Aliases for PRR5L Gene
Aliases for PRR5L Gene
External Ids for PRR5L Gene
- HGNC: 25878
- Entrez Gene: 79899
- Ensembl: ENSG00000135362
- OMIM: 611728
- UniProtKB: Q6MZQ0
Previous GeneCards Identifiers for PRR5L Gene
- GC11P036017
Summaries for PRR5L Gene
GeneCards Summary for PRR5L Gene
PRR5L (Proline Rich 5 Like) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling and mTOR signalling. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is PRR5.
UniProtKB/Swiss-Prot for PRR5L Gene
-
Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062).
Additional gene information for PRR5L Gene
- Monarch Initiative
- Search for PRR5L at DataMed
- Search for PRR5L at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR5L Gene
Genomics for PRR5L Gene
GeneHancer (GH) Regulatory Elements for PRR5L Gene
Promoters and enhancers for PRR5L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRR5L on UCSC Golden Path with GeneCards custom track
Genomic Locations for PRR5L Gene
Genomic Locations for PRR5L Gene
- chr11:36,296,175-36,465,204
- (GRCh38/hg38)
- Size:
- 169,030 bases
- Orientation:
- Plus strand
- chr11:36,317,725-36,486,754
- (GRCh37/hg19)
- Size:
- 169,030 bases
- Orientation:
- Plus strand
Genomic View for PRR5L Gene
Genes around PRR5L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p13-p12 by HGNC
- 11p13-p12 by Entrez Gene
- 11p13 by Ensembl
PRR5L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRR5L Gene
Proteins for PRR5L Gene
-
Protein details for PRR5L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6MZQ0-PRR5L_HUMAN
- Recommended name:
- Proline-rich protein 5-like
- Protein Accession:
- Q6MZQ0
- A4QN22
- E9PKY1
- Q96H46
- Q9H7V4
Protein attributes for PRR5L Gene
- Size:
- 368 amino acids
- Molecular mass:
- 40836 Da
- Quaternary structure:
-
- Interacts with the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (PubMed:17461779). Interacts with RFFL (PubMed:22609986). Interacts (via C-terminus) with ZFP36 (via C-terminus); this interaction may accelerate ZFP36-mediated mRNA decay during stress (PubMed:21964062). Interacts with RICTOR (PubMed:21964062).
- SequenceCaution:
-
- Sequence=AAI25123.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Post-translational modifications for PRR5L Gene
- Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PRR5L Gene
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-
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-
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-
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Protein Products
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- Compare Top PRR5L Proteins
-
Quality Products:
No data available for DME Specific Peptides for PRR5L Gene
Domains & Families for PRR5L Gene
Gene Families for PRR5L Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PRR5L Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PRR5L Gene
- GenScript: Design optimal peptide antigens:
-
- Protein observed with Rictor-2 (PRR5L_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6MZQ0- Family:
-
- Belongs to the PROTOR family.
Function for PRR5L Gene
Molecular function for PRR5L Gene
- UniProtKB/Swiss-Prot Function:
- Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062).
Phenotypes From GWAS Catalog for PRR5L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21964062 |
| GO:0031625 | ubiquitin protein ligase binding | IPI | 22609986 |
Phenotypes for PRR5L Gene
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-
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miRNA for PRR5L Gene
- miRTarBase miRNAs that target PRR5L
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Cell Line Products
-
Horizon Cell Lines for PRR5L
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR5L Gene
Localization for PRR5L Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 3 |
| cytosol | 2 |
| nucleus | 1 |
- Cytokinetic bridge (2)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0031932 | TORC2 complex | IDA,IBA | 22609986 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRR5L Gene
Pathways & Interactions for PRR5L Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PI3K / Akt Signaling | ||
| 2 | mTOR signalling | ||
Pathways by source for PRR5L Gene
1 BioSystems pathway for PRR5L Gene
1 Cell Signaling Technology pathway for PRR5L Gene
Interacting Proteins for PRR5L Gene
GPS-Prot Interaction Network for PRR5L
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001933 | negative regulation of protein phosphorylation | IMP | 22609986 |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
| GO:0009968 | negative regulation of signal transduction | IEA | -- |
| GO:0010762 | regulation of fibroblast migration | IMP | 22609986 |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | IEA | -- |
No data available for SIGNOR curated interactions for PRR5L Gene
Transcripts for PRR5L Gene
mRNA/cDNA for PRR5L Gene
- (4) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (62) Selected AceView cDNA sequences:
- (20) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000531269 436 bps (uc058akv.1)
- ENST00000529034 562 bps (uc058akw.1)
- ENST00000530639 2291 bps (uc001mwo.5)
- ENST00000527172 544 bps (uc058akx.1)
- ENST00000532121 572 bps (uc058akz.1)
Unigene Clusters for PRR5L Gene
- Proline rich 5 like:
- Representative Sequences:
CRISPR Products
-
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- Overview of 104 available PRR5L gene related products
Clone Products
-
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Expression for PRR5L Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- S-shaped Body Cells S-shaped Body
- S-shaped Body
-
Blood (Hematopoietic System)
- pre Conventional Dendritic Cells Peripheral Blood
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Epithelial Cells
- Basal Cells Trachea
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
mRNA differential expression in normal tissues according to GTEx for PRR5L Gene
This gene is overexpressed in Colon - Transverse (x7.1), Spleen (x6.2), and Brain - Spinal cord (cervical c-1) (x5.4).
NURSA nuclear receptor signaling pathways regulating expression of PRR5L Gene:
PRR5LSOURCE GeneReport for Unigene cluster for PRR5L Gene:
Hs.19987Evidence on tissue expression from TISSUES for PRR5L Gene
- Nervous system(4.7)
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-
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Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR5L Gene
Orthologs for PRR5L Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PRR5L 35 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PRR5L 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Prr5l 17 35 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Prr5l 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PRR5L 35 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PRR5L 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PRR5L 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PRR5L 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PRR5L 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | prr5l 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC557634 34 |
|
||
| PRR5L 35 |
|
OneToOne |
- Species where no ortholog for PRR5L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PRR5L Gene
- ENSEMBL:
- Gene Tree for PRR5L (if available)
- TreeFam:
- Gene Tree for PRR5L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRR5L: view image
Paralogs for PRR5L Gene
Variants for PRR5L Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000024820 | -- | 36,427,670(+) | C/T | intron_variant | |
| rs1000026773 | -- | 36,387,930(+) | G/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000033104 | -- | 36,341,600(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000047848 | -- | 36,410,881(+) | G/C | intron_variant | |
| rs1000065678 | -- | 36,347,372(+) | C/A | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv341e212 | CNV | loss | 25503493 |
| esv2422305 | CNV | duplication | 17116639 |
| esv2475332 | CNV | insertion | 19546169 |
| esv2761662 | CNV | loss | 21179565 |
| esv27622 | CNV | loss | 19812545 |
| esv2762906 | CNV | loss | 21179565 |
| esv32890 | CNV | gain | 17666407 |
| esv32924 | CNV | loss | 17666407 |
| esv3304080 | CNV | mobile element insertion | 20981092 |
| esv3309539 | CNV | mobile element insertion | 20981092 |
| esv33552 | CNV | gain | 17666407 |
| esv3385094 | OTHER | inversion | 20981092 |
| esv3414530 | CNV | duplication | 20981092 |
| esv3421257 | CNV | duplication | 20981092 |
| esv3425565 | CNV | insertion | 20981092 |
| esv3578616 | CNV | gain | 25503493 |
| esv3692 | OTHER | inversion | 18987735 |
| esv8636 | CNV | gain | 19470904 |
| esv9649 | OTHER | inversion | 19470904 |
| nsv1042014 | CNV | loss | 25217958 |
| nsv1046452 | CNV | gain | 25217958 |
| nsv1111054 | CNV | tandem duplication | 24896259 |
| nsv1119419 | CNV | insertion | 24896259 |
| nsv1140474 | CNV | tandem duplication | 24896259 |
| nsv1145515 | CNV | deletion | 24896259 |
| nsv467791 | CNV | gain | 19166990 |
| nsv518499 | CNV | loss | 19592680 |
| nsv526434 | CNV | loss | 19592680 |
| nsv554003 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.05;
68.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRR5L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRR5L
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR5L Gene
Disorders for PRR5L Gene
Additional Disease Information for PRR5L
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PRR5L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR5L Gene
Publications for PRR5L Gene
- Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PMID: 17461779) Pearce LR … Alessi DR (The Biochemical journal 2007) 2 3 4 58
- Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. (PMID: 21964062) Holmes B … Gera J (Cellular signalling 2012) 3 4 58
- PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. (PMID: 22609986) Gan X … Wu D (Nature cell biology 2012) 3 4 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for PRR5L Gene
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- RC228136L2
- RC228136L3
- RC228136L4
- RC228171
- RC228171L1
- RC228171L2
- RC228171L3
- RC228171L4
- RC228296
- RC228296L1
- RC228296L2
- RC228296L3
- RC228296L4
- RG223241
- RG228136
- RG228171
- RG228296
- RR215491
- RR215491L1
- RR215491L2
- RR215491L3
- RR215491L4
- MR205410L1V
- MR205410L2V
- MR205410L3V
- MR205410L4V
- MR222021L1V
- MR222021L2V
- MR222021L3V
- MR222021L4V
- RC223241L1V
- RC223241L2V
- RC223241L3V
- RC223241L4V
- RC228136L1V
- RC228136L2V
- RC228136L3V
- RC228136L4V
- RC228171L1V
- RC228171L2V
- RC228171L3V
- RC228171L4V
- RC228296L1V
- RC228296L2V
- RC228296L3V
- RC228296L4V
- RR215491L1V
- RR215491L2V
- RR215491L3V
- RR215491L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Invitrogen Antibodies for PRR5L (AFLGC-PRR5L)
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- antibodies-online: Search results for 15 available PRR5L Antibodies ranked by validation data
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- Horizon Cell Lines for PRR5L
- genomics-online: cdna clones - Search results for 104 available PRR5L gene related products
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Sources for PRR5L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) HGMD
- (45) GAD
- (46) BGMUT
- (47) HuGE
- (48) Atlas
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) OCA
- (69) Proteopedia
- (70) MOPED
- (71) neXtProt
- (72) Reactome
- (73) GeneGo (Thomson Reuters)
- (74) fRNAdb
- (75) DISEASES
- (76) SIMAP
- (77) GenomeRNAi
- (78) LifeMap
- (79) miRTarBase
- (80) MalaCards
- (81) Invitrogen
- (82) BitterDB
- (83) ESI-BIO
- (84) RefSeq
- (85) BioSystems
- (86) MaxQB
- (87) IUPHAR
- (88) BioGPS
- (89) Illumina
- (90) COMPARTMENTS
- (91) HOMER
- (92) PaxDb
- (93) ApexBio
- (94) Addgene
- (95) antibodies-online
- (96) CYP
- (97) NONCODE
- (98) SwitchGear Genomics
- (99) TreeFam
- (100) PathCards
- (101) GeneReviews
- (102) GeneTex
- (103) Taconic Biosciences
- (104) GTEx
- (105) ProteomicsDB
- (106) SCBT
- (107) DGIdb
- (108) ClinicalTrials
- (109) FDA Approved Drugs
- (110) RVIS
- (111) SIGNOR
- (112) diseasecard
- (113) NIH Rare Diseases
- (114) Orphanet
- (115) UMLS
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- (117) Disease Ontology
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- (123) NCBI Bookshelf
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- (130) FANTOM5
- (131) ENCODE
- (132) ProSci
- (133) Horizon
- (134) NURSA
- (135) IID
- (136) Cyagen
- (137) VectorBuilder
- (138) SNPedia
- (139) BRCA Exchange
- (140) St John's Lab
- (141) CIViC
- (142) ProteoGenix
- (143) dbSUPER
- (144) TISSUES
- (145) Gene ORGANizer
- (146) abm
- (147) CrownBio
- (148) Human Protein Atlas
- (149) GWAS Catalog
- (150) Monarch Initiative
- (151) DataMed
- (152) HumanCyc
- (153) genomics-online
- (154) UCNEbase
- (155) EPDnew
- (156) Applied Biosystems
- (157) GlyConnect
- (158) Aminode
- (159) GeneCopoeia
- (160) GPS-Prot
- (161) RNACentral
- (162) LncRNADisease
- (163) LOVD
- (164) miR2Disease
- (165) DiseaseEnhancer
- (166) Boster Bio
- (167) Biorbyt
- (168) Biocompare