Aliases for PRRG2 Gene
External Ids for PRRG2 Gene
Previous GeneCards Identifiers for PRRG2 Gene
The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
GeneCards Summary for PRRG2 Gene
PRRG2 (Proline Rich And Gla Domain 2) is a Protein Coding gene. Diseases associated with PRRG2 include Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is MASP2.