Aliases for PRR7 Gene

Aliases for PRR7 Gene

  • Proline Rich 7, Synaptic 2 3 5
  • Synaptic Proline-Rich Membrane Protein 3 4
  • Proline-Rich Protein 7 3 4
  • Proline Rich 7 (Synaptic) 2

External Ids for PRR7 Gene

Previous GeneCards Identifiers for PRR7 Gene

  • GC05P176807
  • GC05P176873
  • GC05P171794

Summaries for PRR7 Gene

GeneCards Summary for PRR7 Gene

PRR7 (Proline Rich 7, Synaptic) is a Protein Coding gene. An important paralog of this gene is WBP1.

UniProtKB/Swiss-Prot Summary for PRR7 Gene

  • Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might promote apoptosis in T cells (PubMed:21460222).

Additional gene information for PRR7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRR7 Gene

Genomics for PRR7 Gene

GeneHancer (GH) Regulatory Elements for PRR7 Gene

Promoters and enhancers for PRR7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRR7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRR7 gene promoter:
  • AhR
  • Arnt
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B

Genomic Locations for PRR7 Gene

Genomic Locations for PRR7 Gene
chr5:177,446,344-177,456,701
(GRCh38/hg38)
Size:
10,358 bases
Orientation:
Plus strand
chr5:176,873,446-176,883,287
(GRCh37/hg19)
Size:
9,842 bases
Orientation:
Plus strand

Genomic View for PRR7 Gene

Genes around PRR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR7 Gene

Proteins for PRR7 Gene

  • Protein details for PRR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB68-PRR7_HUMAN
    Recommended name:
    Proline-rich protein 7
    Protein Accession:
    Q8TB68
    Secondary Accessions:
    • Q8WU53
    • Q9BTA7

    Protein attributes for PRR7 Gene

    Size:
    274 amino acids
    Molecular mass:
    30930 Da
    Quaternary structure:
    • Forms a complex with NMDA receptor zeta subunit GRIN1 and epsilon subunit GRIN2B (PubMed:27458189). Interacts with GRIN1 and GRIN2B (PubMed:27458189). The interaction with GRIN1 is reduced upon NMDA receptor activity (By similarity). Found in a postsynaptic membrane complex with DLG4 and GRIN1 (By similarity). Interacts with DLG4 (via PDZ3 domain and to lesser degree via PDZ2 domain) (By similarity). Found in a complex with JUN and FBXW7 (PubMed:27458189). Interacts with JUN and FBXW7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity (PubMed:27458189). Interacts with SRC (PubMed:21460222).

    Alternative splice isoforms for PRR7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRR7 Gene

Post-translational modifications for PRR7 Gene

No data available for DME Specific Peptides for PRR7 Gene

Domains & Families for PRR7 Gene

Gene Families for PRR7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR7 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PRR7 Gene

GenScript: Design optimal peptide antigens:
  • Synaptic proline-rich membrane protein (PRR7_HUMAN)
genes like me logo Genes that share domains with PRR7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRR7 Gene

Function for PRR7 Gene

Molecular function for PRR7 Gene

UniProtKB/Swiss-Prot Function:
Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might promote apoptosis in T cells (PubMed:21460222).
UniProtKB/Swiss-Prot Induction:
Up-regulated in peripheral blood leukocytes in response to T-cell receptor stimulation.

Phenotypes From GWAS Catalog for PRR7 Gene

Gene Ontology (GO) - Molecular Function for PRR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27458189
GO:0036041 long-chain fatty acid binding IMP 21460222
GO:0044389 ubiquitin-like protein ligase binding IPI 27458189
GO:0044877 protein-containing complex binding IEA --
GO:1990782 protein tyrosine kinase binding IPI 21460222
genes like me logo Genes that share ontologies with PRR7: view
genes like me logo Genes that share phenotypes with PRR7: view

Animal Models for PRR7 Gene

MGI Knock Outs for PRR7:
  • Prr7 Prr7<tm1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for PRR7 Gene

miRTarBase miRNAs that target PRR7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRR7 Gene

Localization for PRR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRR7 Gene

Cell membrane; Single-pass type III membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass type III membrane protein. Cytoplasm, perinuclear region. Cell junction, synapse. Cell projection, dendrite. Nucleus. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern. Translocates from synapses to nuclei following NMDA receptor activity (By similarity). {ECO:0000250 UniProtKB:P0C6T3}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR7 gene
Compartment Confidence
plasma membrane 4
nucleus 4
extracellular 3
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IMP 21460222
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PRR7: view

Pathways & Interactions for PRR7 Gene

PathCards logo

SuperPathways for PRR7 Gene

No Data Available

Interacting Proteins for PRR7 Gene

Selected Interacting proteins: Q8TB68-PRR7_HUMAN for PRR7 Gene via IID

Gene Ontology (GO) - Biological Process for PRR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0010942 positive regulation of cell death IMP 27458189
GO:0030217 T cell differentiation IEA --
GO:0031397 negative regulation of protein ubiquitination IMP 27458189
genes like me logo Genes that share ontologies with PRR7: view

No data available for Pathways by source and SIGNOR curated interactions for PRR7 Gene

Drugs & Compounds for PRR7 Gene

No Compound Related Data Available

Transcripts for PRR7 Gene

mRNA/cDNA for PRR7 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for PRR7 Gene

GeneLoc Exon Structure for
PRR7
ECgene alternative splicing isoforms for
PRR7

Expression for PRR7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRR7 Gene

mRNA differential expression in normal tissues according to GTEx for PRR7 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.4) and Brain - Nucleus accumbens (basal ganglia) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of PRR7 Gene:

PRR7

SOURCE GeneReport for Unigene cluster for PRR7 Gene:

Hs.534492

mRNA Expression by UniProt/SwissProt for PRR7 Gene:

Q8TB68-PRR7_HUMAN
Tissue specificity: Strongly expressed in brain tissue including the hippocampus, and moderately expressed in esophagus, trachea, lung, ovary, cervix, prostate, testes, thyroid, thymus, lymph nodes and peripheral blood lymphocytes.

Evidence on tissue expression from TISSUES for PRR7 Gene

  • Skin(4.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with PRR7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR7 Gene

Orthologs for PRR7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR7 33 32
  • 95.71 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prr7 32
  • 89.34 (n)
mouse
(Mus musculus)
Mammalia Prr7 17 33 32
  • 88.97 (n)
cow
(Bos Taurus)
Mammalia PRR7 33 32
  • 88.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRR7 33 32
  • 87.01 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRR7 33
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRR7 33
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX927237.2 33
  • 44 (a)
OneToOne
Species where no ortholog for PRR7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRR7 Gene

ENSEMBL:
Gene Tree for PRR7 (if available)
TreeFam:
Gene Tree for PRR7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRR7: view image

Paralogs for PRR7 Gene

Paralogs for PRR7 Gene

genes like me logo Genes that share paralogs with PRR7: view

Variants for PRR7 Gene

Sequence variations from dbSNP and Humsavar for PRR7 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000411522 -- 177,446,552(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000698031 -- 177,447,773(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000986634 -- 177,454,742(+) C/A 5_prime_UTR_variant, intron_variant
rs1001025642 -- 177,447,663(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001563063 -- 177,448,026(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRR7 Gene

Variant ID Type Subtype PubMed ID
dgv10184n54 CNV loss 21841781
dgv733n27 CNV loss 19166990
esv2677804 CNV deletion 23128226
esv2731192 CNV deletion 23290073
esv2731193 CNV deletion 23290073
esv2822 CNV loss 18987735
esv999663 CNV deletion 20482838
nsv1119054 CNV deletion 24896259
nsv1161311 CNV duplication 26073780
nsv1161313 CNV duplication 26073780
nsv329248 CNV deletion 16902084
nsv471057 CNV loss 18288195
nsv515805 CNV loss 19592680

Additional Variant Information for PRR7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PRR7 Gene

Disorders for PRR7 Gene

Additional Disease Information for PRR7

No disorders were found for PRR7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR7 Gene

Publications for PRR7 Gene

  1. Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity. (PMID: 27458189) Kravchick DO … Jordan BA (The EMBO journal 2016) 3 4 56
  2. PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis. (PMID: 21460222) Hrdinka M … Drbal K (The Journal of biological chemistry 2011) 3 4 56
  3. Proteomic analysis revealed a novel synaptic proline-rich membrane protein (PRR7) associated with PSD-95 and NMDA receptor. (PMID: 15629447) Murata Y … Fujiyoshi Y (Biochemical and biophysical research communications 2005) 2 3 56
  4. Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. (PMID: 22703881) Tang W … Folsom AR (American journal of human genetics 2012) 3 56
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 56

Products for PRR7 Gene

Sources for PRR7 Gene