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Aliases for PRSS35 Gene

Aliases for PRSS35 Gene

  • Protease, Serine 35 2 3 5
  • C6orf158 3 4
  • Chromosome 6 Open Reading Frame 158 2
  • Inactive Serine Protease 35 3
  • EC 56
  • DJ223E3.1 3
  • EC 3.4.21 56

External Ids for PRSS35 Gene

Previous HGNC Symbols for PRSS35 Gene

  • C6orf158

Previous GeneCards Identifiers for PRSS35 Gene

  • GC06P084278

Summaries for PRSS35 Gene

GeneCards Summary for PRSS35 Gene

PRSS35 (Protease, Serine 35) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS23.

Additional gene information for PRSS35 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS35 Gene

Genomics for PRSS35 Gene

GeneHancer (GH) Regulatory Elements for PRSS35 Gene

Promoters and enhancers for PRSS35 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I083511 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 568.7 -0.2 -184 1.8 RB1 KLF17 MZF1 SIN3A ZNF2 RAD21 ZNF335 GLIS2 ZNF213 ZNF143 PRSS35 ME1
GH06I083429 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 18.1 -80.9 -80911 3.9 HDGF PKNOX1 ARNT SIN3A ZNF2 POLR2B CBX5 FOS SP3 SMARCB1 ME1 PRSS35 CEP162 ENSG00000219951
GH06I083463 Enhancer 1.1 FANTOM5 Ensembl ENCODE 26.5 -47.9 -47890 2.3 MEIS2 PKNOX1 TEAD4 MZF1 FEZF1 SCRT2 ZNF350 SCRT1 CBFA2T3 CEBPB PRSS35 CEP162 ME1 CYB5R4
GH06I083215 Enhancer 1 Ensembl ENCODE 16.9 -296.8 -296767 1 RB1 INSM2 ARID4B ZNF2 RAD21 YY1 ZNF143 RCOR1 BCLAF1 RUNX3 PRSS35 PGM3 RWDD2A UBE3D DOPEY1 GC06M083097 GC06P083243 ME1
GH06I083434 Enhancer 0.9 Ensembl ENCODE 11 -77.9 -77874 0.8 FOXA2 SMAD1 NFIB MZF1 CTBP1 ZNF547 PRDM10 IKZF2 RUNX3 RXRA PRSS35 ME1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRSS35 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRSS35 gene promoter:

Genomic Locations for PRSS35 Gene

Genomic Locations for PRSS35 Gene
13,230 bases
Plus strand

Genomic View for PRSS35 Gene

Genes around PRSS35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS35 Gene

Proteins for PRSS35 Gene

  • Protein details for PRSS35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive serine protease 35
    Protein Accession:
    Secondary Accessions:
    • A8K7B3
    • Q9BQP6

    Protein attributes for PRSS35 Gene

    413 amino acids
    Molecular mass:
    47098 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS35 Gene

Selected DME Specific Peptides for PRSS35 Gene


Post-translational modifications for PRSS35 Gene

  • Glycosylation at isoforms=90
  • Modification sites at PhosphoSitePlus

Other Protein References for PRSS35 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PRSS35 Gene

Gene Families for PRSS35 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRSS35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS35: view

Function for PRSS35 Gene

Enzyme Numbers (IUBMB) for PRSS35 Gene

Phenotypes From GWAS Catalog for PRSS35 Gene

genes like me logo Genes that share phenotypes with PRSS35: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS35

Inhibitory RNA Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS35 Gene

Localization for PRSS35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS35 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS35 gene
Compartment Confidence
extracellular 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PRSS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with PRSS35: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS35 Gene

Pathways & Interactions for PRSS35 Gene

SuperPathways for PRSS35 Gene

No Data Available

Interacting Proteins for PRSS35 Gene

Gene Ontology (GO) - Biological Process for PRSS35 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRSS35 Gene

Drugs & Compounds for PRSS35 Gene

No Compound Related Data Available

Transcripts for PRSS35 Gene

mRNA/cDNA for PRSS35 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS35 Gene

Protease, serine, 35:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS35 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for PRSS35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS35 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.7), Brain - Nucleus accumbens (basal ganglia) (x5.1), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for PRSS35 Gene

This gene is overexpressed in Vitreous humor (39.2) and Retina (29.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRSS35 Gene

Protein tissue co-expression partners for PRSS35 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRSS35 Gene:


SOURCE GeneReport for Unigene cluster for PRSS35 Gene:


Evidence on tissue expression from TISSUES for PRSS35 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with PRSS35: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS35 Gene

Orthologs for PRSS35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRSS35 33 34
  • 99.27 (n)
(Canis familiaris)
Mammalia PRSS35 33 34
  • 88.92 (n)
(Bos Taurus)
Mammalia PRSS35 33 34
  • 82.85 (n)
(Rattus norvegicus)
Mammalia Prss35 33
  • 78.65 (n)
(Mus musculus)
Mammalia Prss35 33 16 34
  • 78.32 (n)
(Ornithorhynchus anatinus)
Mammalia PRSS35 34
  • 72 (a)
(Gallus gallus)
Aves PRSS35 33 34
  • 70.39 (n)
(Anolis carolinensis)
Reptilia PRSS35 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prss35 33
  • 62.47 (n)
(Danio rerio)
Actinopterygii prss35 33 34
  • 60.23 (n)
PRSS35 (2 of 2) 34
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
Species where no ortholog for PRSS35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS35 Gene

Gene Tree for PRSS35 (if available)
Gene Tree for PRSS35 (if available)

Paralogs for PRSS35 Gene

Paralogs for PRSS35 Gene

(1) SIMAP similar genes for PRSS35 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRSS35: view

Variants for PRSS35 Gene

Sequence variations from dbSNP and Humsavar for PRSS35 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000011463 -- 83,511,255(+) A/G upstream_transcript_variant
rs1000294285 -- 83,524,272(+) T/C coding_sequence_variant, synonymous_variant
rs1000501772 -- 83,511,999(+) T/C upstream_transcript_variant
rs1000870455 -- 83,522,504(+) C/A intron_variant
rs1000914063 -- 83,511,760(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS35 Gene

Variant ID Type Subtype PubMed ID
esv3540072 CNV deletion 23714750
esv3571277 CNV loss 25503493
esv996120 CNV deletion 20482838
nsv1068710 OTHER inversion 25765185
nsv1153488 OTHER inversion 26484159
nsv518229 CNV loss 19592680

Variation tolerance for PRSS35 Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS35 Gene

Disorders for PRSS35 Gene

Additional Disease Information for PRSS35

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PRSS35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS35 Gene

Publications for PRSS35 Gene

  1. Novel cleft susceptibility genes in chromosome 6q. (PMID: 20511563) Letra A … Vieira AR (Journal of dental research 2010) 3 44 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies. (PMID: 16870946) Miyakoshi K … Hennebold JD (Biology of reproduction 2006) 3 22 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58

Products for PRSS35 Gene

Sources for PRSS35 Gene

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