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Aliases for PRR35 Gene
Aliases for PRR35 Gene
External Ids for PRR35 Gene
- HGNC: 14139
- Entrez Gene: 146325
- Ensembl: ENSG00000161992
- UniProtKB: P0CG20
Previous HGNC Symbols for PRR35 Gene
- C16orf11
Previous GeneCards Identifiers for PRR35 Gene
- GC16P000562
- GC16P001066
- GC16P001110
- GC16P001237
Summaries for PRR35 Gene
GeneCards Summary for PRR35 Gene
PRR35 (Proline Rich 35) is a Protein Coding gene. An important paralog of this gene is ZNF750.
Additional gene information for PRR35 Gene
- HGNC(14139)
- Entrez Gene(146325)
- Ensembl(ENSG00000161992)
- UniProtKB(P0CG20)
- Open Targets Platform(ENSG00000161992)
- Search for PRR35 at DataMed
- Search for PRR35 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRR35 Gene
Genomics for PRR35 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PRR35 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRR35 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRR35
Genomic Locations for PRR35 Gene
Genomic Locations for PRR35 Gene
- chr16:559,786-565,531
- (GRCh38/hg38)
- Size:
- 5,746 bases
- Orientation:
- Plus strand
- chr16:610,422-615,529
- (GRCh37/hg19)
- Size:
- 5,108 bases
- Orientation:
- Plus strand
Genomic View for PRR35 Gene
Genes around PRR35 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.3 by HGNC
- 16p13.3 by Entrez Gene
- 16p13.3 by Ensembl
PRR35 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRR35 Gene
Proteins for PRR35 Gene
-
Protein details for PRR35 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0CG20-PRR35_HUMAN
- Recommended name:
- Proline-rich protein 35
- Protein Accession:
- P0CG20
- B8ZZ27
- Q8N233
- Q96AX3
- Q96S23
Protein attributes for PRR35 Gene
- Size:
- 571 amino acids
- Molecular mass:
- 59354 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAK61234.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for PRR35 Gene
Post-translational modifications for PRR35 Gene
Other Protein References for PRR35 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PRR35
- Invitrogen Antibodies for PRR35 (AFLGC-PRR35)
Protein Products
-
OriGene Purified Proteins for PRR35
- Search Origene for MassSpec and Protein Over-expression Lysates for PRR35
- Origene Custom Protein Services for PRR35
No data available for DME Specific Peptides for PRR35 Gene
Domains & Families for PRR35 Gene
Gene Families for PRR35 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PRR35 Gene
- InterPro:
- ProtoNet:
No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRR35 Gene
Function for PRR35 Gene
Phenotypes From GWAS Catalog for PRR35 Gene
Phenotypes for PRR35 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PRR35 - Select products 50% OFF >
- * PRR35 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PRR35
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRR35
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRR35
miRNA for PRR35 Gene
- miRTarBase miRNAs that target PRR35
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRR35
- Browse OriGene Inhibitory RNA Products For PRR35
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR35
Clone Products
- Applied Biological Materials (abm): Clones for PRR35 - Select products 50% OFF >
- * PRR35 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PRR35
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRR35
Cell Line Products
-
Horizon Cell Lines for PRR35
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR35 Gene
Localization for PRR35 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| mitochondrion | 1 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRR35 Gene
Pathways & Interactions for PRR35 Gene
Interacting Proteins for PRR35 Gene
Selected Interacting proteins:
P0CG20-PRR35_HUMAN
ENSP00000386499
for PRR35 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PRR35
No data available for Pathways by source and SIGNOR curated interactions for PRR35 Gene
Transcripts for PRR35 Gene
mRNA/cDNA for PRR35 Gene
- 1 REFSEQ mRNAs :
- 1 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000409413 2245 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PRR35 - Select products 50% OFF >
- * PRR35 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PRR35
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRR35
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRR35
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRR35
- Browse OriGene Inhibitory RNA Products For PRR35
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR35
Clone Products
- Applied Biological Materials (abm): Clones for PRR35 - Select products 50% OFF >
- * PRR35 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PRR35
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRR35
Relevant External Links for PRR35 Gene
- GeneLoc Exon Structure for
- PRR35
Expression for PRR35 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRR35 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRR35
Primer Products
-
OriGene qPCR primer pairs for PRR35
-
OriGene qPCR primer pairs and template standards for PRR35
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR35 Gene
Orthologs for PRR35 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | C16H16orf11 30 |
|
||
| C16orf11 31 |
|
OneToOne | |||
| Dog (Canis familiaris) |
Mammalia | C6H16orf11 30 |
|
||
| C16orf11 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | C25H16orf11 30 |
|
||
| C16orf11 31 |
|
OneToOne | |||
| Rat (Rattus norvegicus) |
Mammalia | LOC302999 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | A930017K11Rik 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | C16orf11 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | C16orf11 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | C16orf11 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13681 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | C24H16orf11 31 |
|
OneToOne |
- Species where no ortholog for PRR35 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PRR35 Gene
- ENSEMBL:
- Gene Tree for PRR35 (if available)
- TreeFam:
- Gene Tree for PRR35 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRR35: view image
Paralogs for PRR35 Gene
Variants for PRR35 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4817n54 | CNV | gain | 21841781 |
| dgv4818n54 | CNV | loss | 21841781 |
| dgv4819n54 | CNV | gain+loss | 21841781 |
| dgv4821n54 | CNV | gain | 21841781 |
| dgv4822n54 | CNV | loss | 21841781 |
| dgv4823n54 | CNV | loss | 21841781 |
| esv2422427 | CNV | duplication | 17116639 |
| esv25069 | CNV | loss | 19812545 |
| nsv1070731 | CNV | deletion | 25765185 |
| nsv1143795 | CNV | deletion | 24896259 |
| nsv1160325 | CNV | duplication | 26073780 |
| nsv457304 | CNV | gain | 19166990 |
| nsv471063 | CNV | loss | 18288195 |
| nsv471064 | CNV | gain | 18288195 |
| nsv526903 | CNV | loss | 19592680 |
| nsv528354 | CNV | loss | 19592680 |
| nsv570988 | CNV | gain | 21841781 |
| nsv571006 | CNV | gain | 21841781 |
| nsv833113 | CNV | loss | 17160897 |
| nsv833114 | CNV | gain+loss | 17160897 |
| nsv952898 | CNV | deletion | 24416366 |
Gene Damage Index Score:
3.92;
59.48% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRR35 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRR35
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRR35 Gene
Disorders for PRR35 Gene
Additional Disease Information for PRR35
No disorders were found for PRR35 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR35 Gene
Publications for PRR35 Gene
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
- RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
- The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
ExternalLinks
Products for PRR35 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PRR35
- Search Origene for MassSpec and Protein Over-expression Lysates for PRR35
- Origene Custom Protein Services for PRR35
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRR35
- Browse OriGene Inhibitory RNA Products For PRR35
- OriGene qPCR primer pairs for PRR35
- OriGene qPCR primer pairs and template standards for PRR35
- OriGene CRISPR knockouts for PRR35
- OriGene ORF clones in human for PRR35
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PRR35
- Sino Biological Human cDNA Clone for PRR35
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PRR35
- Novus Biologicals proteins and lysates for PRR35
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for PRR35 (AFLGC-PRR35)
- VectorBuilder Custom and pre-made DNA vectors for PRR35 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PRR35 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PRR35 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PRR35 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PRR35
- Horizon Cell Lines for PRR35
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRR35
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRR35
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PRR35
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR35
Sources for PRR35 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB