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Aliases for PRSS22 Gene

Aliases for PRSS22 Gene

  • Protease, Serine 22 2 3 5
  • Brain-Specific Serine Protease 4 2 3
  • Serine Protease 26 3 4
  • Tryptase Epsilon 3 4
  • BSSP-4 3 4
  • Protease, Serine S1 Family Member 22 3
  • Serine Protease 22 4
  • EC 3.4.21.- 4
  • EC 3.4.21 56
  • Prosemin 3
  • SP001LA 3
  • HBSSP-4 3
  • PRSS26 4
  • BSSP4 4

External Ids for PRSS22 Gene

Previous GeneCards Identifiers for PRSS22 Gene

  • GC16M002923
  • GC16M002903
  • GC16M002842
  • GC16M002902
  • GC16M002869

Summaries for PRSS22 Gene

Entrez Gene Summary for PRSS22 Gene

  • This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRSS22 Gene

PRSS22 (Protease, Serine 22) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS27.

UniProtKB/Swiss-Prot for PRSS22 Gene

  • Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA.

Gene Wiki entry for PRSS22 Gene

Additional gene information for PRSS22 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS22 Gene

Genomics for PRSS22 Gene

GeneHancer (GH) Regulatory Elements for PRSS22 Gene

Promoters and enhancers for PRSS22 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I002856 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 576.2 +0.7 680 2.6 HDAC1 HDGF PKNOX1 CLOCK RARA ZNF335 ZNF366 ZNF207 FOS RCOR1 PRSS22 ENSG00000263325 PRSS30P ZNF213-AS1 LOC106660606 ZNF75A FLYWCH1
GH16I002840 Enhancer 1.1 Ensembl ENCODE 25.5 +17.0 17018 3.2 PKNOX1 ATF1 ARNT ZNF2 E2F8 ZNF143 ATF7 RUNX3 NCOA1 REST PRSS30P PRSS22 LOC101929566 ZG16B
GH16I002750 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11 +105.6 105558 4.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 SRRM2 GC16P003013 SRRM2-AS1 ZNF75A ERVK13-1 TSC2 ZNF263 ENSG00000255513 LOC105371055 SNORA64
GH16I002881 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.3 -24.5 -24521 2.7 HDGF PKNOX1 CLOCK ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B FLYWCH2 TBL3 FLYWCH1 ENSG00000261938 CREBBP ZNF598 TIGD7 SNHG19 ZNF597 CLUAP1
GH16I002903 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -47.0 -46977 4 HDGF PKNOX1 CLOCK SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF597 CREBBP TBL3 FLYWCH2 SRRM2 ENSG00000261938 TIGD7 ZNF598 FLYWCH1 ZNF263
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRSS22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRSS22 gene promoter:

Genomic Locations for PRSS22 Gene

Genomic Locations for PRSS22 Gene
5,904 bases
Minus strand

Genomic View for PRSS22 Gene

Genes around PRSS22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS22 Gene

Proteins for PRSS22 Gene

  • Protein details for PRSS22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Brain-specific serine protease 4
    Protein Accession:
    Secondary Accessions:
    • O43342
    • Q6UXE0

    Protein attributes for PRSS22 Gene

    317 amino acids
    Molecular mass:
    33732 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB93671.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAQ88762.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PRSS22 Gene

Selected DME Specific Peptides for PRSS22 Gene


Post-translational modifications for PRSS22 Gene

Other Protein References for PRSS22 Gene

Antibody Products

  • R&D Systems Antibodies for PRSS22 (Tryptase epsilon/BSSP-4)
  • Abcam antibodies for PRSS22

Domains & Families for PRSS22 Gene

Gene Families for PRSS22 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRSS22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS22: view

Function for PRSS22 Gene

Molecular function for PRSS22 Gene

UniProtKB/Swiss-Prot Function:
Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA.

Enzyme Numbers (IUBMB) for PRSS22 Gene

Gene Ontology (GO) - Molecular Function for PRSS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS22: view
genes like me logo Genes that share phenotypes with PRSS22: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS22

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRSS22 Gene

Localization for PRSS22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS22 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS22 gene
Compartment Confidence
plasma membrane 4
extracellular 4
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRSS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0019897 extrinsic component of plasma membrane IBA --
GO:0046658 anchored component of plasma membrane IBA --
genes like me logo Genes that share ontologies with PRSS22: view

Pathways & Interactions for PRSS22 Gene

SuperPathways for PRSS22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRSS22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRSS22: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS22 Gene

Drugs & Compounds for PRSS22 Gene

(1) Drugs for PRSS22 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PMSF Pharma Serine proteinases inhibitor, irreversible 0

(1) ApexBio Compounds for PRSS22 Gene

Compound Action Cas Number
PMSF Serine proteinases inhibitor, irreversible 329-98-6
genes like me logo Genes that share compounds with PRSS22: view

Drug Products

Transcripts for PRSS22 Gene

Unigene Clusters for PRSS22 Gene

Protease, serine, 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS22 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - - - - -
SP3: - -

Relevant External Links for PRSS22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRSS22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS22 Gene

This gene is overexpressed in Esophagus - Mucosa (x15.1), Minor Salivary Gland (x12.8), and Cervix - Ectocervix (x5.1).

Protein differential expression in normal tissues from HIPED for PRSS22 Gene

This gene is overexpressed in Esophagus (35.0) and Islet of Langerhans (34.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRSS22 Gene

Protein tissue co-expression partners for PRSS22 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRSS22 Gene:


SOURCE GeneReport for Unigene cluster for PRSS22 Gene:


mRNA Expression by UniProt/SwissProt for PRSS22 Gene:

Tissue specificity: Expressed abundantly in the epithelial cells of the airways, including trachea, esophagus and fetal lung. Scarce in adult lung. Expressed at low levels in placenta, pancreas, prostate and thyroid gland.

Evidence on tissue expression from TISSUES for PRSS22 Gene

  • Pancreas(4.2)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with PRSS22: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS22 Gene

Orthologs for PRSS22 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRSS22 33 34
  • 99.26 (n)
(Canis familiaris)
Mammalia PRSS22 33 34
  • 83.33 (n)
(Bos Taurus)
Mammalia PRSS22 33 34
  • 83.05 (n)
(Mus musculus)
Mammalia Prss22 33 16 34
  • 80.35 (n)
(Rattus norvegicus)
Mammalia Prss22 33
  • 79.14 (n)
(Monodelphis domestica)
Mammalia PRSS22 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia PRSS22 34
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 46 (a)
-- 34
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8170 35 33
  • 48.45 (n)
Sb 35
  • 37 (a)
CG1299 35
  • 33 (a)
CG9733 35
  • 33 (a)
CG6865 35
  • 32 (a)
CG7432 35
  • 32 (a)
CG8172 35
  • 31 (a)
(Caenorhabditis elegans)
Secernentea C07G1.1 35
  • 35 (a)
Species where no ortholog for PRSS22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PRSS22 Gene

Gene Tree for PRSS22 (if available)
Gene Tree for PRSS22 (if available)

Paralogs for PRSS22 Gene Pseudogenes for PRSS22 Gene

genes like me logo Genes that share paralogs with PRSS22: view

Variants for PRSS22 Gene

Sequence variations from dbSNP and Humsavar for PRSS22 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs193920873 uncertain-significance, Malignant tumor of prostate 2,853,241(-) C/G/T coding_sequence_variant, missense_variant
rs1000000957 -- 2,859,525(-) C/T upstream_transcript_variant
rs1000036132 -- 2,859,310(-) C/G upstream_transcript_variant
rs1000268685 -- 2,853,518(-) T/C intron_variant
rs1000508984 -- 2,853,754(-) G/C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS22 Gene

Variant ID Type Subtype PubMed ID
nsv1712 CNV insertion 18451855
nsv509587 CNV insertion 20534489
nsv952905 CNV deletion 24416366

Variation tolerance for PRSS22 Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS22 Gene

Disorders for PRSS22 Gene

Additional Disease Information for PRSS22

No disorders were found for PRSS22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRSS22 Gene

Publications for PRSS22 Gene

  1. Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells. (PMID: 11602603) Wong GW … Stevens RL (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22. (PMID: 15701722) Yasuda S … Stevens RL (Blood 2005) 2 3 22 58
  3. A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells. (PMID: 16176265) Mitsui S … Yamaguchi N (The FEBS journal 2005) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58

Products for PRSS22 Gene

Sources for PRSS22 Gene

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