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Aliases for PRSS3 Gene

Aliases for PRSS3 Gene

  • Serine Protease 3 2 3 4 5
  • Protease, Serine, 4 (Trypsin 4, Brain) 2 3
  • Protease, Serine 3 2 3
  • Brain Trypsinogen 3 4
  • Mesotrypsinogen 3 4
  • Trypsin III 3 4
  • Mesotrypsin 2 3
  • Trypsin IV 3 4
  • PRSS4 3 4
  • TRY3 3 4
  • TRY4 3 4
  • Protease, Serine, 3 (Mesotrypsin) 2
  • Pancreatic Trypsinogen III 3
  • Serine Protease 4 4
  • Trypsinogen IV 3
  • Trypsinogen 4 3
  • Trypsinogen 5 3
  • EC 3.4.21.4 4
  • Trypsin-3 3
  • MTG 3
  • T9 3

External Ids for PRSS3 Gene

Previous HGNC Symbols for PRSS3 Gene

  • PRSS4

Previous GeneCards Identifiers for PRSS3 Gene

  • GC09P034062
  • GC09P033919
  • GC09P033740
  • GC09P033708

Summaries for PRSS3 Gene

Entrez Gene Summary for PRSS3 Gene

  • This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for PRSS3 Gene

PRSS3 (Serine Protease 3) is a Protein Coding gene. Diseases associated with PRSS3 include Thyroiditis and Pancreatitis. Among its related pathways are Defensins and Metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and serine-type peptidase activity. An important paralog of this gene is PRSS2.

UniProtKB/Swiss-Prot for PRSS3 Gene

  • Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.

Additional gene information for PRSS3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS3 Gene

Genomics for PRSS3 Gene

GeneHancer (GH) Regulatory Elements for PRSS3 Gene

Promoters and enhancers for PRSS3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J033749 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 657.2 +1.5 1455 4.2 SOX13 TFAP4 FOXA2 SAP130 ARID4B MAX CEBPG YY1 EGR1 HNF4G PRSS3 ENSG00000260947 TRBV26OR9-2 RNU4ATAC11P UBE2R2 UBAP2 LINC01251 ENSG00000227301 NOL6 TRBV29OR9-2
GH09J033795 Promoter/Enhancer 1.1 EPDnew dbSUPER 650.2 +45.1 45076 0.1 HDAC1 PKNOX1 CEBPB CEBPG ZEB2 EP300 ATF4 CTBP1 IKZF1 TRIM24 PRSS3 GC09P034317 UBE2R2 UBE2R2-AS1
GH09J033748 Enhancer 0.5 ENCODE 657.6 -1.4 -1435 0.8 ZNF316 NFATC3 ASH1L ZFP91 EMSY MAFK PRSS3 TRBV26OR9-2 LINC01251 ENSG00000260947
GH09J033813 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.4 +66.2 66246 6.9 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 UBE2R2 B4GALT1 UBAP1 ENSG00000228352 PTENP1 PRSS3 ENSG00000260947 ENSG00000230074 UBAP2 DCAF12
GH09J033613 Enhancer 0.2 FANTOM5 73.7 -136.4 -136448 0.2 PRSS3P4 PRSS3 LINC01251 ENSG00000260947 TRBV20OR9-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRSS3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRSS3 gene promoter:
  • E47
  • Zic3
  • AML1a
  • ITF-2
  • Tal-1beta
  • Nkx5-1
  • C/EBPalpha
  • AREB6

Genomic Locations for PRSS3 Gene

Genomic Locations for PRSS3 Gene
chr9:33,750,466-33,799,231
(GRCh38/hg38)
Size:
48,766 bases
Orientation:
Plus strand
chr9:33,750,464-33,799,230
(GRCh37/hg19)
Size:
48,767 bases
Orientation:
Plus strand

Genomic View for PRSS3 Gene

Genes around PRSS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS3 Gene

Proteins for PRSS3 Gene

  • Protein details for PRSS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35030-TRY3_HUMAN
    Recommended name:
    Trypsin-3
    Protein Accession:
    P35030
    Secondary Accessions:
    • A8CED1
    • A8CED3
    • A9Z1Y4
    • E7ES07
    • F8W7P3
    • P15951
    • Q15665
    • Q5VXV0
    • Q6ISJ4
    • Q9UQV3

    Protein attributes for PRSS3 Gene

    Size:
    304 amino acids
    Molecular mass:
    32529 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRSS3 Gene

    Alternative splice isoforms for PRSS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRSS3 Gene

Post-translational modifications for PRSS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRSS3 Gene

Domains & Families for PRSS3 Gene

Gene Families for PRSS3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

P35030

UniProtKB/Swiss-Prot:

TRY3_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS3: view

Function for PRSS3 Gene

Molecular function for PRSS3 Gene

UniProtKB/Swiss-Prot Function:
Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Arg- -Xaa, Lys- -Xaa.
GENATLAS Biochemistry:
protease serine 3,trypsin 3,expressed in brain

Enzyme Numbers (IUBMB) for PRSS3 Gene

Phenotypes From GWAS Catalog for PRSS3 Gene

Gene Ontology (GO) - Molecular Function for PRSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IDA 6698368
GO:0005509 calcium ion binding IDA 6698368
GO:0005515 protein binding IPI 6698368
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS --
genes like me logo Genes that share ontologies with PRSS3: view
genes like me logo Genes that share phenotypes with PRSS3: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS3 Gene

Localization for PRSS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS3 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 2
plasma membrane 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 6698368
GO:0070062 extracellular exosome HDA --
GO:1904724 tertiary granule lumen TAS --
genes like me logo Genes that share ontologies with PRSS3: view

Pathways & Interactions for PRSS3 Gene

genes like me logo Genes that share pathways with PRSS3: view

Gene Ontology (GO) - Biological Process for PRSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS,TAS 8294000
GO:0007586 digestion IEA,TAS 6698368
GO:0009235 cobalamin metabolic process TAS --
GO:0019730 antimicrobial humoral response TAS --
GO:0031638 zymogen activation IDA 6698368
genes like me logo Genes that share ontologies with PRSS3: view

No data available for SIGNOR curated interactions for PRSS3 Gene

Drugs & Compounds for PRSS3 Gene

(14) Drugs for PRSS3 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
[3-(1,3,2-Dioxaborolan-2-Yloxy)Propyl]Guanidine Experimental Pharma Target 0
[4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]Benzamidine Experimental Pharma Target 0
1,3,2-Dioxaborolan-2-Ol Experimental Pharma Target 0
4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-Aminium Experimental Pharma Target 0

(2) Additional Compounds for PRSS3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRSS3: view

Transcripts for PRSS3 Gene

Unigene Clusters for PRSS3 Gene

Protease, serine, 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - -
SP2: -
SP3:

Relevant External Links for PRSS3 Gene

GeneLoc Exon Structure for
PRSS3
ECgene alternative splicing isoforms for
PRSS3

Expression for PRSS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS3 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS3 Gene

This gene is overexpressed in Pancreas (x45.7).

Protein differential expression in normal tissues from HIPED for PRSS3 Gene

This gene is overexpressed in Pancreatic juice (50.1) and Ovary (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS3 Gene



NURSA nuclear receptor signaling pathways regulating expression of PRSS3 Gene:

PRSS3

SOURCE GeneReport for Unigene cluster for PRSS3 Gene:

Hs.654513

mRNA Expression by UniProt/SwissProt for PRSS3 Gene:

P35030-TRY3_HUMAN
Tissue specificity: Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts.

Evidence on tissue expression from TISSUES for PRSS3 Gene

  • Pancreas(4.8)
  • Nervous system(4.5)
  • Thyroid gland(2.5)
  • Intestine(2.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with PRSS3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS3 Gene

Orthologs for PRSS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100615846 33
  • 93.66 (n)
-- 34
  • 89 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Try4 33
  • 82.93 (n)
mouse
(Mus musculus)
Mammalia Try5 16 34 33
  • 82.52 (n)
Prss1 34
  • 76 (a)
ManyToMany
Try10 34
  • 76 (a)
ManyToMany
Gm10334 34
  • 76 (a)
ManyToMany
Try4 34
  • 76 (a)
ManyToMany
Gm5771 34
  • 76 (a)
ManyToMany
Prss3 34
  • 75 (a)
ManyToMany
Prss2 34
  • 73 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 77 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PRSS2 34
  • 74 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
ManyToMany
-- 34
  • 71 (a)
ManyToMany
-- 34
  • 68 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
ManyToMany
-- 34
  • 67 (a)
ManyToMany
-- 34
  • 65 (a)
ManyToMany
-- 34
  • 64 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PRSS2 34
  • 66 (a)
ManyToMany
PRSS3 34 34
  • 65 (a)
ManyToMany
-- 34
  • 63 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 67 (a)
ManyToMany
-- 34
  • 63 (a)
ManyToMany
-- 34
  • 57 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC64344 33
zebrafish
(Danio rerio)
Actinopterygii try 34
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31954 33
  • 52.23 (n)
CG4386 35
  • 42 (a)
Try29F 35
  • 41 (a)
CG8299 35
  • 39 (a)
CG6041 35
  • 38 (a)
&lgr;Try 35
  • 37 (a)
CG5197 35
  • 37 (a)
&egr;Try 35
  • 36 (a)
CG17571 35
  • 36 (a)
CG17239 35
  • 36 (a)
&kgr;Try 35
  • 33 (a)
CG7829 35
  • 33 (a)
&eegr;Try 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4556 34
  • 44 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
CSA.4402 34
  • 43 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
Species where no ortholog for PRSS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS3 Gene

ENSEMBL:
Gene Tree for PRSS3 (if available)
TreeFam:
Gene Tree for PRSS3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRSS3: view image

Paralogs for PRSS3 Gene

Paralogs for PRSS3 Gene

genes like me logo Genes that share paralogs with PRSS3: view

Variants for PRSS3 Gene

Sequence variations from dbSNP and Humsavar for PRSS3 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000098145 -- 33,784,988(+) T/A/C genic_upstream_transcript_variant, intron_variant
rs1000339985 -- 33,792,448(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000350529 -- 33,769,745(+) CCCC/CCC genic_upstream_transcript_variant, intron_variant
rs1000531925 -- 33,763,144(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000566988 -- 33,756,465(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS3 Gene

Variant ID Type Subtype PubMed ID
dgv7518n100 CNV gain 25217958
esv24699 CNV loss 19812545
esv2738377 CNV deletion 23290073
esv2738378 CNV deletion 23290073
esv2738379 CNV deletion 23290073
esv2761525 CNV gain 21179565
nsv1125318 OTHER inversion 24896259
nsv471653 CNV gain 15918152
nsv518977 CNV gain 19592680
nsv824910 CNV loss 20364138
nsv8444 CNV loss 18304495
nsv968607 CNV duplication 23825009
nsv968608 CNV duplication 23825009

Variation tolerance for PRSS3 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.46; 77.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS3 Gene

Disorders for PRSS3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for PRSS3 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PRSS3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRSS3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRSS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS3 Gene

Publications for PRSS3 Gene

  1. Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiation. (PMID: 19924134) Nakanishi J … Hibino T (The Journal of investigative dermatology 2010) 3 4 22 58
  2. Genetic and biochemical characterization of the E32del polymorphism in human mesotrypsinogen. (PMID: 15855826) Nemoda Z … Sahin-Tóth M (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2005) 3 22 44 58
  3. Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors. (PMID: 14507909) Szmola R … Sahin-Tóth M (The Journal of biological chemistry 2003) 3 4 22 58
  4. Crystal structure reveals basis for the inhibitor resistance of human brain trypsin. (PMID: 11827488) Katona G … Szilágyi L (Journal of molecular biology 2002) 3 4 22 58
  5. Cloning of the cDNA encoding human brain trypsinogen and characterization of its product. (PMID: 8294000) Wiegand U … Müller-Hill B (Gene 1993) 2 3 4 58

Products for PRSS3 Gene

  • Boster Bio Antibodies for PRSS3
  • Boster Bio ELISA Kits for PRSS3

Sources for PRSS3 Gene

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