Aliases for PRSS35 Gene

Aliases for PRSS35 Gene

  • Serine Protease 35 2 3 5
  • Inactive Serine Protease 35 3 4
  • Protease, Serine 35 2 3
  • C6orf158 3 4
  • Chromosome 6 Open Reading Frame 158 2
  • EC 3.4.21.4 52
  • DJ223E3.1 3
  • EC 3.4.21 52

External Ids for PRSS35 Gene

Previous HGNC Symbols for PRSS35 Gene

  • C6orf158

Previous GeneCards Identifiers for PRSS35 Gene

  • GC06P084278

Summaries for PRSS35 Gene

GeneCards Summary for PRSS35 Gene

PRSS35 (Serine Protease 35) is a Protein Coding gene. Diseases associated with PRSS35 include Pontocerebellar Hypoplasia, Type 6. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS23.

Additional gene information for PRSS35 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRSS35 Gene

Genomics for PRSS35 Gene

GeneHancer (GH) Regulatory Elements for PRSS35 Gene

Promoters and enhancers for PRSS35 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J083511 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 518.6 +0.1 109 2.4 HNRNPK CTCF ZIC2 ZNF423 ZBTB26 TRIM28 REST CTBP1 MYC SMC3 PRSS35 piR-39341-338
GH06J083429 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 18.1 -81.2 -81212 4.5 ZNF217 ZSCAN5C PHF8 FOS ZFX ZNF639 ZNF10 ZIC2 ZBTB10 CLOCK ME1 PRSS35 ENSG00000219951
GH06J083463 Enhancer 1.1 FANTOM5 Ensembl ENCODE 26.5 -45.5 -45475 7.2 TRIM28 OSR2 BCL11A ZNF316 PBX2 MAFF ZNF263 FOS SPI1 ZNF335 PRSS35 ME1 CEP162 CYB5R4 HSALNG0051610 piR-38580-293
GH06J083215 Enhancer 0.9 Ensembl ENCODE 16.9 -296.8 -296844 1.2 CTCF TEAD4 REST RAD21 TRIM22 TEAD1 SMC3 MXI1 ZNF341 ZNF524 PRSS35 PGM3 RWDD2A DOP1A UBE3D HE855980 piR-52294-121 ME1
GH06J083474 Enhancer 0.6 Ensembl 26.7 -37.9 -37875 0.4 FOXA2 ZBTB33 SCRT1 RAD21 RXRA MAX HNF4A FOXA1 L3MBTL2 YY1 piR-33614-244 piR-38580-293 PRSS35 HSALNG0051610
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRSS35 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRSS35

Top Transcription factor binding sites by QIAGEN in the PRSS35 gene promoter:
  • AREB6
  • Cdc5
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • TBP

Genomic Locations for PRSS35 Gene

Genomic Locations for PRSS35 Gene
chr6:83,512,475-83,525,704
(GRCh38/hg38)
Size:
13,230 bases
Orientation:
Plus strand
chr6:84,222,194-84,235,423
(GRCh37/hg19)
Size:
13,230 bases
Orientation:
Plus strand

Genomic View for PRSS35 Gene

Genes around PRSS35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS35 Gene

Proteins for PRSS35 Gene

  • Protein details for PRSS35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3Z0-PRS35_HUMAN
    Recommended name:
    Inactive serine protease 35
    Protein Accession:
    Q8N3Z0
    Secondary Accessions:
    • A8K7B3
    • Q9BQP6

    Protein attributes for PRSS35 Gene

    Size:
    413 amino acids
    Molecular mass:
    47098 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS35 Gene

Selected DME Specific Peptides for PRSS35 Gene

Q8N3Z0:
  • VLTAAHC
  • DYDYALLEL

Post-translational modifications for PRSS35 Gene

  • Glycosylation at Asn90
  • Modification sites at PhosphoSitePlus

Other Protein References for PRSS35 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PRSS35 Gene

Gene Families for PRSS35 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for PRSS35 Gene

Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRSS35 Gene

GenScript: Design optimal peptide antigens:
  • Inactive serine protease 35 (PRS35_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N3Z0

UniProtKB/Swiss-Prot:

PRS35_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS35: view

Function for PRSS35 Gene

Enzyme Numbers (IUBMB) for PRSS35 Gene

Phenotypes From GWAS Catalog for PRSS35 Gene

Gene Ontology (GO) - Molecular Function for PRSS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27499296
genes like me logo Genes that share ontologies with PRSS35: view
genes like me logo Genes that share phenotypes with PRSS35: view

Animal Models for PRSS35 Gene

MGI Knock Outs for PRSS35:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS35

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS35

Clone Products

No data available for Molecular function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS35 Gene

Localization for PRSS35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS35 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS35 gene
Compartment Confidence
extracellular 3
plasma membrane 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PRSS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PRSS35: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS35 Gene

Pathways & Interactions for PRSS35 Gene

PathCards logo

SuperPathways for PRSS35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRSS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS35: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS35 Gene

Drugs & Compounds for PRSS35 Gene

No Compound Related Data Available

Transcripts for PRSS35 Gene

mRNA/cDNA for PRSS35 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS35

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS35 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for PRSS35 Gene

GeneLoc Exon Structure for
PRSS35

Expression for PRSS35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRSS35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS35 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.7), Brain - Nucleus accumbens (basal ganglia) (x5.1), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for PRSS35 Gene

This gene is overexpressed in Vitreous humor (39.2) and Retina (29.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS35 Gene



Protein tissue co-expression partners for PRSS35 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRSS35

SOURCE GeneReport for Unigene cluster for PRSS35 Gene:

Hs.98381

Evidence on tissue expression from TISSUES for PRSS35 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with PRSS35: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS35 Gene

Orthologs for PRSS35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS35 31 30
  • 99.27 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS35 31 30
  • 88.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRSS35 31 30
  • 82.85 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prss35 30
  • 78.65 (n)
mouse
(Mus musculus)
Mammalia Prss35 17 31 30
  • 78.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRSS35 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRSS35 31 30
  • 70.39 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRSS35 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prss35 30
  • 62.47 (n)
zebrafish
(Danio rerio)
Actinopterygii prss35 31 30
  • 60.23 (n)
OneToMany
PRSS35 (2 of 2) 31
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 38 (a)
OneToMany
Species where no ortholog for PRSS35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS35 Gene

ENSEMBL:
Gene Tree for PRSS35 (if available)
TreeFam:
Gene Tree for PRSS35 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRSS35: view image

Paralogs for PRSS35 Gene

Paralogs for PRSS35 Gene

(1) SIMAP similar genes for PRSS35 Gene using alignment to 1 proteins:

  • PRS35_HUMAN
genes like me logo Genes that share paralogs with PRSS35: view

Variants for PRSS35 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRSS35 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs504593 - p.Arg224Gln

Additional dbSNP identifiers (rs#s) for PRSS35 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRSS35 Gene

Variant ID Type Subtype PubMed ID
esv3540072 CNV deletion 23714750
esv3571277 CNV loss 25503493
esv996120 CNV deletion 20482838
nsv1068710 OTHER inversion 25765185
nsv1153488 OTHER inversion 26484159
nsv518229 CNV loss 19592680

Variation tolerance for PRSS35 Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS35 Gene

Disorders for PRSS35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRSS35 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pontocerebellar hypoplasia, type 6
  • pch6
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PRSS35

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRSS35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS35 Gene

Publications for PRSS35 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  2. Novel cleft susceptibility genes in chromosome 6q. (PMID: 20511563) Letra A … Vieira AR (Journal of dental research 2010) 3 41 54
  3. The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies. (PMID: 16870946) Miyakoshi K … Hennebold JD (Biology of reproduction 2006) 3 23 54
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 54

Products for PRSS35 Gene

Sources for PRSS35 Gene