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Aliases for PRSS27 Gene

Aliases for PRSS27 Gene

  • Serine Protease 27 2 3 4 5
  • Pancreasin 2 3 4
  • Marapsin 2 3 4
  • Protease, Serine 27 2 3
  • MPN 3 4
  • Channel-Activating Protease 2 3
  • EC 3.4.21.43 56
  • EC 3.4.21.4 56
  • EC 3.4.21.- 4
  • EC 3.4.21 56
  • CAPH2 3

External Ids for PRSS27 Gene

Previous GeneCards Identifiers for PRSS27 Gene

  • GC16U990229
  • GC16M002704
  • GC16M002705
  • GC16M002733
  • GC16M002768

Summaries for PRSS27 Gene

Entrez Gene Summary for PRSS27 Gene

  • This gene is located within a large protease gene cluster on chromosome 16. It belongs to the group-1 subfamily of serine proteases. The encoded protein is a secreted tryptic serine protease and is expressed mainly in the pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for PRSS27 Gene

PRSS27 (Serine Protease 27) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS33.

Additional gene information for PRSS27 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS27 Gene

Genomics for PRSS27 Gene

GeneHancer (GH) Regulatory Elements for PRSS27 Gene

Promoters and enhancers for PRSS27 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J002719 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 600.7 -0.3 -283 3.1 SP1 CTCF ZFX ELF3 SIX5 NKRF POLR2A ZNF687 ZSCAN21 NCOA3 PRSS27 TIGD7 NME3 CLUAP1 ZNF213-AS1 ZNF75A ZNF174 MTCO1P28 FLYWCH1 MTND1P8
GH16J002718 Promoter 1 Ensembl 600.7 +1.7 1677 0.6 ZNF121 SP1 RXRA CEBPA ESRRA ZNF217 GABPA BCOR NFIB SIN3A PRSS27 GC16M002714 ZNF598 SRRM2 TRAF7 TBL3 ENSG00000255513 THOC6 SNORA64 ENSG00000262482
GH16J002750 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12 -32.6 -32590 4.9 ZNF652 SP1 ELF3 ZFX ZKSCAN8 MNT SIX5 ZNF148 NKRF POLR2A SRRM2 GC16P003906 SRRM2-AS1 ZNF75A ERVK13-1 ZNF263 TSC2 ZNF213-AS1 E4F1 ENSG00000261938
GH16J002774 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.2 -56.7 -56703 4.6 ZFX ZNF148 NKRF POLR2A MLLT1 ZNF121 GTF2F1 ZNF687 NFRKB AHR ELOB ENSG00000276791 GC16P003887 PIR54527 MTCO1P28 ZNF597 SRRM2 TBL3 SRRM2-AS1 PRSS27
GH16J002911 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 -191.7 -191723 2.6 SP1 ZFX ELF3 ZKSCAN8 MNT ZNF148 NKRF POLR2A MLLT1 CEBPG FLYWCH1 FLYWCH2 ZNF263 ZNF75A TSC2 E4F1 ZNF174 ZNF213-AS1 CREBBP PRSS27
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRSS27 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRSS27 gene promoter:
  • CREB
  • deltaCREB
  • NRSF form 1
  • NRSF form 2

Genomic Locations for PRSS27 Gene

Genomic Locations for PRSS27 Gene
chr16:2,712,418-2,720,578
(GRCh38/hg38)
Size:
8,161 bases
Orientation:
Minus strand
chr16:2,762,419-2,770,552
(GRCh37/hg19)
Size:
8,134 bases
Orientation:
Minus strand

Genomic View for PRSS27 Gene

Genes around PRSS27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS27 Gene

Proteins for PRSS27 Gene

  • Protein details for PRSS27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQR3-PRS27_HUMAN
    Recommended name:
    Serine protease 27
    Protein Accession:
    Q9BQR3

    Protein attributes for PRSS27 Gene

    Size:
    290 amino acids
    Molecular mass:
    31940 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS27 Gene

Selected DME Specific Peptides for PRSS27 Gene

Q9BQR3:
  • PWQVSIQ
  • VLTAAHC
  • SWGEGCA
  • GDSGGPL
  • SGGPLVC
  • FCGGSLI
  • CWVTGWG
  • CKGDSGG
  • HFCGGSL
  • WVLTAAHCFR
  • LTAAHCF
  • WVLTAAH

Post-translational modifications for PRSS27 Gene

Other Protein References for PRSS27 Gene

Domains & Families for PRSS27 Gene

Gene Families for PRSS27 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRSS27 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ31014 fis, clone HLUNG2000255, highly similar to Protease serine 27 (EC 3.4.21.-) (B3KP25_HUMAN)
  • Pancreasin (PRS27_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BQR3

UniProtKB/Swiss-Prot:

PRS27_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS27: view

Function for PRSS27 Gene

Enzyme Numbers (IUBMB) for PRSS27 Gene

Phenotypes From GWAS Catalog for PRSS27 Gene

Gene Ontology (GO) - Molecular Function for PRSS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS27: view
genes like me logo Genes that share phenotypes with PRSS27: view

Animal Models for PRSS27 Gene

MGI Knock Outs for PRSS27:
  • Prss27 Prss27<tm1.1(NCOM)Mfgc>

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS27

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PRSS27 - Now 50% OFF >
  • * PRSS27 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRSS27 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS27 Gene

Localization for PRSS27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS27 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS27 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 1
nucleus 1
lysosome 1
mitochondrion 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for PRSS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0019897 extrinsic component of plasma membrane IBA 21873635
GO:0046658 anchored component of plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with PRSS27: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS27 Gene

Pathways & Interactions for PRSS27 Gene

PathCards logo

SuperPathways for PRSS27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRSS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS27: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS27 Gene

Drugs & Compounds for PRSS27 Gene

No Compound Related Data Available

Transcripts for PRSS27 Gene

mRNA/cDNA for PRSS27 Gene

Unigene Clusters for PRSS27 Gene

Protease, serine 27:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PRSS27 - Now 50% OFF >
  • * PRSS27 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRSS27 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS27 Gene

No ASD Table

Relevant External Links for PRSS27 Gene

GeneLoc Exon Structure for
PRSS27
ECgene alternative splicing isoforms for
PRSS27

Expression for PRSS27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS27 Gene

This gene is overexpressed in Esophagus - Mucosa (x28.2), Vagina (x8.3), and Cervix - Ectocervix (x5.8).

Protein differential expression in normal tissues from HIPED for PRSS27 Gene

This gene is overexpressed in Cervix (54.2) and Saliva (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS27 Gene



Protein tissue co-expression partners for PRSS27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRSS27 Gene:

PRSS27

SOURCE GeneReport for Unigene cluster for PRSS27 Gene:

Hs.332878

mRNA Expression by UniProt/SwissProt for PRSS27 Gene:

Q9BQR3-PRS27_HUMAN
Tissue specificity: Expressed predominantly in the pancreas.

Evidence on tissue expression from TISSUES for PRSS27 Gene

  • Skin(4.1)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with PRSS27: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS27 Gene

Orthologs for PRSS27 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS27 35 34
  • 98.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS27 35 34
  • 85.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRSS27 35 34
  • 84.63 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prss27 17 35 34
  • 81.87 (n)
rat
(Rattus norvegicus)
Mammalia Prss27 34
  • 79.32 (n)
oppossum
(Monodelphis domestica)
Mammalia PRSS27 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRSS27 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495333 34
  • 53.04 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100001520 34
  • 50.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004569 34
  • 46.46 (n)
Species where no ortholog for PRSS27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS27 Gene

ENSEMBL:
Gene Tree for PRSS27 (if available)
TreeFam:
Gene Tree for PRSS27 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRSS27: view image

Paralogs for PRSS27 Gene

Pseudogenes.org Pseudogenes for PRSS27 Gene

genes like me logo Genes that share paralogs with PRSS27: view

Variants for PRSS27 Gene

Sequence variations from dbSNP and Humsavar for PRSS27 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000033814 -- 2,721,081(-) C/A upstream_transcript_variant
rs1000050368 -- 2,715,636(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000067796 -- 2,720,993(-) C/A/G/T upstream_transcript_variant
rs1000287616 -- 2,716,415(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000333591 -- 2,716,629(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS27 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV duplication 17116639
esv2760067 CNV gain+loss 17122850
nsv471073 CNV loss 18288195
nsv833123 CNV gain+loss 17160897

Variation tolerance for PRSS27 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS27 Gene

Disorders for PRSS27 Gene

Additional Disease Information for PRSS27

No disorders were found for PRSS27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS27 Gene

Publications for PRSS27 Gene

  1. Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. (PMID: 12441343) Bhagwandin VJ … Caughey GH (The Journal of biological chemistry 2003) 3 4 23 58
  2. The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. (PMID: 18948266) Li W … Kirchhofer D (The Journal of biological chemistry 2009) 3 23 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. (PMID: 23447538) Raman K … Caughey GH (The Journal of biological chemistry 2013) 3 58

Products for PRSS27 Gene

Sources for PRSS27 Gene

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