the catalytic triad at position 363, and the third domain lacks the essential Asp residue of the catalytic triad at position 679. The second and third domains are therefore predicted to be inactive (By similarity).
- Family:
-
- Belongs to the peptidase S1 family.
Function for PRSS36 Gene
Molecular function for PRSS36 Gene
- UniProtKB/Swiss-Prot Function:
- Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by serine proteinase inhibitor 4-(2-aminoethyl)-benzenesulfonyl fluoride, but not with EDTA or E-64.
Enzyme Numbers (IUBMB) for PRSS36 Gene
Phenotypes From GWAS Catalog for PRSS36 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004252 | serine-type endopeptidase activity | IDA | 15536082 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008236 | serine-type peptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PRSS36 Gene
- GenomeRNAi human phenotypes for PRSS36:
Animal Model Products
-
Taconic Biosciences Mouse Models for PRSS36
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PRSS36 - Select products 50% OFF >
- * PRSS36 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for PRSS36
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRSS36
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRSS36
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRSS36
- Browse OriGene Inhibitory RNA Products For PRSS36
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS36
Clone Products
- Applied Biological Materials (abm): Clones for PRSS36 - Select products 50% OFF >
- * PRSS36 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PRSS36
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRSS36
Cell Line Products
-
Horizon Cell Lines for PRSS36
No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS36 Gene
Localization for PRSS36 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRSS36 Gene
- Secreted, extracellular space, extracellular matrix. Note=Not attached to membranes.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| plasma membrane | 1 |
| peroxisome | 0 |
| endoplasmic reticulum | 0 |
| lysosome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005737 | cytoplasm | IDA | 15536082 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS36 Gene
Pathways & Interactions for PRSS36 Gene
Interacting Proteins for PRSS36 Gene
GPS-Prot Interaction Network for PRSS36
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PRSS36 Gene
Transcripts for PRSS36 Gene
mRNA/cDNA for PRSS36 Gene
- 3 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000268281 2811 nts (view in UCSC)
- ENST00000418068 2446 nts (view in UCSC)
- ENST00000561897 484 nts (view in UCSC)
- ENST00000562368 2778 nts (view in UCSC)
- ENST00000562390 545 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PRSS36 - Select products 50% OFF >
- * PRSS36 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PRSS36
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRSS36
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRSS36
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRSS36
- Browse OriGene Inhibitory RNA Products For PRSS36
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS36
Clone Products
- Applied Biological Materials (abm): Clones for PRSS36 - Select products 50% OFF >
- * PRSS36 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PRSS36
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRSS36
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for PRSS36 Gene
- GeneLoc Exon Structure for
- PRSS36
Expression for PRSS36 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
This gene is overexpressed in Pancreatic juice (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS36 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRSS36
SOURCE GeneReport for Unigene cluster for PRSS36 Gene:
Hs.256632mRNA Expression by UniProt/SwissProt for PRSS36 Gene:
Q5K4E3-POLS2_HUMAN
Tissue specificity:
Expressed in fetal kidney, skeletal muscle, liver, placenta and heart. Also expressed in tumor cell lines derived from lung and colon adenocarcinomas.
Evidence on tissue expression from TISSUES for PRSS36 Gene
- Liver(4.3)
Primer Products
-
OriGene qPCR primer pairs for PRSS36
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS36 Gene
Orthologs for PRSS36 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PRSS36 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PRSS36 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PRSS36 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Prss36 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Prss36 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PRSS36 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PRSS36 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101733979 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | BX571714.1 31 |
|
ManyToMany | |
| zgc:92313 31 |
|
ManyToMany |
- Species where no ortholog for PRSS36 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PRSS36 Gene
- ENSEMBL:
- Gene Tree for PRSS36 (if available)
- TreeFam:
- Gene Tree for PRSS36 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRSS36: view image
Paralogs for PRSS36 Gene
(50) SIMAP similar genes for PRSS36 Gene using alignment to 2 proteins:
- POLS2_HUMAN
- I3L3A6_HUMAN
- PRSS1
- F12
- CELA2B
- PRSS33
- ST14
- PRSS27
- UNQ9391
- TPSB2
- TMPRSS11D
- PRSS45
- PRSS41
- KLK4
- tryptaseC
- TMPRSS3
- PRSS21
- ELA2A
- CELA2A
- TPSAB1
- CELA3A
- PRSS8
- PRSS48
- PRSS22
- ELA2B
- DKFZp779M0222
- CTRL
- HPN
- GZMK
- DF
- CFD
- tryptaseB
- TRY8
- PRSS55
- KLK8
- DKFZp586F0824
- PRSS3
- KLK11
- ELA3A
- CTRB2
- CTRB1
- CELA1
- TPSD1
- PRSS42
- PRSS38
- PROC1
- KLK14
- CTRC
- CELA3B
- PROC
- PRSS2
- HP
Pseudogenes.org Pseudogenes for PRSS36 Gene
Variants for PRSS36 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRSS36 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 716414 | Benign: not provided | 31,149,125(-) | C/G | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.08;
60.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRSS36 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRSS36
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS36 Gene
Disorders for PRSS36 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| episodic kinesigenic dyskinesia 1 |
|
|
Search PRSS36 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PRSS36
No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS36 Gene
Publications for PRSS36 Gene
- Human polyserase-2, a novel enzyme with three tandem serine protease domains in a single polypeptide chain. (PMID: 15536082) Cal S … López-Otín C (The Journal of biological chemistry 2005) 2 3 4 23
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
- Expanding the complexity of the human degradome: polyserases and their tandem serine protease domains. (PMID: 17485402) Cal S … Lopez-Otin C (Frontiers in bioscience : a journal and virtual library 2007) 23
- Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain. (PMID: 16566820) Cal S … López-Otín C (BMC biochemistry 2006) 23
ExternalLinks
Products for PRSS36 Gene
- Custom Antibody ServicesOriGene Antibodies for PRSS36
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PRSS36
- Origene Custom Protein Services for PRSS36
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRSS36
- Browse OriGene Inhibitory RNA Products For PRSS36
- OriGene qPCR primer pairs for PRSS36
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for PRSS36
- Browse Sino Biological Recombinant Proteins
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PRSS36
- Novus Biologicals proteins for PRSS36
- Browse Antibodies
- Browse Peptides and Proteins
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- Browse ELISA Kits
- Taconic Biosciences Mouse Models for PRSS36
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PRSS36 (AFLGC-PRSS36)
- VectorBuilder Custom and pre-made DNA vectors for PRSS36 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PRSS36 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PRSS36 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PRSS36 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PRSS36
- antibodies-online: Show 9 available PRSS36 Antibodies ranked by validation data
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- antibodies-online: Search results for available PRSS36 related products ranked by validation data
- antibodies-online: Search results for available PRSS36 related products ranked by validation data
- Horizon Cell Lines for PRSS36
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRSS36
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRSS36
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PRSS36
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS36
- Signalway ELISA kits for PRSS36
Sources for PRSS36 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB