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Aliases for PRRG3 Gene

Aliases for PRRG3 Gene

  • Proline Rich And Gla Domain 3 2 3 5
  • Proline Rich Gla (G-Carboxyglutamic Acid) 3 (Transmembrane) 2 3
  • Proline-Rich Gamma-Carboxyglutamic Acid Protein 3 3 4
  • Proline-Rich Gla Protein 3 3 4
  • PRGP3 3 4
  • TMG3 3 4
  • Transmembrane Gamma-Carboxyglutamic Acid Protein 3 3

External Ids for PRRG3 Gene

Previous GeneCards Identifiers for PRRG3 Gene

  • GC0XP150537
  • GC0XP150863
  • GC0XP139720

Summaries for PRRG3 Gene

Entrez Gene Summary for PRRG3 Gene

  • This gene encodes a protein which contains a vitamin K-dependent carboxylation/gamma-carboxyglutamic domain. The encoded protein is a member of a family of vitamin K-dependent transmembrane proteins which contain a glutamate-rich extracellular domain. [provided by RefSeq, Aug 2011]

GeneCards Summary for PRRG3 Gene

PRRG3 (Proline Rich And Gla Domain 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PRRG1.

Additional gene information for PRRG3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRG3 Gene

Genomics for PRRG3 Gene

GeneHancer (GH) Regulatory Elements for PRRG3 Gene

Promoters and enhancers for PRRG3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI151694 Promoter 1.1 EPDnew Ensembl 550.8 +0.4 425 0.6 EZH2 PRRG3 FATE1
GH0XI151696 Enhancer 0.2 ENCODE 550.8 +0.8 809 0 PRRG3 FATE1
GH0XI151695 Enhancer 0.5 ENCODE 30.2 +2.2 2207 2.6 RFX1 ZNF366 ZNF512 FOS BMI1 PRRG3 FATE1
GH0XI151702 Enhancer 0.2 ENCODE 9.9 +9.2 9163 3.1 PRRG3 FATE1
GH0XI151715 Promoter 0.5 EPDnew 0.3 +21.3 21264 0.1 FATE1 PRRG3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRRG3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRRG3 gene promoter:

Genomic Locations for PRRG3 Gene

Genomic Locations for PRRG3 Gene
11,249 bases
Plus strand

Genomic View for PRRG3 Gene

Genes around PRRG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRG3 Gene

Proteins for PRRG3 Gene

  • Protein details for PRRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane gamma-carboxyglutamic acid protein 3
    Protein Accession:
    Secondary Accessions:
    • A1A523
    • A1A575
    • Q8N2N6

    Protein attributes for PRRG3 Gene

    231 amino acids
    Molecular mass:
    25875 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRRG3 Gene

Post-translational modifications for PRRG3 Gene

  • Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRRG3 Gene

No data available for DME Specific Peptides for PRRG3 Gene

Domains & Families for PRRG3 Gene

Gene Families for PRRG3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PRRG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRRG3: view

No data available for UniProtKB/Swiss-Prot for PRRG3 Gene

Function for PRRG3 Gene

Gene Ontology (GO) - Molecular Function for PRRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PRRG3: view
genes like me logo Genes that share phenotypes with PRRG3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRRG3 Gene

Localization for PRRG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRRG3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRRG3 gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11171957
genes like me logo Genes that share ontologies with PRRG3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRRG3 Gene

Pathways & Interactions for PRRG3 Gene

SuperPathways for PRRG3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PRRG3: view

No data available for Pathways by source and SIGNOR curated interactions for PRRG3 Gene

Drugs & Compounds for PRRG3 Gene

No Compound Related Data Available

Transcripts for PRRG3 Gene

Unigene Clusters for PRRG3 Gene

Proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRRG3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: -
SP2: - -

Relevant External Links for PRRG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRRG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRRG3 Gene

mRNA differential expression in normal tissues according to GTEx for PRRG3 Gene

This gene is overexpressed in Nerve - Tibial (x5.7), Brain - Frontal Cortex (BA9) (x4.6), Brain - Cortex (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Protein differential expression in normal tissues from HIPED for PRRG3 Gene

This gene is overexpressed in Heart (54.7) and Testis (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRRG3 Gene

Protein tissue co-expression partners for PRRG3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRRG3 Gene:


SOURCE GeneReport for Unigene cluster for PRRG3 Gene:


mRNA Expression by UniProt/SwissProt for PRRG3 Gene:

Tissue specificity: Expressed in brain, lung, kidney and heart.

Evidence on tissue expression from TISSUES for PRRG3 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PRRG3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRRG3 Gene

Orthologs for PRRG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRRG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRRG3 33 34
  • 99.13 (n)
(Bos Taurus)
Mammalia PRRG3 33 34
  • 90.62 (n)
(Canis familiaris)
Mammalia PRRG3 33 34
  • 89.75 (n)
(Rattus norvegicus)
Mammalia Prrg3 33
  • 87.88 (n)
(Mus musculus)
Mammalia Prrg3 33 16 34
  • 87.3 (n)
(Ornithorhynchus anatinus)
Mammalia PRRG3 34
  • 65 (a)
(Gallus gallus)
Aves PRRG3 33 34
  • 75.92 (n)
(Anolis carolinensis)
Reptilia PRRG3 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prrg3 33
  • 65.37 (n)
(Danio rerio)
Actinopterygii LOC563290 33
  • 60.85 (n)
PRRG3 34
  • 49 (a)
Species where no ortholog for PRRG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRRG3 Gene

Gene Tree for PRRG3 (if available)
Gene Tree for PRRG3 (if available)

Paralogs for PRRG3 Gene

Paralogs for PRRG3 Gene

(12) SIMAP similar genes for PRRG3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRRG3: view

Variants for PRRG3 Gene

Sequence variations from dbSNP and Humsavar for PRRG3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000043866 -- 151,694,804(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000197478 -- 151,698,163(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000448446 -- 151,695,786(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000526477 -- 151,699,765(+) T/C intron_variant
rs1001159363 -- 151,697,695(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRRG3 Gene

Variant ID Type Subtype PubMed ID
nsv7156 CNV insertion 18451855

Variation tolerance for PRRG3 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRRG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRG3 Gene

Disorders for PRRG3 Gene

Additional Disease Information for PRRG3

No disorders were found for PRRG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRRG3 Gene

Publications for PRRG3 Gene

  1. Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. (PMID: 11171957) Kulman JD … Davie EW (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 58

Products for PRRG3 Gene

Sources for PRRG3 Gene

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