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Aliases for PRR34 Gene

Aliases for PRR34 Gene

  • Proline Rich 34 2 3 5
  • C22orf26 3 4
  • Chromosome 22 Open Reading Frame 26 2
  • Proline-Rich Protein 34 3

External Ids for PRR34 Gene

Previous HGNC Symbols for PRR34 Gene

  • C22orf26

Summaries for PRR34 Gene

GeneCards Summary for PRR34 Gene

PRR34 (Proline Rich 34) is a Protein Coding gene.

Additional gene information for PRR34 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR34 Gene

Genomics for PRR34 Gene

GeneHancer (GH) Regulatory Elements for PRR34 Gene

Promoters and enhancers for PRR34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I046049 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 555.6 -18.6 -18596 45.7 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 SIN3A FEZF1 ZNF2 IRF4 YY1 LOC642648 PRR34 CDPF1 TRMU LINC00899 ATXN10 ENSG00000273243 ENSG00000273287 FAM118A TTC38
GH22I046006 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 12.5 +43.4 43403 9.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 LINC00899 CDPF1 TRMU ENSG00000273243 LOC642648 PRR34 PRR34-AS1 MIRLET7BHG ENSG00000231010 NUP50
GH22I046000 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.1 +51.7 51685 3.1 BCOR HDAC1 KLF17 ZMYM3 ZIC2 ZFHX2 GLIS2 ZBTB48 PATZ1 PRDM10 LINC00899 LOC642648 MIRLET7BHG PRR34 PRR34-AS1 ENSG00000231010 GC22M045913 LOC730668
GH22I046022 Enhancer 0.9 ENCODE dbSUPER 12.7 +30.3 30276 1.8 ZBTB21 KLF17 SALL2 ZNF398 ZIC2 HIC1 ZNF664 ZFHX2 JUND ZNF366 LINC00899 LOC642648 PRR34-AS1 ENSG00000231010 MIRLET7BHG PRR34 ENSG00000273287 ENSG00000273145 GC22M046033
GH22I046004 Enhancer 0.7 ENCODE dbSUPER 12.1 +49.6 49647 0.7 GLIS1 ZMYM3 KDM1A FOS LINC00899 LOC642648 MIRLET7BHG PRR34 PRR34-AS1 ENSG00000231010 GC22M045913 LOC730668
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRR34 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRR34 Gene

Genomic Locations for PRR34 Gene
chr22:46,049,478-46,054,144
(GRCh38/hg38)
Size:
4,667 bases
Orientation:
Minus strand
chr22:46,445,358-46,450,024
(GRCh37/hg19)

Genomic View for PRR34 Gene

Genes around PRR34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR34 Gene

Proteins for PRR34 Gene

  • Protein details for PRR34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV39-PRR34_HUMAN
    Recommended name:
    Proline-rich protein 34
    Protein Accession:
    Q9NV39
    Secondary Accessions:
    • B0QZ24

    Protein attributes for PRR34 Gene

    Size:
    138 amino acids
    Molecular mass:
    14718 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRR34 Gene

Post-translational modifications for PRR34 Gene

No Post-translational modifications

Other Protein References for PRR34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRR34 Gene

Domains & Families for PRR34 Gene

Gene Families for PRR34 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR34 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR34: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PRR34 Gene

Function for PRR34 Gene

Phenotypes From GWAS Catalog for PRR34 Gene

genes like me logo Genes that share phenotypes with PRR34: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRR34 Gene

Localization for PRR34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR34 gene
Compartment Confidence
extracellular 3
mitochondrion 2
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRR34 Gene

Pathways & Interactions for PRR34 Gene

SuperPathways for PRR34 Gene

No Data Available

Interacting Proteins for PRR34 Gene

Selected Interacting proteins: Q9NV39-PRR34_HUMAN for PRR34 Gene via UniProtKB

Symbol External ID(s) Details
PRR20D

Gene Ontology (GO) - Biological Process for PRR34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRR34 Gene

Drugs & Compounds for PRR34 Gene

No Compound Related Data Available

Transcripts for PRR34 Gene

mRNA/cDNA for PRR34 Gene

(1) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR34 Gene

No ASD Table

Relevant External Links for PRR34 Gene

GeneLoc Exon Structure for
PRR34
ECgene alternative splicing isoforms for
PRR34

Expression for PRR34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRR34 Gene

Protein differential expression in normal tissues from HIPED for PRR34 Gene

This gene is overexpressed in Colon muscle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRR34 Gene



Protein tissue co-expression partners for PRR34 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRR34 Gene:

PRR34
genes like me logo Genes that share expression patterns with PRR34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR34 Gene

Orthologs for PRR34 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRR34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C22orf26 34
  • 99 (a)
OneToOne
Species where no ortholog for PRR34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRR34 Gene

ENSEMBL:
Gene Tree for PRR34 (if available)
TreeFam:
Gene Tree for PRR34 (if available)

Paralogs for PRR34 Gene

No data available for Paralogs for PRR34 Gene

Variants for PRR34 Gene

Sequence variations from dbSNP and Humsavar for PRR34 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000038221 -- 46,055,899(-) C/T upstream_transcript_variant
rs1000244289 -- 46,055,550(-) G/C upstream_transcript_variant
rs1000343247 -- 46,051,169(-) G/A 3_prime_UTR_variant
rs1000572035 -- 46,054,291(-) T/C upstream_transcript_variant
rs1000894972 -- 46,050,516(-) C/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for PRR34 Gene

Variant ID Type Subtype PubMed ID
dgv2469n106 OTHER inversion 24896259
dgv776n67 CNV gain 20364138
dgv777n67 CNV gain 20364138
nsv1152661 OTHER inversion 26484159
nsv471212 CNV loss 18288195
nsv829281 CNV gain 20364138
nsv829285 CNV gain 20364138
nsv829289 CNV loss 20364138

Variation tolerance for PRR34 Gene

Gene Damage Index Score: 2.52; 43.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR34

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR34 Gene

Disorders for PRR34 Gene

Additional Disease Information for PRR34

No disorders were found for PRR34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR34 Gene

Publications for PRR34 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4 58

Products for PRR34 Gene

Sources for PRR34 Gene

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