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Aliases for PRRG2 Gene

Aliases for PRRG2 Gene

  • Proline Rich And Gla Domain 2 2 3 5
  • Proline-Rich Gla (G-Carboxyglutamic Acid) Polypeptide 2 2 3
  • Proline-Rich Gamma-Carboxyglutamic Acid Protein 2 3 4
  • Proline-Rich Gla Protein 2 3 4
  • PRGP2 3 4
  • Proline-Rich Gla (G-Carboxglutamic Acid) Polypeptide 2 3
  • Transmembrane Gamma-Carboxyglutamic Acid Protein 2 3
  • Proline Rich Gla (G-Carboxyglutamic Acid) 2 3
  • TMG2 4

External Ids for PRRG2 Gene

Previous GeneCards Identifiers for PRRG2 Gene

  • GC19P050744
  • GC19P050454
  • GC19P054759
  • GC19P054778
  • GC19P050084
  • GC19P046464

Summaries for PRRG2 Gene

Entrez Gene Summary for PRRG2 Gene

  • The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for PRRG2 Gene

PRRG2 (Proline Rich And Gla Domain 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PRRG4.

Additional gene information for PRRG2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRG2 Gene

Genomics for PRRG2 Gene

GeneHancer (GH) Regulatory Elements for PRRG2 Gene

Promoters and enhancers for PRRG2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049579 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 670.1 +0.2 173 2.4 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 PRRG2 NOSIP PRR12 NUP62 POLD1 SNORD35A SNORD35B IRF3 PIH1D1 ALDH16A1
GH19J049589 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 20.7 +11.4 11426 5.8 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 PRR12 NOSIP PIR34329 NUP62 POLD1 IRF3 ENSG00000268047 ALDH16A1 SNORD35A SNORD35B
GH19J049567 Enhancer 1.4 Ensembl ENCODE dbSUPER 18.9 -11.1 -11051 4.6 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF121 PRR12 NOSIP SNORD35B PRRG2 POLD1 NUP62 PTOV1-AS2 SNORD35A FCGRT MIR150
GH19J049511 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.6 -66.3 -66261 5.7 HDGF PKNOX1 MLX ARID4B SIN3A ZNF48 TCF12 ZNF121 GLIS2 RUNX3 FCGRT PRR12 RCN3 SNORD32A SNORD33 SNORD34 SNORD35A RPL13A PRRG2 NOSIP
GH19J049552 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.2 -25.3 -25267 5.7 PKNOX1 FOXA2 ARID4B ZNF143 MIXL1 EGR2 ZNF362 ZNF623 NR2F2 PCBP2 NOSIP PRR12 SNORD35A SNORD35B RPS11 RPL13A FCGRT ALDH16A1 POLD1 RCN3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRRG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRRG2 gene promoter:
  • Egr-2
  • c-Myb
  • FOXO1a
  • FOXO1
  • p53
  • RFX1
  • STAT5A
  • HOXA3
  • Elk-1
  • c-Myc

Genomic Locations for PRRG2 Gene

Genomic Locations for PRRG2 Gene
10,399 bases
Plus strand
10,370 bases
Plus strand

Genomic View for PRRG2 Gene

Genes around PRRG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRG2 Gene

Proteins for PRRG2 Gene

  • Protein details for PRRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane gamma-carboxyglutamic acid protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6IBF8

    Protein attributes for PRRG2 Gene

    202 amino acids
    Molecular mass:
    22393 Da
    Quaternary structure:
    • Interacts with NEDD4.

neXtProt entry for PRRG2 Gene

Post-translational modifications for PRRG2 Gene

  • Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRRG2 Gene

No data available for DME Specific Peptides for PRRG2 Gene

Domains & Families for PRRG2 Gene

Gene Families for PRRG2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PRRG2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRRG2: view

No data available for UniProtKB/Swiss-Prot for PRRG2 Gene

Function for PRRG2 Gene

Phenotypes From GWAS Catalog for PRRG2 Gene

Gene Ontology (GO) - Molecular Function for PRRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IBA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 17502622
genes like me logo Genes that share ontologies with PRRG2: view
genes like me logo Genes that share phenotypes with PRRG2: view

Animal Models for PRRG2 Gene

MGI Knock Outs for PRRG2:
  • Prrg2 Prrg2<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for PRRG2

CRISPR Products

miRNA for PRRG2 Gene

miRTarBase miRNAs that target PRRG2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRRG2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRRG2 Gene

Localization for PRRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRRG2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRRG2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 NOT extracellular space IBA --
GO:0005887 integral component of plasma membrane TAS 9256434
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRRG2: view

Pathways & Interactions for PRRG2 Gene

SuperPathways for PRRG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PRRG2: view

No data available for Pathways by source and SIGNOR curated interactions for PRRG2 Gene

Drugs & Compounds for PRRG2 Gene

No Compound Related Data Available

Transcripts for PRRG2 Gene

mRNA/cDNA for PRRG2 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRRG2 Gene

Proline rich Gla (G-carboxyglutamic acid) 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRRG2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRRG2 Gene

No ASD Table

Relevant External Links for PRRG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRRG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRRG2 Gene

mRNA differential expression in normal tissues according to GTEx for PRRG2 Gene

This gene is overexpressed in Pituitary (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of PRRG2 Gene:


SOURCE GeneReport for Unigene cluster for PRRG2 Gene:


mRNA Expression by UniProt/SwissProt for PRRG2 Gene:

Tissue specificity: Highly expressed in the thyroid.
genes like me logo Genes that share expression patterns with PRRG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRRG2 Gene

Orthologs for PRRG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRRG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRRG2 34 33
  • 97.69 (n)
(Canis familiaris)
Mammalia PRRG2 34 33
  • 87.29 (n)
(Bos Taurus)
Mammalia PRRG2 34 33
  • 82.74 (n)
(Mus musculus)
Mammalia Prrg2 16 34 33
  • 80.76 (n)
(Rattus norvegicus)
Mammalia Prrg2 33
  • 79.08 (n)
(Monodelphis domestica)
Mammalia PRRG2 34
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia PRRG2 34
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prrg4 33
  • 51.59 (n)
(Danio rerio)
Actinopterygii prrg2 34 33
  • 51.9 (n)
Species where no ortholog for PRRG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRRG2 Gene

Gene Tree for PRRG2 (if available)
Gene Tree for PRRG2 (if available)
Evolutionary constrained regions (ECRs) for PRRG2: view image

Paralogs for PRRG2 Gene

Paralogs for PRRG2 Gene

(9) SIMAP similar genes for PRRG2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRRG2: view

Variants for PRRG2 Gene

Sequence variations from dbSNP and Humsavar for PRRG2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000082702 -- 49,590,226(+) G/A intron_variant
rs1000261389 -- 49,586,299(+) G/A intron_variant
rs1000332089 -- 49,580,610(+) C/T upstream_transcript_variant
rs1000861328 -- 49,589,281(+) C/T intron_variant
rs1000883726 -- 49,578,734(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRRG2 Gene

Variant ID Type Subtype PubMed ID
nsv1071938 CNV deletion 25765185
nsv1118832 CNV deletion 24896259
nsv1160655 CNV deletion 26073780
nsv469715 CNV gain+loss 16826518
nsv828578 CNV loss 20364138
nsv833863 CNV loss 17160897
nsv833864 CNV gain 17160897
nsv833865 CNV gain+loss 17160897
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for PRRG2 Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRRG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRG2 Gene

Disorders for PRRG2 Gene

Additional Disease Information for PRRG2

No disorders were found for PRRG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRRG2 Gene

Publications for PRRG2 Gene

  1. Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins. (PMID: 9256434) Kulman JD … Davie EW (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 58
  2. Proline-rich Gla protein 2 is a cell-surface vitamin K-dependent protein that binds to the transcriptional coactivator Yes-associated protein. (PMID: 17502622) Kulman JD … Davie EW (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 22 58
  3. Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. (PMID: 11171957) Kulman JD … Davie EW (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 22 58
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58

Products for PRRG2 Gene

Sources for PRRG2 Gene

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