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Aliases for PRR4 Gene

Aliases for PRR4 Gene

  • Proline Rich 4 2 3 5
  • Nasopharyngeal Carcinoma-Associated Proline-Rich Protein 4 3 4
  • Lacrimal Proline-Rich Protein 3 4
  • Proline Rich 4 (Lacrimal) 2 3
  • Proline-Rich Protein 4 3 4
  • PROL4 3 4
  • LPRP 3 4
  • Proline-Rich Polypeptide 4 3

External Ids for PRR4 Gene

Previous HGNC Symbols for PRR4 Gene

  • PROL4

Previous GeneCards Identifiers for PRR4 Gene

  • GC12M010890
  • GC12M010891
  • GC12M010998
  • GC12M010727
  • GC12M010978
  • GC12M012427
  • GC12M010892
  • GC12M011046
  • GC12M011337
  • GC12M011553
  • GC12M011743
  • GC12M011930
  • GC12M012116
  • GC12M012295

Summaries for PRR4 Gene

Entrez Gene Summary for PRR4 Gene

  • This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for PRR4 Gene

PRR4 (Proline Rich 4) is a Protein Coding gene. Diseases associated with PRR4 include Ectodermal Dysplasia-Syndactyly Syndrome 1 and Dry Eye Syndrome. An important paralog of this gene is ENSG00000275778.

Gene Wiki entry for PRR4 Gene

Additional gene information for PRR4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR4 Gene

Genomics for PRR4 Gene

GeneHancer (GH) Regulatory Elements for PRR4 Gene

Promoters and enhancers for PRR4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J011169 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 635.6 -322.0 -322025 4.2 SP1 ZFX NKRF POLR2A ZNF121 ZNF687 ZSCAN21 NFRKB AHR TFE3 PRR4 TAS2R14 ENSG00000256712 ENSG00000275778 PRH1 PRH1-PRR4 SMIM10L1 LINC01252 TAS2R64P TAS2R15P
GH12J010849 Promoter/Enhancer 0.7 EPDnew Ensembl 600.7 -0.4 -425 1 PRR4 TAS2R15P TAS2R7 TAS2R8 ENSG00000256682 TAS2R13 ENSG00000256981 GC12P010842 ENSG00000284826 ENSG00000275778
GH12J011047 Promoter 0.5 EPDnew 600.1 -197.6 -197562 0.1 PRR4 ENSG00000256981 TAS2R50 TAS2R63P TAS2R31 ENSG00000275778 PRH1 PRH1-PRR4 TAS2R14
GH12J010891 Enhancer 1 ENCODE 40.5 -42.7 -42693 1.2 ZNF652 ELF3 CEBPG RERE TFE3 SP1 HNF1A PPARG SP5 ZNF384 PRR4 LINC01252 TAS2R8 TAS2R7 TAS2R12P ENSG00000284826 ENSG00000275778 PRH1 PRH1-PRR4
GH12J010939 Enhancer 0.8 Ensembl ENCODE 24.9 -92.2 -92163 3.5 MAFK ZFX ZNF316 CEBPB NFE2 MAFG NFE2L2 JUND GLIS1 ZEB2 PRR4 LINC01252 GC12M012889 GC12P010929 GC12M012872 ENSG00000275778 PRH1 PRH1-PRR4 TAS2R14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRR4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRR4 gene promoter:
  • Brachyury
  • GCNF
  • GCNF-1
  • GCNF-2
  • NF-kappaB
  • NF-kappaB1
  • Nkx2-5
  • Pbx1a
  • RelA
  • STAT5A

Genomic Locations for PRR4 Gene

Genomic Locations for PRR4 Gene
3,628 bases
Minus strand
346,654 bases
Minus strand

Genomic View for PRR4 Gene

Genes around PRR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR4 Gene

Proteins for PRR4 Gene

  • Protein details for PRR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline-rich protein 4
    Protein Accession:
    Secondary Accessions:
    • A8KA69
    • F5H0D7
    • Q8NFB3

    Protein attributes for PRR4 Gene

    134 amino acids
    Molecular mass:
    15097 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRR4 Gene


neXtProt entry for PRR4 Gene

Post-translational modifications for PRR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRR4 Gene

No data available for DME Specific Peptides for PRR4 Gene

Domains & Families for PRR4 Gene

Gene Families for PRR4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PRR4 Gene


Suggested Antigen Peptide Sequences for PRR4 Gene

GenScript: Design optimal peptide antigens:
  • Nasopharyngeal carcinoma-associated proline-rich protein 4 (PROL4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR4: view

No data available for UniProtKB/Swiss-Prot for PRR4 Gene

Function for PRR4 Gene

genes like me logo Genes that share phenotypes with PRR4: view

Animal Model Products

CRISPR Products

miRNA for PRR4 Gene

miRTarBase miRNAs that target PRR4

Clone Products

  • Applied Biological Materials (abm): Clones for PRR4 - Now 50% OFF >
  • * PRR4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRR4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for PRR4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR4 Gene

Localization for PRR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRR4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR4 gene
Compartment Confidence
extracellular 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space HDA,TAS 22664934
genes like me logo Genes that share ontologies with PRR4: view

Pathways & Interactions for PRR4 Gene

PathCards logo

SuperPathways for PRR4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis HEP 23580065
GO:0007601 visual perception TAS 7544782
genes like me logo Genes that share ontologies with PRR4: view

No data available for Pathways by source and SIGNOR curated interactions for PRR4 Gene

Drugs & Compounds for PRR4 Gene

No Compound Related Data Available

Transcripts for PRR4 Gene

mRNA/cDNA for PRR4 Gene

Unigene Clusters for PRR4 Gene

Proline rich 4 (lacrimal):
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PRR4 - Now 50% OFF >
  • * PRR4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRR4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for PRR4

Alternative Splicing Database (ASD) splice patterns (SP) for PRR4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP5: - - -
SP6: - -

Relevant External Links for PRR4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRR4 Gene

mRNA differential expression in normal tissues according to GTEx for PRR4 Gene

This gene is overexpressed in Minor Salivary Gland (x41.4).

Protein differential expression in normal tissues from HIPED for PRR4 Gene

This gene is overexpressed in Skin (34.4) and Salivary gland (27.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRR4 Gene

Protein tissue co-expression partners for PRR4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRR4 Gene:


SOURCE GeneReport for Unigene cluster for PRR4 Gene:


mRNA Expression by UniProt/SwissProt for PRR4 Gene:

Tissue specificity: Abundantly expressed in lacrimal gland where it is found in the acinar cells but not in the intralobular ducts. Also found in the submandibular gland, the parotid and sublingual glands.

Evidence on tissue expression from TISSUES for PRR4 Gene

  • Eye(5)
  • Blood(4.3)
  • Lung(3.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with PRR4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR4 Gene

Orthologs for PRR4 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRR4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRR4 34
  • 99.5 (n)
Species where no ortholog for PRR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRR4 Gene

Gene Tree for PRR4 (if available)
Gene Tree for PRR4 (if available)
Evolutionary constrained regions (ECRs) for PRR4: view image

Paralogs for PRR4 Gene

genes like me logo Genes that share paralogs with PRR4: view

Variants for PRR4 Gene

Sequence variations from dbSNP and Humsavar for PRR4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000031797 -- 10,848,772(-) A/G intron_variant
rs1000610820 -- 10,845,620(-) T/C downstream_transcript_variant
rs1001867228 -- 10,848,695(-) A/C intron_variant
rs1002375718 -- 10,847,429(-) T/C intron_variant
rs1002462002 -- 10,850,209(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRR4 Gene

Variant ID Type Subtype PubMed ID
esv2759879 CNV loss 17122850
esv3628543 CNV gain 21293372

Variation tolerance for PRR4 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR4 Gene

Disorders for PRR4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRR4 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ectodermal dysplasia-syndactyly syndrome 1
  • edss1
dry eye syndrome
  • xerophthalmia
lacrimal apparatus disease
  • lacrimal apparatus diseases
- elite association - COSMIC cancer census association via MalaCards
Search PRR4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRR4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRR4 Gene

Publications for PRR4 Gene

  1. A major human lacrimal gland mRNA encodes a new proline-rich protein family member. (PMID: 7544782) Dickinson DP … Thiesse M (Investigative ophthalmology & visual science 1995) 2 3 4 23 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for PRR4 Gene

Sources for PRR4 Gene

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