Aliases for PRR5L Gene
External Ids for PRR5L Gene
Previous GeneCards Identifiers for PRR5L Gene
GeneCards Summary for PRR5L Gene
PRR5L (Proline Rich 5 Like) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling and mTOR signalling. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is PRR5.
UniProtKB/Swiss-Prot Summary for PRR5L Gene
Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062).