This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic fea... See more...

Aliases for PRSS2 Gene

Aliases for PRSS2 Gene

  • Serine Protease 2 2 3 4 5
  • TRY2 2 3 4
  • Anionic Trypsinogen 3 4
  • Protease, Serine 2 2 3
  • EC 3.4.21.4 4 50
  • Trypsin II 3 4
  • Trypsin-2 3 4
  • TRYP2 3 4
  • Protease Serine 2 Preproprotein 3
  • Protease, Serine, 2 (Trypsin 2) 3
  • Trypsinogen 2 3
  • Trypsin 2 2
  • EC 3.4.21 50
  • PRSS2 5
  • TRY8 3

External Ids for PRSS2 Gene

Previous GeneCards Identifiers for PRSS2 Gene

  • GC07P140772
  • GC07P140731
  • GC07P141821
  • GC07P141899
  • GC07P141902
  • GC07P141676
  • GC07P141990
  • GC07P142167
  • GC07P142178
  • GC07P142457
  • GC07P142298
  • GC07Pg41870
  • GC07P9T0974
  • GC07P9T0097
  • GC07P142858
  • GC07P142980
  • GC07P144225
  • GC07P144360
  • GC07P144489
  • GC07P144731
  • GC07P143131
  • GC07P143194
  • GC07P143390
  • GC07P143536
  • GC07P143668
  • GC07P143809
  • GC07P143947
  • GC07P144082
  • GC07P144959
  • GC07P145219

Summaries for PRSS2 Gene

Entrez Gene Summary for PRSS2 Gene

  • This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]

GeneCards Summary for PRSS2 Gene

PRSS2 (Serine Protease 2) is a Protein Coding gene. Diseases associated with PRSS2 include Pancreatitis, Hereditary and Pancreatitis. Among its related pathways are Degradation of the extracellular matrix and Salivary secretion. Gene Ontology (GO) annotations related to this gene include calcium ion binding and serine-type endopeptidase activity. An important paralog of this gene is PRSS1.

UniProtKB/Swiss-Prot Summary for PRSS2 Gene

  • In the ileum, may be involved in defensin processing, including DEFA5.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRSS2 Gene

Genomics for PRSS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRSS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J142760 Promoter/Enhancer 0.9 EPDnew Ensembl 250.7 +0.4 402 1.2 ZEB2 ATF4 ARID1B ATF3 FOS CTBP1 IKZF1 PRDM10 ZSCAN29 SMARCA4 PRSS3P1 PRSS2 lnc-PRSS1-2 EPHB6 TRBD1 TRB lnc-PRSS2-6
GH07J142748 Promoter/Enhancer 0.7 EPDnew ENCODE 0.4 -11.1 -11079 0.9 ATF4 EP300 HSALNG0061904 NONHSAG049014.2-001 PRSS1 TRBV28 PRSS2 lnc-PRSS2-6 TRB
GH07J142742 Enhancer 0.7 Ensembl ENCODE 0.4 -19.3 -19297 2.6 SMC3 ZNF316 CTCF MAFG MAFK ETV6 SCRT2 EMSY TRBV29-1 PRSS1 TRBV28 HSALNG0061904 NONHSAG049014.2-001 PRSS2 lnc-PRSS2-6 TRB
GH07J142754 Enhancer 0.4 Ensembl ENCODE 0.4 -5.8 -5776 0.9 CBFA2T2 TRBV28 HSALNG0061904 PRSS2 PRSS1 lnc-PRSS2-6 TRB
GH07J142750 Enhancer 0.3 Ensembl 0.4 -10.0 -9997 0.8 GLIS1 EP300 HSALNG0061904 NONHSAG049014.2-001 PRSS2 PRSS1 lnc-PRSS2-6 TRB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRSS2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for PRSS2 Gene

Latest Assembly
chr7:142,760,398-142,774,564
(GRCh38/hg38)
Size:
14,167 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr7(ALT_REF_LOCI_1):793,943-797,533 (+)

Genomic View for PRSS2 Gene

Genes around PRSS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS2 Gene

Proteins for PRSS2 Gene

  • Protein details for PRSS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07478-TRY2_HUMAN
    Recommended name:
    Trypsin-2
    Protein Accession:
    P07478

    Protein attributes for PRSS2 Gene

    Size:
    247 amino acids
    Molecular mass:
    26488 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS2 Gene

Selected DME Specific Peptides for PRSS2 Gene

P07478:
  • VSWGYGCA
  • IQVRLGE
  • GADYPDEL
  • LQGIVSWG
  • SGWGNTLS
  • EGGKDSC
  • GYHFCGGSLI
  • GFLEGGKDSC
  • VRLGEHNI
  • FCGGSLI
  • LQCLDAP
  • PGVYTKV
  • DSCQGDSGG
  • CEASYPG
  • HFCGGSL
  • VRLGEHN
  • CQGDSGGP
  • QGIVSWG
  • DKIVGGY
  • PGVYTKVYNYV

Post-translational modifications for PRSS2 Gene

  • Sulfated on tyrosine.
  • Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRSS2 Gene

Domains & Families for PRSS2 Gene

Gene Families for PRSS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for PRSS2 Gene

InterPro:
Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature

Suggested Antigen Peptide Sequences for PRSS2 Gene

GenScript: Design optimal peptide antigens:
  • Protease, serine, 2 (Trypsin 2) (Q3SY20_HUMAN)
  • Trypsinogen E (Q5NV56_HUMAN)
  • PRSS2 protein (Q6PK75_HUMAN)
  • Trypsin II (TRY2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P07478

UniProtKB/Swiss-Prot:

TRY2_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS2: view

Function for PRSS2 Gene

Molecular function for PRSS2 Gene

UniProtKB/Swiss-Prot Function:
In the ileum, may be involved in defensin processing, including DEFA5.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4;.
GENATLAS Biochemistry:
protease serine 2,trypsin 2,expressed in pancreas

Enzyme Numbers (IUBMB) for PRSS2 Gene

Phenotypes From GWAS Catalog for PRSS2 Gene

Gene Ontology (GO) - Molecular Function for PRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IBA,IDA 12709065
GO:0005509 calcium ion binding IDA 12709065
GO:0005515 protein binding IPI 16192646
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with PRSS2: view
genes like me logo Genes that share phenotypes with PRSS2: view

Human Phenotype Ontology for PRSS2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PRSS2 Gene

MGI Knock Outs for PRSS2:
  • Prss2 Prss2<tm1.1(KOMP)Vlcg>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS2

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for PRSS2 Gene

Localization for PRSS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS2 Gene

Secreted, extracellular space.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA,IMP 16192646
GO:0031012 extracellular matrix TAS 12731883
GO:0035578 azurophil granule lumen TAS --
genes like me logo Genes that share ontologies with PRSS2: view

No data available for Subcellular locations from COMPARTMENTS for PRSS2 Gene

Pathways & Interactions for PRSS2 Gene

genes like me logo Genes that share pathways with PRSS2: view

Interacting Proteins for PRSS2 Gene

SIGNOR curated interactions for PRSS2 Gene

Activates:

Gene Ontology (GO) - Biological Process for PRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA,IDA 12731883
GO:0007586 digestion IEA --
GO:0019730 antimicrobial humoral response TAS --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030307 positive regulation of cell growth TAS 12731883
genes like me logo Genes that share ontologies with PRSS2: view

Drugs & Compounds for PRSS2 Gene

(16) Drugs for PRSS2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprotinin Approved, Investigational, Withdrawn Pharma Inhibitor of bovine pancreatic trypsin 28
Isopropyl alcohol Approved, Investigational Pharma 0
Benzylamine Experimental Pharma Target 0
3-Phenylpropylamine Experimental Pharma Target 0
benzamidine Experimental Pharma Target 0

(1) Additional Compounds for PRSS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) ApexBio Compounds for PRSS2 Gene

Compound Action Cas Number
AEBSF.HCl Serine protease inhibitor 30827-99-7
Aprotinin Inhibitor of bovine pancreatic trypsin 9087-70-1
Leupeptin, Microbial Inhibitor of serine and cysteine proteases 103476-89-7
Nafamostat Mesylate(FUT-175) Serine protease inhibitor 82956-11-4
genes like me logo Genes that share compounds with PRSS2: view

Drug products for research

Transcripts for PRSS2 Gene

mRNA/cDNA for PRSS2 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS2

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS2 Gene

No ASD Table

Relevant External Links for PRSS2 Gene

GeneLoc Exon Structure for
PRSS2

Expression for PRSS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRSS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRSS2 Gene

This gene is overexpressed in Pancreatic juice (47.9) and Pancreas (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS2 Gene



Protein tissue co-expression partners for PRSS2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRSS2

SOURCE GeneReport for Unigene cluster for PRSS2 Gene:

Hs.726742

mRNA Expression by UniProt/SwissProt for PRSS2 Gene:

P07478-TRY2_HUMAN
Tissue specificity: Expressed in Paneth cells, at the base of small intestinal crypts.

Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • nervous
  • respiratory
  • urinary
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • head
Thorax:
  • diaphragm
  • esophagus
  • heart
  • lung
Abdomen:
  • intestine
  • kidney
  • large intestine
  • pancreas
  • small intestine
  • stomach
General:
  • blood
  • blood vessel
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • white blood cell
genes like me logo Genes that share expression patterns with PRSS2: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Evidence on tissue expression from TISSUES for PRSS2 Gene

Orthologs for PRSS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100615529 29
  • 96.71 (n)
Dog
(Canis familiaris)
Mammalia LOC100686744 29
  • 85.43 (n)
Cow
(Bos Taurus)
Mammalia PRSS2 29
  • 84.08 (n)
Rat
(Rattus norvegicus)
Mammalia Prss1 29
  • 81.44 (n)
Mouse
(Mus musculus)
Mammalia Prss2 29 16
  • 81.03 (n)
Chicken
(Gallus gallus)
Aves PRSS2 29
  • 70.85 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia try10 29
  • 68.59 (n)
Str.8261 29
Zebrafish
(Danio rerio)
Actinopterygii si:ch73-103b2.3 29
  • 69.06 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8654 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009966 29
  • 51.73 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Try29F 31
  • 43 (a)
CG18735 31
  • 42 (a)
CG4386 31
  • 42 (a)
CG8299 31
  • 38 (a)
&egr;Try 31
  • 38 (a)
CG5197 31
  • 37 (a)
CG9294 31
  • 37 (a)
CG18065 31
  • 37 (a)
CG6041 31
  • 37 (a)
CG17239 31
  • 37 (a)
&lgr;Try 31
  • 37 (a)
CG17571 31
  • 37 (a)
&zgr;Try 31
  • 36 (a)
&eegr;Try 31
  • 35 (a)
CG16998 31
  • 35 (a)
CG10472 31
  • 34 (a)
CG7829 31
  • 34 (a)
&kgr;Try 31
  • 33 (a)
Species where no ortholog for PRSS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PRSS2 Gene

ENSEMBL:
Gene Tree for PRSS2 (if available)
TreeFam:
Gene Tree for PRSS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRSS2: view image
Alliance of Genome Resources:
Additional Orthologs for PRSS2

Paralogs for PRSS2 Gene

Paralogs for PRSS2 Gene

Pseudogenes.org Pseudogenes for PRSS2 Gene

genes like me logo Genes that share paralogs with PRSS2: view

Variants for PRSS2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS2 Gene

TRY2_HUMAN-P07478
His-153 variation is a common polymorphism in African populations with a minor allele frequency of 9.2%, it eliminates sulfation at Tyr-154, with no consequences on digestive physiology.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRSS2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs61734659 Protective: Pancreatitis, chronic, protection against 142,774,035(+) G/A
NM_002770.4(PRSS2):c.571G>A (p.Gly191Arg)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs11547028 -- p.Ala117Val
rs1804564 -- p.Asp153His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PRSS2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PRSS2 Gene

Variant ID Type Subtype PubMed ID
dgv11644n54 CNV loss 21841781
dgv11652n54 CNV loss 21841781
dgv1968e212 CNV gain 25503493
dgv1969e212 CNV loss 25503493
dgv841n27 CNV loss 19166990
esv2759569 CNV loss 17122850
esv34617 CNV loss 17911159
esv3576450 CNV gain 25503493
nsv1028035 CNV loss 25217958
nsv428187 CNV loss 18775914
nsv465148 CNV loss 19166990
nsv470396 CNV loss 18288195
nsv5982 CNV deletion 18451855
nsv818563 CNV loss 17921354
nsv824336 CNV loss 20364138
nsv831167 CNV gain+loss 17160897

Additional Variant Information for PRSS2 Gene

Human Gene Mutation Database (HGMD)
PRSS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS2
Leiden Open Variation Database (LOVD)
PRSS2

SNP Genotyping and Copy Number Assays for research

No data available for Variation tolerance for PRSS2 Gene

Disorders for PRSS2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for PRSS2 Gene - From: OMI, CVR, GTR, ORP, and GCD

Disorder Aliases PubMed IDs
pancreatitis, hereditary
  • pctt
pancreatitis
linitis plastica
  • leather-bottle stomach
tropical calcific pancreatitis
  • tcp
synovitis
- elite association - COSMIC cancer census association via MalaCards
Search PRSS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRSS2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PRSS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS2 Gene

Publications for PRSS2 Gene

  1. A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2). (PMID: 18986305) Rónai Z … Sahin-Tóth M (The Biochemical journal 2009) 3 4 22
  2. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. (PMID: 16699518) Witt H … Férec C (Nature genetics 2006) 3 40 72
  3. Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. (PMID: 3011602) Emi M … Matsubara K (Gene 1986) 2 3 4
  4. Identification of pancreatic juice proteins as biomarkers of pancreatic cancer. (PMID: 20428826) Gao J … Ma L (Oncology reports 2010) 3 22
  5. Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis. (PMID: 19077465) Sundaresan S … Drenth JP (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2009) 3 22

Products for PRSS2 Gene

Sources for PRSS2 Gene