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Aliases for PRSS36 Gene

Aliases for PRSS36 Gene

  • Protease, Serine 36 2 3 5
  • Serine Protease 36 3 4
  • Polyserine Protease-2 3
  • Polyserine Protease 2 4
  • Protease, Serine, 36 2
  • EC 3.4.21.109 56
  • Polyserase 2 2
  • Polyserase-2 3
  • EC 3.4.21.- 4
  • EC 3.4.21 56

External Ids for PRSS36 Gene

Previous GeneCards Identifiers for PRSS36 Gene

  • GC16M031058
  • GC16M028714

Summaries for PRSS36 Gene

GeneCards Summary for PRSS36 Gene

PRSS36 (Protease, Serine 36) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TMPRSS9.

UniProtKB/Swiss-Prot for PRSS36 Gene

  • Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1.

Additional gene information for PRSS36 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS36 Gene

Genomics for PRSS36 Gene

GeneHancer (GH) Regulatory Elements for PRSS36 Gene

Promoters and enhancers for PRSS36 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I031148 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 +0.4 429 3 RB1 EGR1 SCRT2 FOS ATF7 ZNF398 REST ZEB2 SP1 NFIC PRSS36 ENSG00000260911 PRSS8
GH16I031178 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.7 -30.7 -30740 4.7 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 FUS SRCAP SETD1A SMG1P5 ZNF764 ENSG00000260267 PRR14 RNF40 ENSG00000260304 FBRS
GH16I031427 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 10.5 -279.3 -279315 4.5 RING1 MEIS2 USF1 MAX VEZF1 SCRT2 EZH2 ZNF639 RNF2 ZNF740 COX6A2 ENSG00000277543 ARMC5 FUS ENSG00000260740 ZNF785 C16orf58 MIR762HG ZNF720 SETD1A
GH16I031259 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 10.7 -110.2 -110184 1.5 EBF1 ELF1 ZFHX2 IKZF1 PRDM10 RUNX3 IKZF2 EGR2 SPI1 ITGAM PYDC1 PYCARD PRSS36 PRSS8 ITGAX
GH16I031252 Enhancer 1.5 FANTOM5 Ensembl ENCODE 10.9 -103.8 -103804 1.8 PKNOX1 ATF1 ARNT TCF12 ZNF766 E2F8 FOS ATF7 NCOA1 ZNF592 PYDC1 PYCARD TRIM72 PRSS36 ITGAM ITGAX ZNF646 ZNF668 STX4 KAT8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRSS36 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRSS36 gene promoter:

Genomic Locations for PRSS36 Gene

Genomic Locations for PRSS36 Gene
chr16:31,138,923-31,150,094
(GRCh38/hg38)
Size:
11,172 bases
Orientation:
Minus strand
chr16:31,150,246-31,161,415
(GRCh37/hg19)

Genomic View for PRSS36 Gene

Genes around PRSS36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS36 Gene

Proteins for PRSS36 Gene

  • Protein details for PRSS36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5K4E3-POLS2_HUMAN
    Recommended name:
    Polyserase-2
    Protein Accession:
    Q5K4E3
    Secondary Accessions:
    • A8K2P5
    • B4DW80
    • B7ZMK8
    • E7EX56
    • Q8NBY4

    Protein attributes for PRSS36 Gene

    Size:
    855 amino acids
    Molecular mass:
    91955 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRSS36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRSS36 Gene

Selected DME Specific Peptides for PRSS36 Gene

Q5K4E3:
  • GDSGGPL
  • WVLSAAHC
  • WPWQVSLH
  • DLALLQL
  • SGGPLVC
  • CQGDSGGP
  • WPWQVSL

Post-translational modifications for PRSS36 Gene

  • N-glycosylated.
  • The 3 protease domains are not proteolytically cleaved.
  • Glycosylation at isoforms=2, 392, isoforms=2, 3130, isoforms=2, 3217, isoforms=2, 3317, Asn369, isoforms=2, 3402, isoforms=2, 3407, Asn421, and Asn508

Domains & Families for PRSS36 Gene

Gene Families for PRSS36 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRSS36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5K4E3

UniProtKB/Swiss-Prot:

POLS2_HUMAN :
  • The first serine protease domain is catalytically active, whereas the second domain lacks the essential His residue of the catalytic triad at position 363, and the third domain lacks the essential Asp residue of the catalytic triad at position 679. The second and third domains are therefore predicted to be inactive (By similarity).
  • Belongs to the peptidase S1 family.
Domain:
  • The first serine protease domain is catalytically active, whereas the second domain lacks the essential His residue of the catalytic triad at position 363, and the third domain lacks the essential Asp residue of the catalytic triad at position 679. The second and third domains are therefore predicted to be inactive (By similarity).
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS36: view

Function for PRSS36 Gene

Molecular function for PRSS36 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by serine proteinase inhibitor 4-(2-aminoethyl)-benzenesulfonyl fluoride, but not with EDTA or E-64.
UniProtKB/Swiss-Prot Function:
Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1.

Enzyme Numbers (IUBMB) for PRSS36 Gene

Phenotypes From GWAS Catalog for PRSS36 Gene

Gene Ontology (GO) - Molecular Function for PRSS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IDA 15536082
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS36: view
genes like me logo Genes that share phenotypes with PRSS36: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS36 Gene

Localization for PRSS36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS36 Gene

Secreted, extracellular space, extracellular matrix. Note=Not attached to membranes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS36 gene
Compartment Confidence
extracellular 4
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PRSS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005737 cytoplasm IDA 15536082
genes like me logo Genes that share ontologies with PRSS36: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS36 Gene

Pathways & Interactions for PRSS36 Gene

SuperPathways for PRSS36 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRSS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS36: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS36 Gene

Drugs & Compounds for PRSS36 Gene

No Compound Related Data Available

Transcripts for PRSS36 Gene

Unigene Clusters for PRSS36 Gene

Protease, serine, 36:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS36 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b
SP1: - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for PRSS36 Gene

GeneLoc Exon Structure for
PRSS36
ECgene alternative splicing isoforms for
PRSS36

Expression for PRSS36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRSS36 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRSS36 Gene



Protein tissue co-expression partners for PRSS36 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRSS36 Gene:

PRSS36

SOURCE GeneReport for Unigene cluster for PRSS36 Gene:

Hs.256632

mRNA Expression by UniProt/SwissProt for PRSS36 Gene:

Q5K4E3-POLS2_HUMAN
Tissue specificity: Expressed in fetal kidney, skeletal muscle, liver, placenta and heart. Also expressed in tumor cell lines derived from lung and colon adenocarcinomas.

Evidence on tissue expression from TISSUES for PRSS36 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with PRSS36: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS36 Gene

Orthologs for PRSS36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS36 33 34
  • 98.43 (n)
dog
(Canis familiaris)
Mammalia PRSS36 33 34
  • 87.35 (n)
cow
(Bos Taurus)
Mammalia PRSS36 33 34
  • 87.16 (n)
rat
(Rattus norvegicus)
Mammalia Prss36 33
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Prss36 33 16 34
  • 83.27 (n)
oppossum
(Monodelphis domestica)
Mammalia PRSS36 34
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRSS36 34
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 21 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733979 33
  • 48.21 (n)
zebrafish
(Danio rerio)
Actinopterygii BX571714.1 34
  • 39 (a)
ManyToMany
zgc:92313 34
  • 34 (a)
ManyToMany
Species where no ortholog for PRSS36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS36 Gene

ENSEMBL:
Gene Tree for PRSS36 (if available)
TreeFam:
Gene Tree for PRSS36 (if available)

Paralogs for PRSS36 Gene

Variants for PRSS36 Gene

Sequence variations from dbSNP and Humsavar for PRSS36 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000046435 -- 31,144,093(-) G/C intron_variant
rs1000077537 -- 31,143,761(-) C/A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000197605 -- 31,145,144(-) T/G intron_variant
rs1000267707 -- 31,149,912(-) C/T 5_prime_UTR_variant, intron_variant
rs1000700085 -- 31,150,236(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS36 Gene

Variant ID Type Subtype PubMed ID
nsv457483 CNV loss 19166990
nsv571820 CNV loss 21841781

Variation tolerance for PRSS36 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS36 Gene

Disorders for PRSS36 Gene

Additional Disease Information for PRSS36

No disorders were found for PRSS36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS36 Gene

Publications for PRSS36 Gene

  1. Human polyserase-2, a novel enzyme with three tandem serine protease domains in a single polypeptide chain. (PMID: 15536082) Cal S … López-Otín C (The Journal of biological chemistry 2005) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Expanding the complexity of the human degradome: polyserases and their tandem serine protease domains. (PMID: 17485402) Cal S … Lopez-Otin C (Frontiers in bioscience : a journal and virtual library 2007) 22 58
  4. Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain. (PMID: 16566820) Cal S … López-Otín C (BMC biochemistry 2006) 22 58
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 3 58

Products for PRSS36 Gene

Sources for PRSS36 Gene

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