Aliases for PRRX2 Gene
External Ids for PRRX2 Gene
Previous GeneCards Identifiers for PRRX2 Gene
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRRX2 Gene
PRRX2 (Paired Related Homeobox 2) is a Protein Coding gene. Diseases associated with PRRX2 include Hypoplastic Right Heart Syndrome and Agnathia-Otocephaly Complex. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is PRRX1.
UniProtKB/Swiss-Prot Summary for PRRX2 Gene
May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.