Aliases for PRSS1 Gene
External Ids for PRSS1 Gene
Previous HGNC Symbols for PRSS1 Gene
Previous GeneCards Identifiers for PRSS1 Gene
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRSS1 Gene
PRSS1 (Serine Protease 1) is a Protein Coding gene. Diseases associated with PRSS1 include Pancreatitis, Hereditary and Recurrent Acute Pancreatitis. Among its related pathways are Peptide ligand-binding receptors and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PRSS2.
UniProtKB/Swiss-Prot Summary for PRSS1 Gene
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.