Free for academic non-profit institutions. Other users need a Commercial license
Aliases for PRRT4 Gene
Aliases for PRRT4 Gene
External Ids for PRRT4 Gene
- HGNC: 37280
- Entrez Gene: 401399
- Ensembl: ENSG00000224940
- UniProtKB: C9JH25
Previous GeneCards Identifiers for PRRT4 Gene
- GC07M127779
- GC07M127990
- GC07M122351
Summaries for PRRT4 Gene
GeneCards Summary for PRRT4 Gene
PRRT4 (Proline Rich Transmembrane Protein 4) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRRT4 Gene
Genomics for PRRT4 Gene
GeneHancer (GH) Regulatory Elements for PRRT4 Gene
Promoters and enhancers for PRRT4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRRT4 on UCSC Golden Path with GeneCards custom track
Genomic Locations for PRRT4 Gene
Genomic Locations for PRRT4 Gene
- chr7:128,350,325-128,362,069
- (GRCh38/hg38)
- Size:
- 11,745 bases
- Orientation:
- Minus strand
- chr7:127,990,379-128,001,739
- (GRCh37/hg19)
- Size:
- 11,361 bases
- Orientation:
- Minus strand
Genomic View for PRRT4 Gene
Genes around PRRT4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q32.1 by HGNC
- 7q32.1 by Entrez Gene
- 7q32.1 by Ensembl
PRRT4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRRT4 Gene
Proteins for PRRT4 Gene
-
Protein details for PRRT4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- C9JH25-PRRT4_HUMAN
- Recommended name:
- Proline-rich transmembrane protein 4
- Protein Accession:
- C9JH25
- A4D0Z9
- C9JVW7
Protein attributes for PRRT4 Gene
- Size:
- 899 amino acids
- Molecular mass:
- 92712 Da
- Quaternary structure:
- No Data Available
Protein Expression for PRRT4 Gene
Post-translational modifications for PRRT4 Gene
Other Protein References for PRRT4 Gene
Antibody Products
- Atlas Antibodies Anti-PRRT4 Antibody (HPA052681) and Anti-PRRT4 Antibody (HPA046373)
- Creative Diagnostics Anti-PRRT4 (aa 523-552) polyclonal antibody
- Novus Biologicals Antibodies for PRRT4
- Invitrogen Antibodies for PRRT4 (AFLGC-PRRT4)
- antibodies-online: Show 9 available PRRT4 Antibodies ranked by validation data
Protein Products
- Atlas Antibodies PrEST Antigen PRRT4 (APrEST87620) and PrEST Antigen PRRT4 (APrEST87468)
-
OriGene Purified Proteins for PRRT4
- Search Origene for MassSpec and Protein Over-expression Lysates for PRRT4
- Origene Custom Protein Services for PRRT4
- Novus Biologicals proteins for PRRT4
No data available for DME Specific Peptides for PRRT4 Gene
Domains & Families for PRRT4 Gene
Gene Families for PRRT4 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for PRRT4 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for PRRT4 Gene
- GenScript: Design optimal peptide antigens:
-
- Proline-rich transmembrane protein 4 (PRRT4_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRRT4 Gene
Function for PRRT4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for PRRT4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRRT4
- genomics-online: gRNA clones - Search for available PRRT4 gRNA products
- Overview of 80 available PRRT4 gene related products
- Applied Biological Materials (abm): CRISPR Clones for PRRT4 - Select products 50% OFF >
- * PRRT4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * PRRT4 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRRT4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PRRT4
- Browse OriGene Inhibitory RNA Products For PRRT4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRRT4
- genomics-online: shRNA clones - Search for available PRRT4 shRNA products
- Overview of 80 available PRRT4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PRRT4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRRT4
- genomics-online: cdna clones - Search for available PRRT4 CDNA products
- Overview of 80 available PRRT4 gene related products
- orf clones - Search for available PRRT4 ORF products
- Overview of 80 available PRRT4 gene related products
- Applied Biological Materials (abm): Clones for PRRT4 - Select products 50% OFF >
- * PRRT4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * PRRT4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for PRRT4
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRRT4 Gene
Localization for PRRT4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRRT4 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
- Nucleoplasm (2)
- Peroxisomes (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for PRRT4 Gene
Interacting Proteins for PRRT4 Gene
No data available for Pathways by source and SIGNOR curated interactions for PRRT4 Gene
Drugs & Compounds for PRRT4 Gene
No Compound Related Data Available
Drug Products
- Atlas Antibodies PrEST Antigen PRRT4 (APrEST87620) and PrEST Antigen PRRT4 (APrEST87468)
Transcripts for PRRT4 Gene
mRNA/cDNA for PRRT4 Gene
- (2) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (28) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000446477 3544 bps (ENST00000446477.6)
- ENST00000464607 883 bps (ENST00000464607.1)
- ENST00000480290 1789 bps (ENST00000480290.5)
- ENST00000489517 1887 bps (ENST00000489517.1)
- ENST00000489835 2313 bps (ENST00000489835.6)
CRISPR Products
-
OriGene CRISPR knockouts for PRRT4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRRT4
- genomics-online: gRNA clones - Search for available PRRT4 gRNA products
- Overview of 80 available PRRT4 gene related products
- Applied Biological Materials (abm): CRISPR Clones for PRRT4 - Select products 50% OFF >
- * PRRT4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * PRRT4 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRRT4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PRRT4
- Browse OriGene Inhibitory RNA Products For PRRT4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRRT4
- genomics-online: shRNA clones - Search for available PRRT4 shRNA products
- Overview of 80 available PRRT4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PRRT4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRRT4
- genomics-online: cdna clones - Search for available PRRT4 CDNA products
- Overview of 80 available PRRT4 gene related products
- orf clones - Search for available PRRT4 ORF products
- Overview of 80 available PRRT4 gene related products
- Applied Biological Materials (abm): Clones for PRRT4 - Select products 50% OFF >
- * PRRT4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * PRRT4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for PRRT4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
mRNA differential expression in normal tissues according to GTEx for PRRT4 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x9.1) and Adipose - Subcutaneous (x4.3).
This gene is overexpressed in Platelet (42.8) and Saliva (26.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRRT4 Gene
NURSA nuclear receptor signaling pathways regulating expression of PRRT4 Gene:
PRRT4SOURCE GeneReport for Unigene cluster for PRRT4 Gene:
Hs.381096Primer Products
-
OriGene qPCR primer pairs for PRRT4
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRRT4 Gene
Orthologs for PRRT4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PRRT4 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PRRT4 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PRRT4 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Prrt4 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Prrt4 17 33 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PRRT4 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PRRT4 33 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | PRRT4 33 |
|
OneToOne |
- Species where no ortholog for PRRT4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PRRT4 Gene
- ENSEMBL:
- Gene Tree for PRRT4 (if available)
- TreeFam:
- Gene Tree for PRRT4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRRT4: view image
Paralogs for PRRT4 Gene
No data available for Paralogs for PRRT4 Gene
Variants for PRRT4 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000192806 | -- | 128,363,879(-) | G/T | upstream_transcript_variant | |
| rs1000265279 | -- | 128,359,470(-) | G/A/T | coding_sequence_variant, missense_variant, synonymous_variant | |
| rs1000301275 | -- | 128,359,785(-) | G/A | coding_sequence_variant, synonymous_variant | |
| rs1000350498 | -- | 128,359,583(-) | C/T | coding_sequence_variant, missense_variant | |
| rs1000739643 | -- | 128,360,549(-) | G/C | 5_prime_UTR_variant, intron_variant |
Gene Damage Index Score:
11.23;
92.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRRT4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRRT4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRT4 Gene
Disorders for PRRT4 Gene
Additional Disease Information for PRRT4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PRRT4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRRT4 Gene
Publications for PRRT4 Gene
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
- Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 56
- Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 56
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
- Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 56
ExternalLinks
Products for PRRT4 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PRRT4
- Search Origene for MassSpec and Protein Over-expression Lysates for PRRT4
- Origene Custom Protein Services for PRRT4
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PRRT4
- Browse OriGene Inhibitory RNA Products For PRRT4
- OriGene qPCR primer pairs for PRRT4
- OriGene CRISPR knockouts for PRRT4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PRRT4
- Sino Biological Human cDNA Clone for PRRT4
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PRRT4
- Novus Biologicals proteins for PRRT4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for PRRT4 (AFLGC-PRRT4)
- antibodies-online: Show 9 available PRRT4 Antibodies ranked by validation data
- antibodies-online: Search results for available PRRT4 related products ranked by validation data
- antibodies-online: Search results for available PRRT4 related products ranked by validation data
- Horizon Cell Lines for PRRT4
- genomics-online: cdna clones - Search for available PRRT4 CDNA products
- Overview of 80 available PRRT4 gene related products
- orf clones - Search for available PRRT4 ORF products
- Overview of 80 available PRRT4 gene related products
- genomics-online: gRNA clones - Search for available PRRT4 gRNA products
- Overview of 80 available PRRT4 gene related products
- genomics-online: primer clones - Search for available PRRT4 Primer products
- Overview of 80 available PRRT4 gene related products
- genomics-online: shRNA clones - Search for available PRRT4 shRNA products
- Overview of 80 available PRRT4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRRT4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRRT4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PRRT4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRRT4
Sources for PRRT4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource