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Aliases for PRSS23 Gene

Aliases for PRSS23 Gene

  • Serine Protease 23 2 3 4 5
  • Putative Secreted Protein Zsig13 3 4
  • Protease, Serine 23 2 3
  • ZSIG13 3 4
  • Serine Protease, Umbilical Endothelium 3
  • EC 56
  • EC 3.4.21.- 4
  • EC 3.4.21 56
  • SIG13 3
  • SPUVE 3

External Ids for PRSS23 Gene

Previous GeneCards Identifiers for PRSS23 Gene

  • GC11P086189
  • GC11P086511

Summaries for PRSS23 Gene

Entrez Gene Summary for PRSS23 Gene

  • This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for PRSS23 Gene

PRSS23 (Serine Protease 23) is a Protein Coding gene. Diseases associated with PRSS23 include Exudative Vitreoretinopathy and Exudative Vitreoretinopathy 1. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS35.

Gene Wiki entry for PRSS23 Gene

Additional gene information for PRSS23 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS23 Gene

Genomics for PRSS23 Gene

GeneHancer (GH) Regulatory Elements for PRSS23 Gene

Promoters and enhancers for PRSS23 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J086798 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 607.9 +12.3 12276 9.3 CTCF MAFK POLR2A PRDM1 IKZF1 GLIS2 ZNF600 PRDM10 IKZF2 PATZ1 PRSS23 ME3 ENSG00000255250 ENSG00000271318
GH11J086669 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 600.1 -119.1 -119131 3.9 ZNF652 NCOA3 SP1 CTCF FOXA2 CEBPB ZFX ATF3 RNF2 MXI1 ME3 PRSS23 PIR51863 GC11M086573
GH11J086791 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.0 41 1.8 NCOA3 MAFK SP7 CREB1 PKNOX1 PRDM10 ZIC2 NFE2L2 ZEB2 ZNF639 PRSS23 ENSG00000255250 ENSG00000271318
GH11J086809 Promoter 0.5 EPDnew 600.4 +18.0 17982 0.1 PRSS23 ENSG00000271318
GH11J086792 Enhancer 0.3 Ensembl 600.7 +1.2 1242 0.2 MZF1 PRSS23 ENSG00000255250 ENSG00000271318
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRSS23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRSS23 gene promoter:
  • AREB6
  • Evi-1
  • FOXL1
  • GR
  • GR-alpha
  • GR-beta
  • STAT1
  • STAT1alpha
  • STAT1beta
  • YY1

Genomic Locations for PRSS23 Gene

Genomic Locations for PRSS23 Gene
161,852 bases
Plus strand
161,852 bases
Plus strand

Genomic View for PRSS23 Gene

Genes around PRSS23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS23 Gene

Proteins for PRSS23 Gene

  • Protein details for PRSS23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease 23
    Protein Accession:
    Secondary Accessions:
    • B2RDJ1
    • B4E2J3
    • Q6IBI0

    Protein attributes for PRSS23 Gene

    383 amino acids
    Molecular mass:
    43001 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRSS23 Gene


neXtProt entry for PRSS23 Gene

Selected DME Specific Peptides for PRSS23 Gene


Post-translational modifications for PRSS23 Gene

  • Glycosylation at isoforms=293, posLast=7373, and isoforms=2207
  • Ubiquitination at isoforms=50
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PRS23_HUMAN (1736)

Other Protein References for PRSS23 Gene

Domains & Families for PRSS23 Gene

Gene Families for PRSS23 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRSS23 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51190, highly similar to Serine protease 23 (EC 3.4.21.-) (B4E2J3_HUMAN)
  • Putative secreted protein Zsig13 (PRS23_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS23: view

Function for PRSS23 Gene

Enzyme Numbers (IUBMB) for PRSS23 Gene

Phenotypes From GWAS Catalog for PRSS23 Gene

Gene Ontology (GO) - Molecular Function for PRSS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS23: view
genes like me logo Genes that share phenotypes with PRSS23: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PRSS23 - Now 50% OFF >
  • * PRSS23 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRSS23 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRSS23 Gene

Localization for PRSS23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS23 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS23 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for PRSS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with PRSS23: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS23 Gene

Pathways & Interactions for PRSS23 Gene

PathCards logo

SuperPathways for PRSS23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRSS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PRSS23: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS23 Gene

Drugs & Compounds for PRSS23 Gene

No Compound Related Data Available

Transcripts for PRSS23 Gene

Unigene Clusters for PRSS23 Gene

Protease, serine, 23:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PRSS23 - Now 50% OFF >
  • * PRSS23 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRSS23 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS23 Gene

ExUns: 1a · 1b ^ 2a · 2b

Relevant External Links for PRSS23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRSS23 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (47.7) and Amniocyte (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRSS23 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRSS23 Gene:


SOURCE GeneReport for Unigene cluster for PRSS23 Gene:


Evidence on tissue expression from TISSUES for PRSS23 Gene

  • Nervous system(3.9)
  • Lung(3.2)
  • Pancreas(2.6)
  • Intestine(2.5)
genes like me logo Genes that share expression patterns with PRSS23: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS23 Gene

Orthologs for PRSS23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRSS23 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRSS23 35 34
  • 99.56 (n)
(Canis familiaris)
Mammalia PRSS23 35 34
  • 88.54 (n)
(Bos Taurus)
Mammalia PRSS23 35 34
  • 87.73 (n)
(Mus musculus)
Mammalia Prss23 17 35 34
  • 86.21 (n)
(Monodelphis domestica)
Mammalia PRSS23 35
  • 86 (a)
(Rattus norvegicus)
Mammalia Prss23 34
  • 85.47 (n)
(Ornithorhynchus anatinus)
Mammalia PRSS23 35
  • 82 (a)
(Gallus gallus)
Aves PRSS23 35 34
  • 78.21 (n)
(Anolis carolinensis)
Reptilia PRSS23 35
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prss23 34
  • 70.9 (n)
(Danio rerio)
Actinopterygii PRSS23 35
  • 49 (a)
wufb01h12 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8589 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
Species where no ortholog for PRSS23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS23 Gene

Gene Tree for PRSS23 (if available)
Gene Tree for PRSS23 (if available)
Evolutionary constrained regions (ECRs) for PRSS23: view image

Paralogs for PRSS23 Gene

Paralogs for PRSS23 Gene

(1) SIMAP similar genes for PRSS23 Gene using alignment to 5 proteins:

  • B4E2J3_HUMAN
genes like me logo Genes that share paralogs with PRSS23: view

Variants for PRSS23 Gene

Sequence variations from dbSNP and Humsavar for PRSS23 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs104894223 pathogenic, Retinopathy of prematurity 86,951,990(+) T/C genic_downstream_transcript_variant, non_coding_transcript_variant
rs10898563 benign, Familial exudative vitreoretinopathy 86,948,171(+) A/G genic_downstream_transcript_variant, intron_variant
rs11234890 likely-benign, Familial exudative vitreoretinopathy 86,948,482(+) G/A genic_downstream_transcript_variant, intron_variant
rs115341334 likely-benign, Familial exudative vitreoretinopathy 86,947,442(+) T/C genic_downstream_transcript_variant, intron_variant
rs115557428 likely-benign, Familial exudative vitreoretinopathy 86,948,600(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS23 Gene

Variant ID Type Subtype PubMed ID
esv2658766 CNV deletion 23128226
esv2666085 CNV deletion 23128226
esv27019 CNV loss 19812545
esv2744857 CNV deletion 23290073
esv2744858 CNV deletion 23290073
esv2760199 CNV loss 21179565
esv3334201 CNV insertion 20981092
esv3548100 CNV deletion 23714750
esv3579789 CNV loss 25503493
esv3627099 CNV gain 21293372
esv3627105 CNV loss 21293372
esv3627106 CNV loss 21293372
esv3627107 CNV loss 21293372
esv3627108 CNV loss 21293372
esv3627109 CNV loss 21293372
esv3627110 CNV loss 21293372
esv988093 CNV gain 20482838
nsv1049157 CNV gain 25217958
nsv1076378 CNV duplication 25765185
nsv1143549 CNV deletion 24896259
nsv1144582 CNV deletion 24896259
nsv428263 CNV loss 18775914
nsv521505 CNV gain 19592680
nsv523704 CNV loss 19592680
nsv524804 CNV loss 19592680
nsv975959 CNV duplication 23825009

Variation tolerance for PRSS23 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS23 Gene

Disorders for PRSS23 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRSS23 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
exudative vitreoretinopathy
  • exudative vitreoretinopathy 1
exudative vitreoretinopathy 1
  • evr1
melanoma, cutaneous malignant 1
  • melanoma, cutaneous malignant, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PRSS23

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRSS23: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS23 Gene

Publications for PRSS23 Gene

  1. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J … ENGAGE Consortium (PLoS genetics 2010) 3 45 58
  2. The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies. (PMID: 16870946) Miyakoshi K … Hennebold JD (Biology of reproduction 2006) 3 23 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58

Products for PRSS23 Gene

Sources for PRSS23 Gene

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