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Aliases for PRSS22 Gene

Aliases for PRSS22 Gene

  • Serine Protease 22 2 3 4 5
  • Brain-Specific Serine Protease 4 2 3 4
  • Protease, Serine 22 2 3
  • Serine Protease 26 3 4
  • Tryptase Epsilon 3 4
  • BSSP-4 3 4
  • Protease, Serine S1 Family Member 22 3
  • EC 3.4.21.- 4
  • EC 3.4.21 56
  • Prosemin 3
  • SP001LA 3
  • HBSSP-4 3
  • PRSS26 4
  • BSSP4 4

External Ids for PRSS22 Gene

Previous GeneCards Identifiers for PRSS22 Gene

  • GC16M002923
  • GC16M002903
  • GC16M002842
  • GC16M002902
  • GC16M002869

Summaries for PRSS22 Gene

Entrez Gene Summary for PRSS22 Gene

  • This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRSS22 Gene

PRSS22 (Serine Protease 22) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS21.

UniProtKB/Swiss-Prot for PRSS22 Gene

  • Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA.

Gene Wiki entry for PRSS22 Gene

Additional gene information for PRSS22 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS22 Gene

Genomics for PRSS22 Gene

GeneHancer (GH) Regulatory Elements for PRSS22 Gene

Promoters and enhancers for PRSS22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J002857 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 626.1 +0.8 825 2.8 NCOA3 CDC5L ZBTB7A POLR2A EGR1 HDGF CREB1 ZNF600 TARDBP CTCF PRSS22 ENSG00000263325 PRSS30P ZNF213-AS1 ENSG00000260778 ZNF75A FLYWCH1
GH16J002840 Promoter/Enhancer 1.4 Ensembl ENCODE 25.5 +17.0 17018 3.2 CTCF MLLT1 TRIM24 CREM EGR1 MTA1 GMEB1 PKNOX1 IKZF1 RFX1 PRSS30P PRSS22 ENSG00000263280 ZG16B
GH16J002750 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11 +105.5 105462 4.9 ZNF652 SP1 ELF3 ZFX ZKSCAN8 MNT SIX5 ZNF148 NKRF POLR2A SRRM2 GC16P003906 SRRM2-AS1 ZNF75A ERVK13-1 ZNF263 TSC2 ZNF213-AS1 E4F1 ENSG00000261938
GH16J002881 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.3 -24.4 -24412 2.9 SP1 ZFX ZNF148 NKRF POLR2A GTF2F1 ZNF384 ZNF687 NFIB FOS FLYWCH2 TBL3 FLYWCH1 ENSG00000261938 CREBBP ZNF598 TIGD7 SNHG19 ZNF597 CLUAP1
GH16J002903 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 12.5 -46.8 -46842 3.7 ZNF652 ZFX SP1 CTCF ELF3 MNT NKRF POLR2A MLLT1 CEBPG ZNF597 CREBBP TBL3 ENSG00000261938 ZNF263 ZNF75A FLYWCH2 E4F1 ZNF213-AS1 ZNF174
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRSS22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRSS22 gene promoter:
  • AP-1
  • Cart-1
  • FOXD3
  • HEN1
  • MyoD
  • Pax-2
  • Pax-2a
  • STAT1
  • STAT1alpha
  • ZIC2

Genomic Locations for PRSS22 Gene

Genomic Locations for PRSS22 Gene
chr16:2,852,727-2,858,630
(GRCh38/hg38)
Size:
5,904 bases
Orientation:
Minus strand
chr16:2,902,728-2,908,171
(GRCh37/hg19)
Size:
5,444 bases
Orientation:
Minus strand

Genomic View for PRSS22 Gene

Genes around PRSS22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS22 Gene

Proteins for PRSS22 Gene

  • Protein details for PRSS22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZN4-BSSP4_HUMAN
    Recommended name:
    Brain-specific serine protease 4
    Protein Accession:
    Q9GZN4
    Secondary Accessions:
    • O43342
    • Q6UXE0

    Protein attributes for PRSS22 Gene

    Size:
    317 amino acids
    Molecular mass:
    33732 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB93671.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAQ88762.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PRSS22 Gene

Selected DME Specific Peptides for PRSS22 Gene

Q9GZN4:
  • SWGEGCA
  • GDSGGPL
  • DIALVRL
  • CWISGWG

Post-translational modifications for PRSS22 Gene

Other Protein References for PRSS22 Gene

Domains & Families for PRSS22 Gene

Gene Families for PRSS22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRSS22 Gene

GenScript: Design optimal peptide antigens:
  • Tryptase epsilon (BSSP4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZN4

UniProtKB/Swiss-Prot:

BSSP4_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS22: view

Function for PRSS22 Gene

Molecular function for PRSS22 Gene

UniProtKB/Swiss-Prot Function:
Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA.

Enzyme Numbers (IUBMB) for PRSS22 Gene

Phenotypes From GWAS Catalog for PRSS22 Gene

Gene Ontology (GO) - Molecular Function for PRSS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS22: view
genes like me logo Genes that share phenotypes with PRSS22: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS22

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS22

Clone Products

  • Applied Biological Materials (abm): Clones for PRSS22 - Now 50% OFF >
  • * PRSS22 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRSS22 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRSS22 Gene

Localization for PRSS22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS22 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS22 gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 2
mitochondrion 0
peroxisome 0
endoplasmic reticulum 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRSS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0019897 extrinsic component of plasma membrane IBA 21873635
GO:0046658 anchored component of plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with PRSS22: view

Pathways & Interactions for PRSS22 Gene

PathCards logo

SuperPathways for PRSS22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRSS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS22: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS22 Gene

Drugs & Compounds for PRSS22 Gene

(1) Drugs for PRSS22 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PMSF Pharma Serine proteinases inhibitor, irreversible 0

(1) ApexBio Compounds for PRSS22 Gene

Compound Action Cas Number
PMSF Serine proteinases inhibitor, irreversible 329-98-6
genes like me logo Genes that share compounds with PRSS22: view

Drug Products

Transcripts for PRSS22 Gene

mRNA/cDNA for PRSS22 Gene

Unigene Clusters for PRSS22 Gene

Protease, serine, 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS22

Clone Products

  • Applied Biological Materials (abm): Clones for PRSS22 - Now 50% OFF >
  • * PRSS22 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRSS22 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS22 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - - - - -
SP3: - -
SP4:
SP5:

Relevant External Links for PRSS22 Gene

GeneLoc Exon Structure for
PRSS22
ECgene alternative splicing isoforms for
PRSS22

Expression for PRSS22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS22 Gene

This gene is overexpressed in Esophagus - Mucosa (x15.1), Minor Salivary Gland (x12.8), and Cervix - Ectocervix (x5.1).

Protein differential expression in normal tissues from HIPED for PRSS22 Gene

This gene is overexpressed in Esophagus (35.0) and Islet of Langerhans (34.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS22 Gene



Protein tissue co-expression partners for PRSS22 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRSS22 Gene:

PRSS22

SOURCE GeneReport for Unigene cluster for PRSS22 Gene:

Hs.459709

mRNA Expression by UniProt/SwissProt for PRSS22 Gene:

Q9GZN4-BSSP4_HUMAN
Tissue specificity: Expressed abundantly in the epithelial cells of the airways, including trachea, esophagus and fetal lung. Scarce in adult lung. Expressed at low levels in placenta, pancreas, prostate and thyroid gland.

Evidence on tissue expression from TISSUES for PRSS22 Gene

  • Pancreas(4.2)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with PRSS22: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS22 Gene

Orthologs for PRSS22 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS22 35 34
  • 99.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS22 35 34
  • 83.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRSS22 35 34
  • 83.05 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prss22 17 35 34
  • 80.35 (n)
rat
(Rattus norvegicus)
Mammalia Prss22 34
  • 79.14 (n)
oppossum
(Monodelphis domestica)
Mammalia PRSS22 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRSS22 35
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8170 36 34
  • 48.45 (n)
Sb 36
  • 37 (a)
CG1299 36
  • 33 (a)
CG9733 36
  • 33 (a)
CG6865 36
  • 32 (a)
CG7432 36
  • 32 (a)
CG8172 36
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea C07G1.1 36
  • 35 (a)
Species where no ortholog for PRSS22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PRSS22 Gene

ENSEMBL:
Gene Tree for PRSS22 (if available)
TreeFam:
Gene Tree for PRSS22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRSS22: view image

Paralogs for PRSS22 Gene

Pseudogenes.org Pseudogenes for PRSS22 Gene

genes like me logo Genes that share paralogs with PRSS22: view

Variants for PRSS22 Gene

Sequence variations from dbSNP and Humsavar for PRSS22 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs193920873 uncertain-significance, Malignant tumor of prostate 2,853,241(-) C/G/T coding_sequence_variant, missense_variant
rs1000000957 -- 2,859,525(-) C/T upstream_transcript_variant
rs1000036132 -- 2,859,310(-) C/G upstream_transcript_variant
rs1000268685 -- 2,853,518(-) T/C intron_variant
rs1000508984 -- 2,853,754(-) G/A/C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS22 Gene

Variant ID Type Subtype PubMed ID
nsv1712 CNV insertion 18451855
nsv509587 CNV insertion 20534489
nsv952905 CNV deletion 24416366

Variation tolerance for PRSS22 Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS22 Gene

Disorders for PRSS22 Gene

Additional Disease Information for PRSS22

No disorders were found for PRSS22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS22 Gene

Publications for PRSS22 Gene

  1. Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells. (PMID: 11602603) Wong GW … Stevens RL (The Journal of biological chemistry 2001) 2 3 4 23 58
  2. Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22. (PMID: 15701722) Yasuda S … Stevens RL (Blood 2005) 2 3 23 58
  3. A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells. (PMID: 16176265) Mitsui S … Yamaguchi N (The FEBS journal 2005) 3 23 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58

Products for PRSS22 Gene

Sources for PRSS22 Gene

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