Aliases for PRSS12 Gene
External Ids for PRSS12 Gene
Previous GeneCards Identifiers for PRSS12 Gene
This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017]
GeneCards Summary for PRSS12 Gene
PRSS12 (Serine Protease 12) is a Protein Coding gene. Diseases associated with PRSS12 include Autosomal Recessive Non-Syndromic Intellectual Disability and Axenfeld-Rieger Syndrome. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is DMBT1.
UniProtKB/Swiss-Prot Summary for PRSS12 Gene
Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.