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Aliases for PRSS27 Gene

Aliases for PRSS27 Gene

  • Protease, Serine 27 2 3 5
  • Pancreasin 2 3 4
  • Marapsin 2 3 4
  • MPN 3 4
  • Channel-Activating Protease 2 3
  • Serine Protease 27 3
  • EC 3.4.21.43 56
  • EC 3.4.21.4 56
  • EC 3.4.21.- 4
  • EC 3.4.21 56
  • CAPH2 3

External Ids for PRSS27 Gene

Previous GeneCards Identifiers for PRSS27 Gene

  • GC16U990229
  • GC16M002704
  • GC16M002705
  • GC16M002733
  • GC16M002768

Summaries for PRSS27 Gene

Entrez Gene Summary for PRSS27 Gene

  • This gene is located within a large protease gene cluster on chromosome 16. It belongs to the group-1 subfamily of serine proteases. The encoded protein is a secreted tryptic serine protease and is expressed mainly in the pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for PRSS27 Gene

PRSS27 (Protease, Serine 27) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS22.

Additional gene information for PRSS27 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS27 Gene

Genomics for PRSS27 Gene

GeneHancer (GH) Regulatory Elements for PRSS27 Gene

Promoters and enhancers for PRSS27 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I002719 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 0.0 -47 2.6 HDGF PKNOX1 ARID4B NEUROD1 SIN3A DMAP1 SLC30A9 ZNF213 E2F8 ZNF207 PRSS27 TIGD7 NME3 CLUAP1 ZNF213-AS1 ZNF75A ZNF174 MTCO1P28 FLYWCH1 MTND1P8
GH16I002723 Enhancer 0.4 ENCODE 550.8 -1.5 -1537 0.2 CEBPB SP7 PRSS27 GC16P002996
GH16I002750 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12 -32.5 -32494 4.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 SRRM2 GC16P003013 SRRM2-AS1 ZNF75A ERVK13-1 TSC2 ZNF263 ENSG00000255513 LOC105371055 SNORA64
GH16I002774 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.2 -56.7 -56703 4.6 CLOCK SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF766 GC16P002987 PIR54527 ENSG00000276791 ELOB MTCO1P28 SRRM2 SRRM2-AS1 TIGD7 PRSS27 CLUAP1
GH16I002911 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10 -191.7 -191742 2.5 HDGF FOXA2 PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 E2F8 FLYWCH1 FLYWCH2 PRSS27 LOC101929566 PRSS22 GC16M002924
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRSS27 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRSS27 gene promoter:

Genomic Locations for PRSS27 Gene

Genomic Locations for PRSS27 Gene
chr16:2,712,418-2,720,578
(GRCh38/hg38)
Size:
8,161 bases
Orientation:
Minus strand
chr16:2,762,419-2,770,552
(GRCh37/hg19)

Genomic View for PRSS27 Gene

Genes around PRSS27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS27 Gene

Proteins for PRSS27 Gene

  • Protein details for PRSS27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQR3-PRS27_HUMAN
    Recommended name:
    Serine protease 27
    Protein Accession:
    Q9BQR3

    Protein attributes for PRSS27 Gene

    Size:
    290 amino acids
    Molecular mass:
    31940 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS27 Gene

Selected DME Specific Peptides for PRSS27 Gene

Q9BQR3:
  • PWQVSIQ
  • VLTAAHC
  • SWGEGCA
  • GDSGGPL
  • SGGPLVC
  • FCGGSLI
  • CWVTGWG
  • CKGDSGG
  • HFCGGSL
  • WVLTAAHCFR
  • LTAAHCF
  • WVLTAAH

Post-translational modifications for PRSS27 Gene

Other Protein References for PRSS27 Gene

Domains & Families for PRSS27 Gene

Gene Families for PRSS27 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRSS27 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQR3

UniProtKB/Swiss-Prot:

PRS27_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS27: view

Function for PRSS27 Gene

Enzyme Numbers (IUBMB) for PRSS27 Gene

Phenotypes From GWAS Catalog for PRSS27 Gene

Gene Ontology (GO) - Molecular Function for PRSS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS27: view
genes like me logo Genes that share phenotypes with PRSS27: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS27

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS27 Gene

Localization for PRSS27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS27 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS27 gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PRSS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0019897 extrinsic component of plasma membrane IBA --
GO:0046658 anchored component of plasma membrane IBA --
genes like me logo Genes that share ontologies with PRSS27: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS27 Gene

Pathways & Interactions for PRSS27 Gene

SuperPathways for PRSS27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRSS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS27: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS27 Gene

Drugs & Compounds for PRSS27 Gene

No Compound Related Data Available

Transcripts for PRSS27 Gene

Unigene Clusters for PRSS27 Gene

Protease, serine 27:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS27 Gene

No ASD Table

Relevant External Links for PRSS27 Gene

GeneLoc Exon Structure for
PRSS27
ECgene alternative splicing isoforms for
PRSS27

Expression for PRSS27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS27 Gene

This gene is overexpressed in Esophagus - Mucosa (x28.2), Vagina (x8.3), and Cervix - Ectocervix (x5.8).

Protein differential expression in normal tissues from HIPED for PRSS27 Gene

This gene is overexpressed in Cervix (54.2) and Saliva (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRSS27 Gene



Protein tissue co-expression partners for PRSS27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRSS27 Gene:

PRSS27

SOURCE GeneReport for Unigene cluster for PRSS27 Gene:

Hs.332878

mRNA Expression by UniProt/SwissProt for PRSS27 Gene:

Q9BQR3-PRS27_HUMAN
Tissue specificity: Expressed predominantly in the pancreas.

Evidence on tissue expression from TISSUES for PRSS27 Gene

  • Skin(4.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with PRSS27: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS27 Gene

Orthologs for PRSS27 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS27 33 34
  • 98.85 (n)
dog
(Canis familiaris)
Mammalia PRSS27 33 34
  • 85.27 (n)
cow
(Bos Taurus)
Mammalia PRSS27 33 34
  • 84.63 (n)
mouse
(Mus musculus)
Mammalia Prss27 33 16 34
  • 81.87 (n)
rat
(Rattus norvegicus)
Mammalia Prss27 33
  • 79.32 (n)
oppossum
(Monodelphis domestica)
Mammalia PRSS27 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRSS27 34
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
ManyToMany
-- 34
  • 48 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495333 33
  • 53.04 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100001520 33
  • 50.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004569 33
  • 46.46 (n)
Species where no ortholog for PRSS27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS27 Gene

ENSEMBL:
Gene Tree for PRSS27 (if available)
TreeFam:
Gene Tree for PRSS27 (if available)

Paralogs for PRSS27 Gene

Pseudogenes.org Pseudogenes for PRSS27 Gene

genes like me logo Genes that share paralogs with PRSS27: view

Variants for PRSS27 Gene

Sequence variations from dbSNP and Humsavar for PRSS27 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000033814 -- 2,721,081(-) C/A upstream_transcript_variant
rs1000050368 -- 2,715,636(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000067796 -- 2,720,993(-) C/G/T upstream_transcript_variant
rs1000287616 -- 2,716,415(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000333591 -- 2,716,629(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS27 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV duplication 17116639
esv2760067 CNV gain+loss 17122850
nsv471073 CNV loss 18288195
nsv833123 CNV gain+loss 17160897

Variation tolerance for PRSS27 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS27 Gene

Disorders for PRSS27 Gene

Additional Disease Information for PRSS27

No disorders were found for PRSS27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS27 Gene

Publications for PRSS27 Gene

  1. Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. (PMID: 12441343) Bhagwandin VJ … Caughey GH (The Journal of biological chemistry 2003) 3 4 22 58
  2. The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. (PMID: 18948266) Li W … Kirchhofer D (The Journal of biological chemistry 2009) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. (PMID: 23447538) Raman K … Caughey GH (The Journal of biological chemistry 2013) 3 58

Products for PRSS27 Gene

Sources for PRSS27 Gene

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