Aliases for PRR35 Gene

Aliases for PRR35 Gene

  • Proline Rich 35 2 3 5
  • Proline-Rich Protein 35 3 4
  • C16orf11 3 4
  • Chromosome 16 Open Reading Frame 11 2
  • Uncharacterized Protein RJD1 4
  • LA16c-366D1.2 3
  • PRR35 5

External Ids for PRR35 Gene

Previous HGNC Symbols for PRR35 Gene

  • C16orf11

Previous GeneCards Identifiers for PRR35 Gene

  • GC16P000562
  • GC16P001066
  • GC16P001110
  • GC16P001237

Summaries for PRR35 Gene

GeneCards Summary for PRR35 Gene

PRR35 (Proline Rich 35) is a Protein Coding gene. An important paralog of this gene is ZNF750.

Additional gene information for PRR35 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRR35 Gene

Genomics for PRR35 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRR35 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J000558 Enhancer 0.8 Ensembl 600.7 -1.2 -1225 0.7 HNRNPL GATAD2A TFE3 ZIC2 RBFOX2 RXRB IRF2 SP1 GABPA SOX13 PRR35 WFIKKN1 ENSG00000261691 CAPN15
GH16J000560 Promoter 0.8 EPDnew Ensembl 600.7 +0.6 615 0.8 EZH2 NRF1 PRR35 WFIKKN1 LOC107987233
GH16J000559 Enhancer 0.6 Ensembl 600.7 -0.6 -585 0.4 HNRNPL RBFOX2 EZH2 ZNF600 RNF2 PCBP1 ZGPAT MXD4 KDM1A KLF1 PRR35 WFIKKN1 ENSG00000261691 CAPN15
GH16J000523 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13 -32.0 -31995 7.6 SP1 HNRNPL CREB1 PRDM10 ZNF629 SIX5 IKZF1 ZNF692 POLR2A BACH1 CAPN15 LINC00235 lnc-RAB11FIP3-1 lnc-RAB11FIP3-2 UNKL UBE2I CHTF18 TELO2 NHLRC4 ENSG00000268836
GH16J000586 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.6 +31.3 31346 8.4 SP1 CREB1 GATAD2A HNRNPL PRDM10 ZNF629 TFE3 IKZF1 NFKBIZ ZNF692 RAB40C lnc-METTL26-7 WDR90 ENSG00000261505 ENSG00000260051 WASH4P RHOT2 WFIKKN1 TELO2 ENSG00000260954
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRR35 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRR35

Genomic Locations for PRR35 Gene

Genomic Locations for PRR35 Gene
5,746 bases
Plus strand
5,108 bases
Plus strand

Genomic View for PRR35 Gene

Genes around PRR35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR35 Gene

Proteins for PRR35 Gene

  • Protein details for PRR35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline-rich protein 35
    Protein Accession:
    Secondary Accessions:
    • B8ZZ27
    • Q8N233
    • Q96AX3
    • Q96S23

    Protein attributes for PRR35 Gene

    571 amino acids
    Molecular mass:
    59354 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK61234.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PRR35 Gene

Post-translational modifications for PRR35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRR35 Gene

No data available for DME Specific Peptides for PRR35 Gene

Domains & Families for PRR35 Gene

Gene Families for PRR35 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR35 Gene

genes like me logo Genes that share domains with PRR35: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRR35 Gene

Function for PRR35 Gene

Phenotypes From GWAS Catalog for PRR35 Gene

genes like me logo Genes that share phenotypes with PRR35: view

Animal Model Products

CRISPR Products

miRNA for PRR35 Gene

miRTarBase miRNAs that target PRR35

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR35

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR35 Gene

Localization for PRR35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR35 gene
Compartment Confidence
nucleus 2
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRR35 Gene

Pathways & Interactions for PRR35 Gene

PathCards logo

SuperPathways for PRR35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRR35 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRR35 Gene

Drugs & Compounds for PRR35 Gene

No Compound Related Data Available

Transcripts for PRR35 Gene

mRNA/cDNA for PRR35 Gene

1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR35

Alternative Splicing Database (ASD) splice patterns (SP) for PRR35 Gene

No ASD Table

Relevant External Links for PRR35 Gene

GeneLoc Exon Structure for

Expression for PRR35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRR35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRR35 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRR35 Gene

Protein tissue co-expression partners for PRR35 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRR35

genes like me logo Genes that share expression patterns with PRR35: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR35 Gene

Orthologs for PRR35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C16H16orf11 30
  • 98.48 (n)
C16orf11 31
  • 97 (a)
(Canis familiaris)
Mammalia C6H16orf11 30
  • 77.8 (n)
C16orf11 31
  • 70 (a)
(Bos Taurus)
Mammalia C25H16orf11 30
  • 77.23 (n)
C16orf11 31
  • 67 (a)
(Rattus norvegicus)
Mammalia LOC302999 30
  • 74.72 (n)
(Mus musculus)
Mammalia A930017K11Rik 31
  • 65 (a)
(Monodelphis domestica)
Mammalia C16orf11 31
  • 29 (a)
(Gallus gallus)
Aves C16orf11 31
  • 34 (a)
(Anolis carolinensis)
Reptilia C16orf11 31
  • 38 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13681 30
(Danio rerio)
Actinopterygii C24H16orf11 31
  • 25 (a)
Species where no ortholog for PRR35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PRR35 Gene

Gene Tree for PRR35 (if available)
Gene Tree for PRR35 (if available)
Evolutionary constrained regions (ECRs) for PRR35: view image

Paralogs for PRR35 Gene

Paralogs for PRR35 Gene Pseudogenes for PRR35 Gene

genes like me logo Genes that share paralogs with PRR35: view

Variants for PRR35 Gene

Additional dbSNP identifiers (rs#s) for PRR35 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRR35 Gene

Variant ID Type Subtype PubMed ID
dgv4817n54 CNV gain 21841781
dgv4818n54 CNV loss 21841781
dgv4819n54 CNV gain+loss 21841781
dgv4821n54 CNV gain 21841781
dgv4822n54 CNV loss 21841781
dgv4823n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv25069 CNV loss 19812545
nsv1070731 CNV deletion 25765185
nsv1143795 CNV deletion 24896259
nsv1160325 CNV duplication 26073780
nsv457304 CNV gain 19166990
nsv471063 CNV loss 18288195
nsv471064 CNV gain 18288195
nsv526903 CNV loss 19592680
nsv528354 CNV loss 19592680
nsv570988 CNV gain 21841781
nsv571006 CNV gain 21841781
nsv833113 CNV loss 17160897
nsv833114 CNV gain+loss 17160897
nsv952898 CNV deletion 24416366

Variation tolerance for PRR35 Gene

Gene Damage Index Score: 3.92; 59.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRR35 Gene

Disorders for PRR35 Gene

No disorders were found for PRR35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR35 Gene

Publications for PRR35 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for PRR35 Gene

Sources for PRR35 Gene