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Aliases for PRRC2B Gene

Aliases for PRRC2B Gene

  • Proline Rich Coiled-Coil 2B 2 3 5
  • KIAA0515 2 3 4
  • HLA-B-Associated Transcript 2-Like 1 3 4
  • Proline-Rich Coiled-Coil Protein 2B 3 4
  • HLA-B Associated Transcript 2-Like 2 3
  • BAT2L1 3 4
  • BAT2L 3 4
  • HLA-B Associated Transcript 2-Like 1 2
  • Proline-Rich Coiled-Coil 2B 2
  • Protein BAT2-Like 1 3
  • Protein PRRC2B 3
  • LQFBS-1 3

External Ids for PRRC2B Gene

Previous HGNC Symbols for PRRC2B Gene

  • KIAA0515
  • BAT2L
  • BAT2L1

Previous GeneCards Identifiers for PRRC2B Gene

  • GC09P134271

Summaries for PRRC2B Gene

GeneCards Summary for PRRC2B Gene

PRRC2B (Proline Rich Coiled-Coil 2B) is a Protein Coding gene. An important paralog of this gene is PRRC2C.

Gene Wiki entry for PRRC2B Gene

Additional gene information for PRRC2B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRC2B Gene

Genomics for PRRC2B Gene

GeneHancer (GH) Regulatory Elements for PRRC2B Gene

Promoters and enhancers for PRRC2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J131392 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 656.6 +22.2 22155 6.7 CLOCK ARNT SIN3A DMAP1 YY1 ZNF213 ZNF143 FOS KLF13 SP3 PRRC2B POMT1 NUP214 SETX EXOSC2 ENSG00000236986 UCK1 GC09M131403 PIR32430 GC09P131226
GH09J131372 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 652.1 -0.2 -235 2.4 HDGF PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 PRRC2B SETX NUP214 EXOSC2 LOC105376301 ENSG00000236986 POMT1 AIF1L ENSG00000285287 GC09P131226
GH09J131417 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 657.2 +44.9 44904 3 FOXA2 SIN3A FEZF1 BATF GLIS2 ZNF366 RUNX3 EGR2 ZNF362 CEBPB PRRC2B POMT1 ENSG00000176868 PIR53214 PIR32430 GC09M131403 GC09P131226
GH09J132240 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 31.3 +867.7 867734 2.7 HDGF CLOCK SMAD1 GLI4 ZNF2 ZNF121 GLIS2 ZNF202 SP3 YY2 GTF3C4 DDX31 GTF3C5 PRRC2B TSC1 SETX POMT1 TTF1 NTNG2 GC09M132284
GH09J131502 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18 +129.6 129571 1.9 HDGF CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B POMT1 GC09M131500 SETX EXOSC2 ENSG00000246851 PRRC2B TTF1 NUP214 LOC105376301
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRRC2B on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRRC2B Gene

Genomic Locations for PRRC2B Gene
chr9:131,373,636-131,500,197
(GRCh38/hg38)
Size:
126,562 bases
Orientation:
Plus strand
chr9:134,269,480-134,375,584
(GRCh37/hg19)
Size:
106,105 bases
Orientation:
Plus strand

Genomic View for PRRC2B Gene

Genes around PRRC2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRC2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRC2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRC2B Gene

Proteins for PRRC2B Gene

  • Protein details for PRRC2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JSZ5-PRC2B_HUMAN
    Recommended name:
    Protein PRRC2B
    Protein Accession:
    Q5JSZ5
    Secondary Accessions:
    • O60270
    • Q5JSZ7
    • Q66VZ2
    • Q68CR0
    • Q96EI9
    • Q9H683

    Protein attributes for PRRC2B Gene

    Size:
    2229 amino acids
    Molecular mass:
    242967 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH18678.1; Type=Erroneous termination; Positions=637; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRRC2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRRC2B Gene

Post-translational modifications for PRRC2B Gene

  • Ubiquitination at posLast=15101510
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for PRRC2B
  • Boster Bio Antibodies for PRRC2B
  • Santa Cruz Biotechnology (SCBT) Antibodies for PRRC2B

No data available for DME Specific Peptides for PRRC2B Gene

Domains & Families for PRRC2B Gene

Gene Families for PRRC2B Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PRRC2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRRC2B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRRC2B: view

No data available for UniProtKB/Swiss-Prot for PRRC2B Gene

Function for PRRC2B Gene

Phenotypes From GWAS Catalog for PRRC2B Gene

Gene Ontology (GO) - Molecular Function for PRRC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with PRRC2B: view
genes like me logo Genes that share phenotypes with PRRC2B: view

Animal Models for PRRC2B Gene

MGI Knock Outs for PRRC2B:
  • Prrc2b Prrc2b<tm1a(EUCOMM)Wtsi>

Animal Model Products

miRNA for PRRC2B Gene

miRTarBase miRNAs that target PRRC2B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRRC2B Gene

Localization for PRRC2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRRC2B gene
Compartment Confidence
nucleus 3
cytosol 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRRC2B Gene

Pathways & Interactions for PRRC2B Gene

SuperPathways for PRRC2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRRC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with PRRC2B: view

No data available for Pathways by source and SIGNOR curated interactions for PRRC2B Gene

Drugs & Compounds for PRRC2B Gene

No Compound Related Data Available

Transcripts for PRRC2B Gene

mRNA/cDNA for PRRC2B Gene

Unigene Clusters for PRRC2B Gene

Proline-rich coiled-coil 2B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRRC2B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ·
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:

ExUns: 20c ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c · 23d · 23e
SP1: -
SP2: -
SP3: -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - -
SP13: -
SP14: -

Relevant External Links for PRRC2B Gene

GeneLoc Exon Structure for
PRRC2B
ECgene alternative splicing isoforms for
PRRC2B

Expression for PRRC2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRRC2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRRC2B Gene

This gene is overexpressed in Cerebrospinal fluid (22.1), Adrenal (11.0), Stomach (8.5), and Pancreatic juice (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRRC2B Gene



NURSA nuclear receptor signaling pathways regulating expression of PRRC2B Gene:

PRRC2B

SOURCE GeneReport for Unigene cluster for PRRC2B Gene:

Hs.743955

Evidence on tissue expression from TISSUES for PRRC2B Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with PRRC2B: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRRC2B Gene

Orthologs for PRRC2B Gene

This gene was present in the common ancestor of animals.

Orthologs for PRRC2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRRC2B 34 33
  • 99.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRRC2B 34 33
  • 87.77 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prrc2b 33
  • 85.59 (n)
mouse
(Mus musculus)
Mammalia Prrc2b 16 34 33
  • 85.57 (n)
cow
(Bos Taurus)
Mammalia PRRC2B 34 33
  • 85.36 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRRC2B 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRRC2B 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRRC2B 34 33
  • 75.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 81 (a)
OneToMany
-- 34
  • 59 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia prrc2b 33
  • 67 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC561451 33
  • 58.7 (n)
PRRC2B 34
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F52G3.1 34
  • 20 (a)
OneToMany
Species where no ortholog for PRRC2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRRC2B Gene

ENSEMBL:
Gene Tree for PRRC2B (if available)
TreeFam:
Gene Tree for PRRC2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRRC2B: view image

Paralogs for PRRC2B Gene

Paralogs for PRRC2B Gene

(1) SIMAP similar genes for PRRC2B Gene using alignment to 5 proteins:

  • PRC2B_HUMAN
  • H0Y412_HUMAN
  • H3BLU0_HUMAN
  • Q5JSZ9_HUMAN
  • Q5JT00_HUMAN
genes like me logo Genes that share paralogs with PRRC2B: view

Variants for PRRC2B Gene

Sequence variations from dbSNP and Humsavar for PRRC2B Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000129410 -- 131,439,671(+) T/A intron_variant
rs1000184818 -- 131,478,450(+) C/G intron_variant
rs1000229625 -- 131,480,517(+) T/G intron_variant
rs1000238293 -- 131,475,140(+) A/C coding_sequence_variant, missense_variant
rs1000282267 -- 131,445,267(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRRC2B Gene

Variant ID Type Subtype PubMed ID
dgv1512e214 CNV gain 21293372
esv2759718 CNV gain 17122850
esv34928 CNV gain 17911159
esv3621887 CNV loss 21293372
nsv1045498 CNV loss 25217958
nsv1161910 CNV duplication 26073780
nsv509327 CNV insertion 20534489
nsv517936 CNV loss 19592680
nsv615537 CNV loss 21841781
nsv615563 CNV loss 21841781
nsv6737 CNV insertion 18451855
nsv818728 CNV gain 17921354
nsv831740 CNV loss 17160897
nsv831741 CNV loss 17160897
nsv831742 CNV loss 17160897

Variation tolerance for PRRC2B Gene

Residual Variation Intolerance Score: 2.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.94; 83.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRRC2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRRC2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRC2B Gene

Disorders for PRRC2B Gene

Additional Disease Information for PRRC2B

No disorders were found for PRRC2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRRC2B Gene

Publications for PRRC2B Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PRRC2B Gene

Sources for PRRC2B Gene

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