Aliases for PRSS3 Gene
External Ids for PRSS3 Gene
Previous HGNC Symbols for PRSS3 Gene
Previous GeneCards Identifiers for PRSS3 Gene
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
GeneCards Summary for PRSS3 Gene
PRSS3 (Serine Protease 3) is a Protein Coding gene. Diseases associated with PRSS3 include Thyroiditis and Hashimoto Thyroiditis. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Cobalamin (Cbl, vitamin B12) transport and metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and serine-type peptidase activity. An important paralog of this gene is PRSS2.
UniProtKB/Swiss-Prot Summary for PRSS3 Gene
Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors.