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Aliases for PRRT3 Gene

Aliases for PRRT3 Gene

  • Proline Rich Transmembrane Protein 3 2 3 5
  • Proline-Rich Transmembrane Protein 3 2 3

External Ids for PRRT3 Gene

Previous GeneCards Identifiers for PRRT3 Gene

  • GC03M009963
  • GC03M009986
  • GC03M009923
  • GC03M009988
  • GC03M009989

Summaries for PRRT3 Gene

GeneCards Summary for PRRT3 Gene

PRRT3 (Proline Rich Transmembrane Protein 3) is a Protein Coding gene.

Additional gene information for PRRT3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRT3 Gene

Genomics for PRRT3 Gene

GeneHancer (GH) Regulatory Elements for PRRT3 Gene

Promoters and enhancers for PRRT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J009951 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.3 332 1.5 HDGF ARNT SIN3A ZNF2 ZNF213 E2F8 ZNF143 KLF13 ZNF263 SP3 PRRT3 BRPF1 SETD5 RAD18 THUMPD3-AS1 TTLL3 TATDN2 LINC00852 OGG1 EMC3-AS1
GH03J009953 Enhancer 0.4 FANTOM5 650.7 -1.6 -1638 0.4 ZNF362 PRDM10 PRRT3 ENSG00000269982 PRRT3-AS1
GH03J009985 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.5 -34.7 -34738 2.5 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 EMC3-AS1 EMC3 BRPF1 FANCD2 SETD5 BRK1 GHRLOS RNU6-670P FANCD2OS PRRT3
GH03J009889 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.4 +61.6 61576 2.4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B JAGN1 CIDEC BRPF1 RAD18 SETD5 FANCD2 LINC00852 TTLL3 GHRLOS SEC13
GH03J009730 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 +220.4 220360 3 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC BRPF1 SETD5 SRGAP3-AS3 THUMPD3-AS1 CYCSP10 SRGAP3-AS1 ENSG00000269886 RAD18 EMC3-AS1 ENSG00000269894
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRRT3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRRT3 gene promoter:

Genomic Locations for PRRT3 Gene

Genomic Locations for PRRT3 Gene
chr3:9,945,542-9,952,394
(GRCh38/hg38)
Size:
6,853 bases
Orientation:
Minus strand
chr3:9,987,226-9,994,078
(GRCh37/hg19)

Genomic View for PRRT3 Gene

Genes around PRRT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRT3 Gene

Proteins for PRRT3 Gene

  • Protein details for PRRT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5FWE3-PRRT3_HUMAN
    Recommended name:
    Proline-rich transmembrane protein 3
    Protein Accession:
    Q5FWE3
    Secondary Accessions:
    • Q49AD0
    • Q6UXY6
    • Q8NBC9

    Protein attributes for PRRT3 Gene

    Size:
    981 amino acids
    Molecular mass:
    102197 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRRT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRRT3 Gene

Post-translational modifications for PRRT3 Gene

  • Glycosylation at Asn379, Thr363, posLast=336336, posLast=329329, Thr324, and Thr210
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PRRT3_HUMAN (724)

Other Protein References for PRRT3 Gene

No data available for DME Specific Peptides for PRRT3 Gene

Domains & Families for PRRT3 Gene

Gene Families for PRRT3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for PRRT3 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PRRT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRRT3: view

No data available for UniProtKB/Swiss-Prot for PRRT3 Gene

Function for PRRT3 Gene

genes like me logo Genes that share phenotypes with PRRT3: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRRT3 Gene

Localization for PRRT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRRT3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRRT3 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRRT3: view

Pathways & Interactions for PRRT3 Gene

SuperPathways for PRRT3 Gene

No Data Available

Interacting Proteins for PRRT3 Gene

Selected Interacting proteins: Q5FWE3-PRRT3_HUMAN for PRRT3 Gene via IID

Symbol External ID(s) Details
TMEM17

Gene Ontology (GO) - Biological Process for PRRT3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRRT3 Gene

Drugs & Compounds for PRRT3 Gene

No Compound Related Data Available

Transcripts for PRRT3 Gene

mRNA/cDNA for PRRT3 Gene

Unigene Clusters for PRRT3 Gene

Proline-rich transmembrane protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRRT3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2: -
SP3:

Relevant External Links for PRRT3 Gene

GeneLoc Exon Structure for
PRRT3
ECgene alternative splicing isoforms for
PRRT3

Expression for PRRT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRRT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRRT3 Gene

This gene is overexpressed in Cerebrospinal fluid (19.0), Serum (18.5), Heart (11.5), Frontal cortex (8.4), and Liver (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRRT3 Gene



NURSA nuclear receptor signaling pathways regulating expression of PRRT3 Gene:

PRRT3

SOURCE GeneReport for Unigene cluster for PRRT3 Gene:

Hs.598147

Evidence on tissue expression from TISSUES for PRRT3 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with PRRT3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRRT3 Gene

Orthologs for PRRT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRRT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRRT3 34 33
  • 99.12 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRRT3 34 33
  • 84.17 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRRT3 34 33
  • 82.7 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prrt3 33
  • 77.73 (n)
mouse
(Mus musculus)
Mammalia Prrt3 16 34 33
  • 77.08 (n)
oppossum
(Monodelphis domestica)
Mammalia PRRT3 34
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRRT3 34
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PRRT3 34
  • 25 (a)
OneToOne
Species where no ortholog for PRRT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRRT3 Gene

ENSEMBL:
Gene Tree for PRRT3 (if available)
TreeFam:
Gene Tree for PRRT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRRT3: view image

Paralogs for PRRT3 Gene

No data available for Paralogs for PRRT3 Gene

Variants for PRRT3 Gene

Sequence variations from dbSNP and Humsavar for PRRT3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000684092 -- 9,945,168(-) A/G downstream_transcript_variant
rs1001222286 -- 9,945,613(-) T/G 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1001307028 -- 9,952,814(-) G/A upstream_transcript_variant
rs1002762606 -- 9,945,492(-) C/T downstream_transcript_variant
rs1002876658 -- 9,946,198(-) G/A/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRRT3 Gene

Variant ID Type Subtype PubMed ID
nsv589648 CNV loss 21841781
nsv834615 CNV loss 17160897

Variation tolerance for PRRT3 Gene

Residual Variation Intolerance Score: 25.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.17; 93.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRRT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRRT3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRT3 Gene

Disorders for PRRT3 Gene

Additional Disease Information for PRRT3

No disorders were found for PRRT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRRT3 Gene

Publications for PRRT3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58

Products for PRRT3 Gene

Sources for PRRT3 Gene

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