This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and P... See more...

Aliases for PRR5 Gene

Aliases for PRR5 Gene

  • Proline Rich 5 2 3 5
  • Protein Observed With Rictor-1 2 3 4
  • Proline-Rich Protein 5 3 4
  • Proline Rich 5 (Renal) 2 3
  • PROTOR1 3 4
  • Rho GTPase Activating Protein 8 3
  • FLJ20185k 3
  • PROTOR-1 3
  • Protor-1 4
  • PP610 3

External Ids for PRR5 Gene

Previous GeneCards Identifiers for PRR5 Gene

  • GC22U900291
  • GC22P043443
  • GC22P045064
  • GC22P028021

Summaries for PRR5 Gene

Entrez Gene Summary for PRR5 Gene

  • This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for PRR5 Gene

PRR5 (Proline Rich 5) is a Protein Coding gene. Among its related pathways are PI3K/AKT activation and CD28 co-stimulation. An important paralog of this gene is PRR5L.

UniProtKB/Swiss-Prot Summary for PRR5 Gene

  • Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.

Additional gene information for PRR5 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRR5 Gene

Genomics for PRR5 Gene

GeneHancer (GH) Regulatory Elements for PRR5 Gene

Promoters and enhancers for PRR5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J044697 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 761.7 +32.2 32204 6.5 CTCF RBPJ MYC CC2D1A ZNF701 MAX ZNF121 RAD21 NKRF ELF3 PRR5 PRR5-ARHGAP8 ENSG00000273243
GH22J044667 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 0.0 -46 3.4 CTCF GLIS2 PRDM10 PATZ1 GATAD2B ZBTB20 ZBTB10 FOXM1 ZFP69B ZNF335 PRR5 lnc-RTL6-2-001 lnc-RTL6-2-002 ARHGAP8 NUP50
GH22J044714 Promoter/Enhancer 0.9 EPDnew dbSUPER 750.2 +45.8 45813 0.1 ZNF652 SP1 RXRA YY1 HNF4A MAX HNF4G REST BK010224 PRR5 piR-32214-457 PRR5-ARHGAP8
GH22J044732 Promoter 0.4 EPDnew 750.2 +63.8 63827 0.1 HIC1 piR-52616 PRR5 RF00017-3868 PRR5-ARHGAP8
GH22J044757 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.8 +90.3 90347 2.6 ZSCAN21 GLIS2 ZIC2 ZBTB8A PRDM10 ZEB2 ZNF629 PATZ1 ZNF692 ZBTB20 PRR5-ARHGAP8 PRR5 ARHGAP8 piR-61861-018
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRR5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRR5 gene promoter:
  • E47
  • HEN1
  • NF-kappaB
  • NF-kappaB1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for PRR5 Gene

Genomic Locations for PRR5 Gene
chr22:44,668,547-44,737,681
(GRCh38/hg38)
Size:
69,135 bases
Orientation:
Plus strand
chr22:45,064,427-45,133,561
(GRCh37/hg19)
Size:
69,135 bases
Orientation:
Plus strand

Genomic View for PRR5 Gene

Genes around PRR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR5 Gene

Proteins for PRR5 Gene

  • Protein details for PRR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P85299-PRR5_HUMAN
    Recommended name:
    Proline-rich protein 5
    Protein Accession:
    P85299
    Secondary Accessions:
    • B1AHF6
    • B1AHG5
    • B3KP73
    • O75983
    • O95695
    • Q5BIW2
    • Q5EAJ8
    • Q5EAJ9
    • Q5XKJ6
    • Q96RW1
    • Q96RW2
    • Q9HA49
    • Q9HC46
    • Q9NSG0
    • Q9NVX8
    • Q9NXL1
    • Q9UH20

    Protein attributes for PRR5 Gene

    Size:
    388 amino acids
    Molecular mass:
    42753 Da
    Quaternary structure:
    • Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and RICTOR within the TORC2 complex.

    Alternative splice isoforms for PRR5 Gene

neXtProt entry for PRR5 Gene

Post-translational modifications for PRR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRR5 Gene

Domains & Families for PRR5 Gene

Gene Families for PRR5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR5 Gene

Suggested Antigen Peptide Sequences for PRR5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77560, highly similar to Homo sapiens proline rich protein 5 (PRR5), transcript variant 1, mRNA (A8K699_HUMAN)
  • Proline rich 5 (Renal) (B1AHF4_HUMAN)
  • Proline rich 5 (Renal) (B1AHG2_HUMAN)
  • Protein observed with Rictor-1 (PRR5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P85299

UniProtKB/Swiss-Prot:

PRR5_HUMAN :
  • Belongs to the PROTOR family.
Family:
  • Belongs to the PROTOR family.
genes like me logo Genes that share domains with PRR5: view

Function for PRR5 Gene

Molecular function for PRR5 Gene

UniProtKB/Swiss-Prot Function:
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.

Phenotypes From GWAS Catalog for PRR5 Gene

Gene Ontology (GO) - Molecular Function for PRR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24550280
genes like me logo Genes that share ontologies with PRR5: view
genes like me logo Genes that share phenotypes with PRR5: view

Animal Model Products

CRISPR Products

miRNA for PRR5 Gene

miRTarBase miRNAs that target PRR5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR5 Gene

Localization for PRR5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR5 gene
Compartment Confidence
cytosol 4

Gene Ontology (GO) - Cellular Components for PRR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0031932 TORC2 complex IDA 22609986
genes like me logo Genes that share ontologies with PRR5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PRR5 Gene

Pathways & Interactions for PRR5 Gene

genes like me logo Genes that share pathways with PRR5: view

Pathways by source for PRR5 Gene

Gene Ontology (GO) - Biological Process for PRR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA --
GO:0032148 activation of protein kinase B activity TAS --
GO:0038203 TORC2 signaling IBA 21873635
genes like me logo Genes that share ontologies with PRR5: view

No data available for SIGNOR curated interactions for PRR5 Gene

Drugs & Compounds for PRR5 Gene

No Compound Related Data Available

Transcripts for PRR5 Gene

mRNA/cDNA for PRR5 Gene

(6) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(18) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b ^ 15a ·
SP1: -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - -
SP8: - - - - - - - - - - - - - -
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:

Relevant External Links for PRR5 Gene

GeneLoc Exon Structure for
PRR5
ECgene alternative splicing isoforms for
PRR5

Expression for PRR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRR5 Gene

This gene is overexpressed in Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for PRR5 Gene

This gene is overexpressed in Placenta (44.8), CD8 Tcells (13.0), and Fetal testis (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRR5 Gene



Protein tissue co-expression partners for PRR5 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRR5 Gene:

PRR5

SOURCE GeneReport for Unigene cluster for PRR5 Gene:

Hs.102336

mRNA Expression by UniProt/SwissProt for PRR5 Gene:

P85299-PRR5_HUMAN
Tissue specificity: Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors.

Evidence on tissue expression from TISSUES for PRR5 Gene

  • Intestine(4.3)
  • Kidney(4.2)
  • Liver(4.1)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with PRR5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR5 Gene

Orthologs for PRR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR5 33 32
  • 99.43 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRR5 33 32
  • 89.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRR5 33 32
  • 88.83 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prr5 32
  • 85.38 (n)
mouse
(Mus musculus)
Mammalia Prr5 17 33 32
  • 84.86 (n)
chicken
(Gallus gallus)
Aves PRR5 33 32
  • 72.06 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRR5 33
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii prr5 33 32
  • 64.55 (n)
OneToOne
Species where no ortholog for PRR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRR5 Gene

ENSEMBL:
Gene Tree for PRR5 (if available)
TreeFam:
Gene Tree for PRR5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRR5: view image

Paralogs for PRR5 Gene

Paralogs for PRR5 Gene

(3) SIMAP similar genes for PRR5 Gene using alignment to 8 proteins:

  • PRR5_HUMAN
  • B1AHF5_HUMAN
  • B1AHG3_HUMAN
  • B1AHG4_HUMAN
  • E9PH80_HUMAN
  • F8WEZ7_HUMAN
  • G3V0G2_HUMAN
  • H0Y6F2_HUMAN
genes like me logo Genes that share paralogs with PRR5: view

Variants for PRR5 Gene

Sequence variations from dbSNP and Humsavar for PRR5 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs587777903 not-provided, not provided 44,714,622(+) C/A/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000069395 -- 44,736,733(+) G/T intron_variant
rs1000073712 -- 44,710,389(+) C/G intron_variant
rs1000119494 -- 44,679,896(+) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000120407 -- 44,678,037(+) TGCT/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRR5 Gene

Variant ID Type Subtype PubMed ID
dgv1325e212 CNV loss 25503493
dgv4586n100 CNV loss 25217958
esv1957313 CNV deletion 18987734
esv2657566 CNV deletion 23128226
esv2670519 CNV deletion 23128226
esv2672812 CNV deletion 23128226
esv2724365 CNV deletion 23290073
esv2724366 CNV deletion 23290073
esv2758842 CNV loss 17122850
nsv1073168 CNV deletion 25765185
nsv1136358 CNV deletion 24896259
nsv1136688 CNV deletion 24896259
nsv1144029 CNV deletion 24896259
nsv1160777 CNV duplication 26073780
nsv3650 CNV insertion 18451855
nsv589108 CNV loss 21841781
nsv589109 CNV loss 21841781
nsv817999 CNV gain 17921354
nsv829268 CNV gain 20364138
nsv9916 CNV gain 18304495
nsv9917 CNV loss 18304495

Variation tolerance for PRR5 Gene

Residual Variation Intolerance Score: 51.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.53; 64.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR5 Gene

Disorders for PRR5 Gene

Additional Disease Information for PRR5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PRR5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR5 Gene

Publications for PRR5 Gene

  1. PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling. (PMID: 17599906) Woo SY … Kim DH (The Journal of biological chemistry 2007) 2 3 4 56
  2. PRR5 encodes a conserved proline-rich protein predominant in kidney: analysis of genomic organization, expression, and mutation status in breast and colorectal carcinomas. (PMID: 15718101) Johnstone CN … Rustgi AK (Genomics 2005) 2 3 4 56
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  4. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PMID: 17461779) Pearce LR … Alessi DR (The Biochemical journal 2007) 3 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for PRR5 Gene

Sources for PRR5 Gene