This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcr... See more...

Aliases for PRSS16 Gene

Aliases for PRSS16 Gene

  • Serine Protease 16 2 3 4 5
  • Thymus-Specific Serine Protease 2 3 4
  • TSSP 2 3 4
  • Protease, Serine 16 2 3
  • Thymus Specific Serine Peptidase 3
  • Protease, Serine, 16 (Thymus) 3
  • EC 3.4.-.- 4
  • PRSS16 5

External Ids for PRSS16 Gene

Previous GeneCards Identifiers for PRSS16 Gene

  • GC06P027273
  • GC06P027323
  • GC06P027217
  • GC06P027023

Summaries for PRSS16 Gene

Entrez Gene Summary for PRSS16 Gene

  • This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRSS16 Gene

PRSS16 (Serine Protease 16) is a Protein Coding gene. Diseases associated with PRSS16 include Capillariasis and Sparganosis. Gene Ontology (GO) annotations related to this gene include serine-type peptidase activity. An important paralog of this gene is DPP7.

UniProtKB/Swiss-Prot Summary for PRSS16 Gene

Gene Wiki entry for PRSS16 Gene

Additional gene information for PRSS16 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRSS16 Gene

Genomics for PRSS16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRSS16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J027250 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +3.7 3700 2.4 ZNF221 SP1 CREB1 CTCF PRDM10 ZNF629 LEF1 IKZF1 KDM1A JUND PRSS16 ZSCAN9 BTN3A2 HCG11 BTN2A2 ZKSCAN8 RNU6-471P BTN2A1 H2AC12 NONHSAG043275.2
GH06J027247 Promoter 0.9 EPDnew 600.7 +0.0 11 0.1 LEF1 IKZF1 PKNOX1 MTA1 DPF2 HDAC1 SOX6 TCF12 EP300 CBX3 PRSS16 ZNF192P1 NONHSAG043275.2 LOC105375107
GH06J027161 Enhancer 0.9 ENCODE 5.9 -85.7 -85654 0.2 CTCF ZNF629 DDX20 ZNF24 MTA1 REST RAD21 ZNF501 TRIM22 ELF4 TRT-AGT6-1 ZNF322 ZKSCAN8 ENSG00000261584 ABT1 H2BC15 PRSS16 TRH-GTG1-5 H2AC12
GH06J027268 Promoter 0.6 Ensembl 7.5 +20.5 20500 0.4 CREB1 EZH2 ZBTB33 ENSG00000270935 LOC442172 POM121L2 RNU6-471P PRSS16 ZNF603P TRI-AAT9-1 LOC105375107
GH06J027154 Enhancer 0.6 Ensembl ENCODE 3.9 -92.5 -92500 1.6 ZNF512 ZBTB33 EGR1 EMSY MLLT1 piR-41405-041 H2BC13 BTN2A2 LINC00240 PRSS16 lnc-HIST1H2AH-3 H2AC12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRSS16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRSS16

Top Transcription factor binding sites by QIAGEN in the PRSS16 gene promoter:
  • AP-4
  • CUTL1
  • Egr-2
  • GATA-1
  • LUN-1
  • NRF-2
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT5A

Genomic Locations for PRSS16 Gene

Genomic Locations for PRSS16 Gene
chr6:27,247,701-27,256,624
(GRCh38/hg38)
Size:
8,924 bases
Orientation:
Plus strand
chr6:27,215,480-27,224,403
(GRCh37/hg19)
Size:
8,924 bases
Orientation:
Plus strand

Genomic View for PRSS16 Gene

Genes around PRSS16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS16 Gene

Proteins for PRSS16 Gene

  • Protein details for PRSS16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQE7-TSSP_HUMAN
    Recommended name:
    Thymus-specific serine protease
    Protein Accession:
    Q9NQE7
    Secondary Accessions:
    • O75416

    Protein attributes for PRSS16 Gene

    Size:
    514 amino acids
    Molecular mass:
    55049 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS16 Gene

Post-translational modifications for PRSS16 Gene

  • Glycosylation at Asn70, Asn172, and Asn321
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for PRSS16
  • Santa Cruz Biotechnology (SCBT) Antibodies for PRSS16

No data available for DME Specific Peptides for PRSS16 Gene

Domains & Families for PRSS16 Gene

Gene Families for PRSS16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PRSS16 Gene

InterPro:
Blocks:
  • Peptidase S28
ProtoNet:

Suggested Antigen Peptide Sequences for PRSS16 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52815, highly similar to Thymus-specific serine protease (EC 3.4.-.-) (B4DZV2_HUMAN)
  • Serine protease 16 (TSSP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NQE7

UniProtKB/Swiss-Prot:

TSSP_HUMAN :
  • Belongs to the peptidase S28 family.
Family:
  • Belongs to the peptidase S28 family.
genes like me logo Genes that share domains with PRSS16: view

Function for PRSS16 Gene

Molecular function for PRSS16 Gene

UniProtKB/Swiss-Prot Function:
Protease that may play a role in T-cell development.
GENATLAS Biochemistry:
protease serine 16,expressed in thymus,located in cortical thymic epithelial cells

Enzyme Numbers (IUBMB) for PRSS16 Gene

Phenotypes From GWAS Catalog for PRSS16 Gene

Gene Ontology (GO) - Molecular Function for PRSS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA,NAS 10527559
GO:0008239 dipeptidyl-peptidase activity IBA 21873635
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS16: view
genes like me logo Genes that share phenotypes with PRSS16: view

Animal Models for PRSS16 Gene

MGI Knock Outs for PRSS16:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS16

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS16

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRSS16 Gene

Localization for PRSS16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS16 Gene

Cytoplasmic vesicle. Note=Vesicular, either lysosomal or endosomal.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS16 gene
Compartment Confidence
endosome 5
lysosome 5
extracellular 3
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for PRSS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA,IDA 10527559
GO:0005768 endosome IEA,IDA 10527559
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with PRSS16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS16 Gene

Pathways & Interactions for PRSS16 Gene

PathCards logo

SuperPathways for PRSS16 Gene

No Data Available

Interacting Proteins for PRSS16 Gene

Gene Ontology (GO) - Biological Process for PRSS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IBA 21873635
GO:0030163 protein catabolic process NAS 10527559
genes like me logo Genes that share ontologies with PRSS16: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS16 Gene

Drugs & Compounds for PRSS16 Gene

No Compound Related Data Available

Transcripts for PRSS16 Gene

mRNA/cDNA for PRSS16 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRSS16

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS16 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b · 10c ^ 11a · 11b ^
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - - - - - - -
SP17: - - - - -
SP18: - -
SP19:
SP20: - - - - -
SP21: - - - - - -

ExUns: 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d · 14e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11: - -
SP12:
SP13: - -
SP14: - -
SP15:
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21: - -

Relevant External Links for PRSS16 Gene

GeneLoc Exon Structure for
PRSS16

Expression for PRSS16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRSS16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Thymus (Hematopoietic System)

mRNA differential expression in normal tissues according to GTEx for PRSS16 Gene

This gene is overexpressed in Pancreas (x10.6) and Thyroid (x4.3).

Protein differential expression in normal tissues from HIPED for PRSS16 Gene

This gene is overexpressed in Pancreatic juice (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS16 Gene



Protein tissue co-expression partners for PRSS16 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRSS16

SOURCE GeneReport for Unigene cluster for PRSS16 Gene:

Hs.274407

mRNA Expression by UniProt/SwissProt for PRSS16 Gene:

Q9NQE7-TSSP_HUMAN
Tissue specificity: Expressed predominantly in cortical thymic epithelial cells.

Evidence on tissue expression from TISSUES for PRSS16 Gene

  • Skin(2.1)
genes like me logo Genes that share expression patterns with PRSS16: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS16 Gene

Orthologs for PRSS16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRSS16 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRSS16 30 31
  • 99.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PRSS16 30 31
  • 83.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PRSS16 30 31
  • 82.82 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Prss16 30
  • 79.52 (n)
Mouse
(Mus musculus)
Mammalia Prss16 30 17 31
  • 79.23 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PRSS16 31
  • 61 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PRSS16 31
  • 35 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PRSS16 31
  • 41 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia prss16 30
  • 53.01 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9988 30
Zebrafish
(Danio rerio)
Actinopterygii LOC100334526 30
  • 48.31 (n)
prss16 31
  • 35 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG9953 32
  • 35 (a)
CG11626 31
  • 28 (a)
OneToMany
CG3734 31 32
  • 25 (a)
OneToMany
CG18493 31
  • 25 (a)
OneToMany
CG3739 31 32
  • 22 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea K12H4.7a 32
  • 32 (a)
K12H4.7b 32
  • 30 (a)
F28E10.5 31
  • 29 (a)
OneToMany
K12H4.7 31
  • 29 (a)
OneToMany
C26B9.5 31 32
  • 25 (a)
OneToMany
F56F10.1 31 32
  • 25 (a)
OneToMany
F19C7.2 31
  • 24 (a)
OneToMany
pcp-2 31
  • 13 (a)
OneToMany
pcp-4 31
  • 13 (a)
OneToMany
pcp-3 31
  • 12 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G36190 30
  • 43.03 (n)
Rice
(Oryza sativa)
Liliopsida Os10g0511400 30
  • 41.2 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8568 31
  • 31 (a)
OneToOne
Species where no ortholog for PRSS16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PRSS16 Gene

ENSEMBL:
Gene Tree for PRSS16 (if available)
TreeFam:
Gene Tree for PRSS16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRSS16: view image

Paralogs for PRSS16 Gene

Paralogs for PRSS16 Gene

(1) SIMAP similar genes for PRSS16 Gene using alignment to 8 proteins:

  • TSSP_HUMAN
  • B4DZV2_HUMAN
  • C9JDN6_HUMAN
  • F2Z2N5_HUMAN
  • F8WBG5_HUMAN
  • F8WF25_HUMAN
  • H0Y893_HUMAN
  • H0Y8B9_HUMAN
genes like me logo Genes that share paralogs with PRSS16: view

Variants for PRSS16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRSS16 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
770923 Benign: not provided 27,255,285(+) AAAGGAGAGCCAGATT INFRAME_DELETION
rs35466700 - p.Ala204Gly
rs5030965 - p.Ser104Ile

Additional dbSNP identifiers (rs#s) for PRSS16 Gene

Variation tolerance for PRSS16 Gene

Residual Variation Intolerance Score: 34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.45; 81.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRSS16 Gene

Human Gene Mutation Database (HGMD)
PRSS16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRSS16 Gene

Disorders for PRSS16 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRSS16 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
capillariasis
  • capillaria infection
sparganosis
  • infection by sparganum
diabetes mellitus, type i
  • diabetes mellitus, insulin-dependent; iddm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PRSS16

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PRSS16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS16 Gene

Publications for PRSS16 Gene

  1. Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus. (PMID: 10527559) Bowlus CL … Gruen JR (Cellular immunology 1999) 2 3 4 23
  2. Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases. (PMID: 12140752) Lie BA … Undlien DE (Genes and immunity 2002) 3 23 41
  3. Common variants conferring risk of schizophrenia. (PMID: 19571808) Stefansson H … Collier DA (Nature 2009) 3 41
  4. Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex. (PMID: 19295542) Viken MK … Lie BA (Genes and immunity 2009) 3 41
  5. Common variants on chromosome 6p22.1 are associated with schizophrenia. (PMID: 19571809) Shi J … Gejman PV (Nature 2009) 3 41

Products for PRSS16 Gene

  • Signalway ELISA kits for PRSS16

Sources for PRSS16 Gene