Aliases for PRR35 Gene
Aliases for PRR35 Gene
External Ids for PRR35 Gene
- HGNC: 14139
- Entrez Gene: 146325
- Ensembl: ENSG00000161992
- UniProtKB: P0CG20
Previous HGNC Symbols for PRR35 Gene
- C16orf11
Summaries for PRR35 Gene
GeneCards Summary for PRR35 Gene
PRR35 (Proline Rich 35) is a Protein Coding gene. An important paralog of this gene is ZNF750.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR35 Gene
Genomics for PRR35 Gene
GeneHancer (GH) Regulatory Elements for PRR35 Gene
Promoters and enhancers for PRR35 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PRR35 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PRR35 Gene
Genomic Locations for PRR35 Gene
- chr16:560,422-565,529
- (GRCh38/hg38)
- Size:
- 5,108 bases
- Orientation:
- Plus strand
- chr16:610,422-615,529
- (GRCh37/hg19)
- Size:
- 5,108 bases
- Orientation:
- Plus strand
Genomic View for PRR35 Gene
Genes around PRR35 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.3 by Entrez Gene
- 16p13.3 by HGNC
- 16p13.3 by Ensembl
PRR35 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRR35 Gene
Proteins for PRR35 Gene
-
Protein details for PRR35 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0CG20-PRR35_HUMAN
- Recommended name:
- Proline-rich protein 35
- Protein Accession:
- P0CG20
- B8ZZ27
- Q8N233
- Q96AX3
- Q96S23
Protein attributes for PRR35 Gene
- Size:
- 571 amino acids
- Molecular mass:
- 59354 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAK61234.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for PRR35 Gene
Post-translational modifications for PRR35 Gene
Other Protein References for PRR35 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PRR35
- Invitrogen Antibodies for PRR35 (AFLGC-PRR35)
- Search GeneTex for Antibodies for PRR35
Protein Products
-
OriGene Purified Proteins for PRR35
- Search Origene for MassSpec and Protein Over-expression Lysates for PRR35
- Origene Custom Protein Services for PRR35
- Search GeneTex for Proteins for PRR35
Assay Products
No data available for DME Specific Peptides for PRR35 Gene
Domains & Families for PRR35 Gene
Gene Families for PRR35 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PRR35 Gene
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PRR35 Gene
Function for PRR35 Gene
Phenotypes From GWAS Catalog for PRR35 Gene
Phenotypes for PRR35 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRR35
-
CRISPR Products
-
OriGene CRISPR knockouts for PRR35
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRR35
- genomics-online: gRNA clones - Search results for available C16ORF11 gene related products
- Applied Biological Materials CRISPR for PRR35
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRR35
- GenScript: Design CRISPR guide RNA sequences for PRR35
miRNA for PRR35 Gene
- miRTarBase miRNAs that target PRR35
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRR35
- Browse OriGene Inhibitory RNA Products For PRR35
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR35
- genomics-online: shRNA clones - Search results for available C16ORF11 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PRR35
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRR35
- genomics-online: cdna clones - Search results for available C16ORF11 gene related products
- orf clones - Search results for available C16ORF11 gene related products
- Applied Biological Materials Clones for PRR35
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PRR35
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR35 Gene
Localization for PRR35 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRR35 Gene
Transcripts for PRR35 Gene
mRNA/cDNA for PRR35 Gene
- (4) REFSEQ mRNAs :
- (7) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000409413 2216 bps (uc002chk.4)
CRISPR Products
-
OriGene CRISPR knockouts for PRR35
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRR35
- genomics-online: gRNA clones - Search results for available C16ORF11 gene related products
- Applied Biological Materials CRISPR for PRR35
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRR35
- GenScript: Design CRISPR guide RNA sequences for PRR35
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRR35
- Browse OriGene Inhibitory RNA Products For PRR35
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR35
- genomics-online: shRNA clones - Search results for available C16ORF11 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PRR35
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PRR35
- genomics-online: cdna clones - Search results for available C16ORF11 gene related products
- orf clones - Search results for available C16ORF11 gene related products
- Applied Biological Materials Clones for PRR35
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PRR35 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRR35 Gene
NURSA nuclear receptor signaling pathways regulating expression of PRR35 Gene:
PRR35Primer Products
-
OriGene qPCR primer pairs for PRR35
-
OriGene qPCR primer pairs and template standards for PRR35
- genomics-online: primer clones - Search results for available C16ORF11 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR35 Gene
Orthologs for PRR35 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C16H16orf11 33 |
|
||
| C16orf11 34 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C6H16orf11 33 |
|
||
| C16orf11 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C25H16orf11 33 |
|
||
| C16orf11 34 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | LOC302999 33 |
|
||
| mouse (Mus musculus) |
Mammalia | A930017K11Rik 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | C16orf11 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C16orf11 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | C16orf11 34 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13681 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | C24H16orf11 34 |
|
OneToOne |
- Species where no ortholog for PRR35 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PRR35 Gene
- ENSEMBL:
- Gene Tree for PRR35 (if available)
- TreeFam:
- Gene Tree for PRR35 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PRR35: view image
Paralogs for PRR35 Gene
Pseudogenes.org Pseudogenes for PRR35 Gene
Variants for PRR35 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000534543 | -- | 558,398(+) | T/C | upstream_transcript_variant | |
| rs1000902641 | -- | 557,937(+) | T/G | upstream_transcript_variant | |
| rs1001073010 | -- | 562,539(+) | A/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1001145577 | -- | 562,873(+) | T/C | intron_variant | |
| rs1001632883 | -- | 558,345(+) | C/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4817n54 | CNV | gain | 21841781 |
| dgv4818n54 | CNV | loss | 21841781 |
| dgv4819n54 | CNV | gain+loss | 21841781 |
| dgv4821n54 | CNV | gain | 21841781 |
| dgv4822n54 | CNV | loss | 21841781 |
| dgv4823n54 | CNV | loss | 21841781 |
| esv2422427 | CNV | duplication | 17116639 |
| esv25069 | CNV | loss | 19812545 |
| nsv1070731 | CNV | deletion | 25765185 |
| nsv1143795 | CNV | deletion | 24896259 |
| nsv1160325 | CNV | duplication | 26073780 |
| nsv457304 | CNV | gain | 19166990 |
| nsv471063 | CNV | loss | 18288195 |
| nsv471064 | CNV | gain | 18288195 |
| nsv526903 | CNV | loss | 19592680 |
| nsv528354 | CNV | loss | 19592680 |
| nsv570988 | CNV | gain | 21841781 |
| nsv571006 | CNV | gain | 21841781 |
| nsv833113 | CNV | loss | 17160897 |
| nsv833114 | CNV | gain+loss | 17160897 |
| nsv952898 | CNV | deletion | 24416366 |
Gene Damage Index Score:
3.92;
59.48% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PRR35 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRR35
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR35 Gene
Disorders for PRR35 Gene
Additional Disease Information for PRR35
No disorders were found for PRR35 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR35 Gene
Publications for PRR35 Gene
- RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
- The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
- Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 4 58
Products for PRR35 Gene
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- Invitrogen Antibodies for PRR35 (AFLGC-PRR35)
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- genomics-online: cdna clones - Search results for available C16ORF11 gene related products
- orf clones - Search results for available C16ORF11 gene related products
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PRR35
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Sources for PRR35 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt