This gene encodes a large protein of unknown function that contains internal regions of low complexity sequence. Alternative splicing results in multiple transcript variants. The transcript structure of the protein-coding variant at this locus is conserved between human and mouse. [provided by RefSeq, Oct 2013] See more...

Aliases for PRR36 Gene

Aliases for PRR36 Gene

  • Proline Rich 36 2 3 5
  • Proline-Rich Protein 36 3 4
  • PRR36 5

External Ids for PRR36 Gene

Summaries for PRR36 Gene

Entrez Gene Summary for PRR36 Gene

  • This gene encodes a large protein of unknown function that contains internal regions of low complexity sequence. Alternative splicing results in multiple transcript variants. The transcript structure of the protein-coding variant at this locus is conserved between human and mouse. [provided by RefSeq, Oct 2013]

GeneCards Summary for PRR36 Gene

PRR36 (Proline Rich 36) is a Protein Coding gene. An important paralog of this gene is BTBD8.

Additional gene information for PRR36 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRR36 Gene

Genomics for PRR36 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRR36 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J007874 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 612 +0.1 89 1.8 PRDM10 RFX1 ZIC2 POLR2A PATZ1 ZNF600 SCRT2 RFX3 KLF9 ZFX PRR36 lnc-PRR36-1 EVI5L NONHSAG024662.2
GH19J007829 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 +44.2 44189 2.4 SP1 CREB1 ATF7 PRDM10 ZNF629 RFX1 LEF1 IKZF1 BACH1 FOS EVI5L ELAVL1 HNRNPM PRR36 LRRC8E piR-32214-337 CLEC4M
GH19J007868 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 +3.8 3789 4.8 ARHGAP35 SP1 CTCF ZBTB33 PRDM10 ZNF629 IKZF1 KDM1A ZNF692 BACH1 ENSG00000268120 NONHSAG024662.2 PRR36 HNRNPM EVI5L TIMM44 lnc-PRR36-1
GH19J007852 Enhancer 1.2 ENCODE dbSUPER 13 +20.9 20884 1.1 HNRNPL GATAD2A CTCF TFE3 LEF1 NFKBIZ RCOR2 JUND MTA2 ZNF143 PRR36 LRRC8E RNA5SP463 EVI5L lnc-PRR36-3 ENSG00000268120
GH19J007896 Enhancer 1 Ensembl ENCODE 12.9 -23.1 -23093 1.1 GATAD2A RCOR2 RXRB IRF2 SP1 CEBPA KMT2B SOX13 ZNF157 ZKSCAN8 PRR36 CTXN1 LRRC8E piR-43939-016 ENSG00000214248 MAP2K7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRR36 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRR36

Genomic Locations for PRR36 Gene

Genomic Locations for PRR36 Gene
chr19:7,868,719-7,874,390
(GRCh38/hg38)
Size:
5,672 bases
Orientation:
Minus strand
chr19:7,933,605-7,939,326
(GRCh37/hg19)
Size:
5,722 bases
Orientation:
Minus strand

Genomic View for PRR36 Gene

Genes around PRR36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR36 Gene

Proteins for PRR36 Gene

  • Protein details for PRR36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6K5-PRR36_HUMAN
    Recommended name:
    Proline-rich protein 36
    Protein Accession:
    Q9H6K5
    Secondary Accessions:
    • A0A087WZ52
    • Q9H3X1

    Protein attributes for PRR36 Gene

    Size:
    1346 amino acids
    Molecular mass:
    132748 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15254.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRR36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRR36 Gene

Post-translational modifications for PRR36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRR36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRR36 Gene

Domains & Families for PRR36 Gene

Gene Families for PRR36 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR36 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with PRR36: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRR36 Gene

Function for PRR36 Gene

Phenotypes From GWAS Catalog for PRR36 Gene

Phenotypes for PRR36 Gene

genes like me logo Genes that share phenotypes with PRR36: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR36

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRR36 Gene

Localization for PRR36 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PRR36 Gene

Pathways & Interactions for PRR36 Gene

PathCards logo

SuperPathways for PRR36 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRR36 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRR36 Gene

Drugs & Compounds for PRR36 Gene

No Compound Related Data Available

Transcripts for PRR36 Gene

mRNA/cDNA for PRR36 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR36

Alternative Splicing Database (ASD) splice patterns (SP) for PRR36 Gene

No ASD Table

Relevant External Links for PRR36 Gene

GeneLoc Exon Structure for
PRR36

Expression for PRR36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRR36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRR36 Gene

This gene is overexpressed in Fetal Brain (57.7) and Frontal cortex (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRR36 Gene



Protein tissue co-expression partners for PRR36 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRR36

genes like me logo Genes that share expression patterns with PRR36: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR36 Gene

Orthologs for PRR36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR36 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 90 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 81 (a)
OneToMany
-- 31
  • 37 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia BC068157 30 31
  • 67.83 (n)
OneToOne
Prr36 17
Rat
(Rattus norvegicus)
Mammalia RGD1566084 30
  • 67.67 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 46 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 44 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 59 (a)
OneToOne
Species where no ortholog for PRR36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PRR36 Gene

ENSEMBL:
Gene Tree for PRR36 (if available)
TreeFam:
Gene Tree for PRR36 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRR36: view image

Paralogs for PRR36 Gene

Paralogs for PRR36 Gene

genes like me logo Genes that share paralogs with PRR36: view

Variants for PRR36 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRR36 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs398122421 Uncertain Significance: not provided 7,870,949(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PRR36 Gene

Additional Variant Information for PRR36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR36

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for PRR36 Gene

Disorders for PRR36 Gene

No disorders were found for PRR36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR36 Gene

Publications for PRR36 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt KT … Blagoev B (Science signaling 2011) 4
  4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V … Han DK (Science signaling 2009) 4
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4

Products for PRR36 Gene

Sources for PRR36 Gene