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Aliases for PRRG1 Gene

Aliases for PRRG1 Gene

  • Proline Rich And Gla Domain 1 2 3 5
  • Proline-Rich Gla (G-Carboxyglutamic Acid) Polypeptide 1 2 3
  • PRGP1 3 4
  • Transmembrane Gamma-Carboxyglutamic Acid Protein 1 3
  • Proline-Rich Gamma-Carboxyglutamic Acid Protein 1 4
  • Proline Rich Gla (G-Carboxyglutamic Acid) 1 3
  • Proline-Rich Gla Protein 1 4
  • TMG1 4

External Ids for PRRG1 Gene

Previous GeneCards Identifiers for PRRG1 Gene

  • GC0XP035313
  • GC0XP035496
  • GC0XP036053
  • GC0XP036239
  • GC0XP036964
  • GC0XP037093
  • GC0XP037209
  • GC0XP034955

Summaries for PRRG1 Gene

Entrez Gene Summary for PRRG1 Gene

  • This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for PRRG1 Gene

PRRG1 (Proline Rich And Gla Domain 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PRRG3.

Additional gene information for PRRG1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRG1 Gene

Genomics for PRRG1 Gene

GeneHancer (GH) Regulatory Elements for PRRG1 Gene

Promoters and enhancers for PRRG1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI037346 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.6 -612 4.7 HDAC1 KLF17 SIN3A ZNF2 YY1 ZNF335 EGR1 ZNF366 EGR2 ZNF362 ENSG00000250349 PRRG1 MOB1AP2
GH0XI036963 Promoter/Enhancer 1.1 FANTOM5 Ensembl 3.3 -385.6 -385641 0.7 RXRA MAX REST RAD21 YY1 HNF4G HNF4A EZH2 LOC441488 PRRG1 LOC100422408
GH0XI037381 Enhancer 1 Ensembl ENCODE 0.3 +31.8 31834 0.2 FEZF1 RFX5 TCF12 ZNF366 ZSCAN5C FOS USF2 CEBPB ZEB2 ZNF843 ENSG00000250349 PRRG1 LOC100420326
GH0XI037314 Enhancer 0.6 Ensembl ENCODE 0.3 -32.7 -32670 3.9 STAT1 JUN ZNF384 MOB1AP2 PRRG1
GH0XI037320 Enhancer 0.4 ENCODE 0.3 -28.3 -28292 0.2 POLR2A HLF MOB1AP2 PRRG1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRRG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRRG1 gene promoter:

Genomic Locations for PRRG1 Gene

Genomic Locations for PRRG1 Gene
108,021 bases
Plus strand

Genomic View for PRRG1 Gene

Genes around PRRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRG1 Gene

Proteins for PRRG1 Gene

  • Protein details for PRRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane gamma-carboxyglutamic acid protein 1
    Protein Accession:
    Secondary Accessions:
    • B2R7A3
    • C9JXL7
    • D3DWA9
    • Q5JT66

    Protein attributes for PRRG1 Gene

    218 amino acids
    Molecular mass:
    24947 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRRG1 Gene


neXtProt entry for PRRG1 Gene

Post-translational modifications for PRRG1 Gene

  • Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.
  • Ubiquitination at isoforms=210 and isoforms=66
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PRRG1 Gene

Domains & Families for PRRG1 Gene

Gene Families for PRRG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for PRRG1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRRG1: view

No data available for UniProtKB/Swiss-Prot for PRRG1 Gene

Function for PRRG1 Gene

Gene Ontology (GO) - Molecular Function for PRRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PRRG1: view
genes like me logo Genes that share phenotypes with PRRG1: view

Animal Model Products

CRISPR Products

miRNA for PRRG1 Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRRG1 Gene

Localization for PRRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRRG1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRRG1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005887 integral component of plasma membrane TAS 9256434
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRRG1: view

Pathways & Interactions for PRRG1 Gene

SuperPathways for PRRG1 Gene

No Data Available

Interacting Proteins for PRRG1 Gene

Selected Interacting proteins: O14668-TMG1_HUMAN for PRRG1 Gene via IID

Gene Ontology (GO) - Biological Process for PRRG1 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRRG1 Gene

Drugs & Compounds for PRRG1 Gene

No Compound Related Data Available

Transcripts for PRRG1 Gene

Unigene Clusters for PRRG1 Gene

Proline rich Gla (G-carboxyglutamic acid) 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRRG1 Gene

No ASD Table

Relevant External Links for PRRG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRRG1 Gene

mRNA differential expression in normal tissues according to GTEx for PRRG1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.5) and Brain - Substantia nigra (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of PRRG1 Gene:


SOURCE GeneReport for Unigene cluster for PRRG1 Gene:


mRNA Expression by UniProt/SwissProt for PRRG1 Gene:

Tissue specificity: Highly expressed in the spinal cord.

Evidence on tissue expression from TISSUES for PRRG1 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with PRRG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRRG1 Gene

Orthologs for PRRG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRRG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRRG1 34
  • 100 (a)
(Canis familiaris)
Mammalia LOC491821 33
  • 92.81 (n)
PRRG1 34
  • 92 (a)
(Mus musculus)
Mammalia Prrg1 33 16 34
  • 90.37 (n)
(Bos Taurus)
Mammalia PRRG1 33 34
  • 89.91 (n)
(Rattus norvegicus)
Mammalia Prrg1 33
  • 89.04 (n)
(Monodelphis domestica)
Mammalia PRRG1 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia PRRG1 34
  • 67 (a)
(Gallus gallus)
Aves PRRG1 33 34
  • 70.37 (n)
(Anolis carolinensis)
Reptilia PRRG1 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prrg1 33
  • 64.38 (n)
Str.6489 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398382 33
(Danio rerio)
Actinopterygii zgc:103657 33
  • 47.38 (n)
PRRG1 34
  • 38 (a)
Species where no ortholog for PRRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRRG1 Gene

Gene Tree for PRRG1 (if available)
Gene Tree for PRRG1 (if available)

Paralogs for PRRG1 Gene

Paralogs for PRRG1 Gene

(9) SIMAP similar genes for PRRG1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRRG1: view

Variants for PRRG1 Gene

Sequence variations from dbSNP and Humsavar for PRRG1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
VAR_036268 A breast cancer sample p.Phe60Ile
rs1000061244 -- 37,445,462(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000148804 -- 37,406,246(+) A/G 5_prime_UTR_variant
rs1000175688 -- 37,444,907(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000297137 -- 37,455,356(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRRG1 Gene

Variant ID Type Subtype PubMed ID
esv3576845 CNV gain 25503493
nsv1115858 CNV duplication 24896259
nsv1119334 CNV duplication 24896259
nsv1148646 CNV duplication 26484159
nsv6863 CNV insertion 18451855

Variation tolerance for PRRG1 Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRG1 Gene

Disorders for PRRG1 Gene

Additional Disease Information for PRRG1

No disorders were found for PRRG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRRG1 Gene

Publications for PRRG1 Gene

  1. Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins. (PMID: 9256434) Kulman JD … Davie EW (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PMID: 23940030) Teixeira FR … Gomes MD (The Journal of biological chemistry 2013) 3 58
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen JV … Mann M (Science signaling 2010) 4 58

Products for PRRG1 Gene

Sources for PRRG1 Gene

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