Aliases for PRRT4 Gene

Aliases for PRRT4 Gene

  • Proline Rich Transmembrane Protein 4 2 3 5
  • Proline-Rich Transmembrane Protein 4 2 3 4

External Ids for PRRT4 Gene

Previous GeneCards Identifiers for PRRT4 Gene

  • GC07M127779
  • GC07M127990
  • GC07M122351

Summaries for PRRT4 Gene

GeneCards Summary for PRRT4 Gene

PRRT4 (Proline Rich Transmembrane Protein 4) is a Protein Coding gene.

Additional gene information for PRRT4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRRT4 Gene

Genomics for PRRT4 Gene

GeneHancer (GH) Regulatory Elements for PRRT4 Gene

Promoters and enhancers for PRRT4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRRT4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRRT4 Gene

Genomic Locations for PRRT4 Gene
chr7:128,350,325-128,362,069
(GRCh38/hg38)
Size:
11,745 bases
Orientation:
Minus strand
chr7:127,990,379-128,001,739
(GRCh37/hg19)
Size:
11,361 bases
Orientation:
Minus strand

Genomic View for PRRT4 Gene

Genes around PRRT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRT4 Gene

Proteins for PRRT4 Gene

  • Protein details for PRRT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JH25-PRRT4_HUMAN
    Recommended name:
    Proline-rich transmembrane protein 4
    Protein Accession:
    C9JH25
    Secondary Accessions:
    • A4D0Z9
    • C9JVW7

    Protein attributes for PRRT4 Gene

    Size:
    899 amino acids
    Molecular mass:
    92712 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRRT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRRT4 Gene

Post-translational modifications for PRRT4 Gene

  • Glycosylation at Ser139, Thr143, and Ser206
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PRRT4 Gene

Domains & Families for PRRT4 Gene

Gene Families for PRRT4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for PRRT4 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PRRT4 Gene

GenScript: Design optimal peptide antigens:
  • Proline-rich transmembrane protein 4 (PRRT4_HUMAN)
genes like me logo Genes that share domains with PRRT4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRRT4 Gene

Function for PRRT4 Gene

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRRT4 Gene

Localization for PRRT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRRT4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRRT4 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Peroxisomes (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRRT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRRT4: view

Pathways & Interactions for PRRT4 Gene

PathCards logo

SuperPathways for PRRT4 Gene

No Data Available

Interacting Proteins for PRRT4 Gene

Selected Interacting proteins: C9JH25-PRRT4_HUMAN for PRRT4 Gene via IID

Symbol External ID(s) Details
NTRK1

Gene Ontology (GO) - Biological Process for PRRT4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRRT4 Gene

Drugs & Compounds for PRRT4 Gene

No Compound Related Data Available

Transcripts for PRRT4 Gene

mRNA/cDNA for PRRT4 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRRT4 Gene

No ASD Table

Relevant External Links for PRRT4 Gene

GeneLoc Exon Structure for
PRRT4
ECgene alternative splicing isoforms for
PRRT4

Expression for PRRT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRRT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRRT4 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x9.1) and Adipose - Subcutaneous (x4.3).

Protein differential expression in normal tissues from HIPED for PRRT4 Gene

This gene is overexpressed in Platelet (42.8) and Saliva (26.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRRT4 Gene



Protein tissue co-expression partners for PRRT4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRRT4 Gene:

PRRT4

SOURCE GeneReport for Unigene cluster for PRRT4 Gene:

Hs.381096
genes like me logo Genes that share expression patterns with PRRT4: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRRT4 Gene

Orthologs for PRRT4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRRT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRRT4 33 32
  • 99.41 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRRT4 33 32
  • 87.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRRT4 33 32
  • 86.97 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prrt4 32
  • 83 (n)
mouse
(Mus musculus)
Mammalia Prrt4 17 33 32
  • 82.89 (n)
oppossum
(Monodelphis domestica)
Mammalia PRRT4 33
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRRT4 33
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PRRT4 33
  • 25 (a)
OneToOne
Species where no ortholog for PRRT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRRT4 Gene

ENSEMBL:
Gene Tree for PRRT4 (if available)
TreeFam:
Gene Tree for PRRT4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRRT4: view image

Paralogs for PRRT4 Gene

No data available for Paralogs for PRRT4 Gene

Variants for PRRT4 Gene

Sequence variations from dbSNP and Humsavar for PRRT4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000192806 -- 128,363,879(-) G/T upstream_transcript_variant
rs1000265279 -- 128,359,470(-) G/A/T coding_sequence_variant, missense_variant, synonymous_variant
rs1000301275 -- 128,359,785(-) G/A coding_sequence_variant, synonymous_variant
rs1000350498 -- 128,359,583(-) C/T coding_sequence_variant, missense_variant
rs1000739643 -- 128,360,549(-) G/C 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRRT4 Gene

Variant ID Type Subtype PubMed ID
esv2493565 CNV deletion 19546169
nsv365384 CNV deletion 16902084
nsv608400 CNV loss 21841781
nsv831124 CNV gain+loss 17160897
nsv949939 CNV deletion 24416366

Variation tolerance for PRRT4 Gene

Gene Damage Index Score: 11.23; 92.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRRT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRRT4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRT4 Gene

Disorders for PRRT4 Gene

Additional Disease Information for PRRT4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PRRT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRRT4 Gene

Publications for PRRT4 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 56
  3. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 56

Products for PRRT4 Gene

Sources for PRRT4 Gene