Aliases for PRR3 Gene

Aliases for PRR3 Gene

  • Proline Rich 3 2 3 5
  • CAT56 2 3 4
  • MHC Class I Region Proline-Rich Protein CAT56 3 4
  • Proline-Rich Protein 3 3 4
  • Proline-Rich Polypeptide 3 3
  • Proline-Rich Polpeptide 3 2
  • Em:AB014077.1 2
  • Em:AB023052.2 2
  • PRR3 5

External Ids for PRR3 Gene

Previous GeneCards Identifiers for PRR3 Gene

  • GC06P030295
  • GC06P030630
  • GC06P030632
  • GC06P030524
  • GC06P030324
  • GC06P030557
  • GC06P032277
  • GC06P032467
  • GC06P032578
  • GC06P033362
  • GC06P030567
  • GC06P030719
  • GC06P030772
  • GC06P030898
  • GC06P031056
  • GC06P031205
  • GC06P031412
  • GC06P032051

Summaries for PRR3 Gene

GeneCards Summary for PRR3 Gene

PRR3 (Proline Rich 3) is a Protein Coding gene. An important paralog of this gene is PPP1R10.

Additional gene information for PRR3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRR3 Gene

Genomics for PRR3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRR3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRR3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRR3

Top Transcription factor binding sites by QIAGEN in the PRR3 gene promoter:
  • AREB6
  • C/EBPalpha
  • Egr-3
  • Pax-4a
  • Pax-5
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for PRR3 Gene

Genomic Locations for PRR3 Gene
chr6:30,556,709-30,563,723
(GRCh38/hg38)
Size:
7,015 bases
Orientation:
Plus strand
chr6:30,524,486-30,532,473
(GRCh37/hg19)
Size:
7,988 bases
Orientation:
Plus strand

Genomic View for PRR3 Gene

Genes around PRR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for PRR3 Gene

  • Protein details for PRR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P79522-PRR3_HUMAN
    Recommended name:
    Proline-rich protein 3
    Protein Accession:
    P79522
    Secondary Accessions:
    • A1A4H4
    • Q5RJB5
    • Q5STN6

    Protein attributes for PRR3 Gene

    Size:
    188 amino acids
    Molecular mass:
    20640 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB40147.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PRR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRR3 Gene

Post-translational modifications for PRR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRR3 Gene

Domains & Families for PRR3 Gene

Gene Families for PRR3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR3 Gene

InterPro:
Blocks:
  • Zn-finger, C-x8-C-x5-C-x3-H type
ProtoNet:

Suggested Antigen Peptide Sequences for PRR3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ95224, Homo sapiens proline rich 3 (PRR3), mRNA (A6NDA2_HUMAN)
  • MHC class I region proline-rich protein CAT56 (PRR3_HUMAN)
  • cDNA FLJ60784, highly similar to Proline-rich protein 3 (Q96QB9_HUMAN)
genes like me logo Genes that share domains with PRR3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRR3 Gene

Function for PRR3 Gene

Phenotypes From GWAS Catalog for PRR3 Gene

Gene Ontology (GO) - Molecular Function for PRR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PRR3: view
genes like me logo Genes that share phenotypes with PRR3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR3 Gene

Localization for PRR3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR3 gene
Compartment Confidence
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRR3 Gene

Pathways & Interactions for PRR3 Gene

PathCards logo

SuperPathways for PRR3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRR3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRR3 Gene

Drugs & Compounds for PRR3 Gene

No Compound Related Data Available

Transcripts for PRR3 Gene

mRNA/cDNA for PRR3 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR3 Gene

No ASD Table

Relevant External Links for PRR3 Gene

GeneLoc Exon Structure for
PRR3

Expression for PRR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRR3 Gene

Protein differential expression in normal tissues from HIPED for PRR3 Gene

This gene is overexpressed in Ovary (38.6), Retina (13.0), and Fetal testis (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PRR3 Gene



Protein tissue co-expression partners for PRR3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRR3

SOURCE GeneReport for Unigene cluster for PRR3 Gene:

Hs.118354

Evidence on tissue expression from TISSUES for PRR3 Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with PRR3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR3 Gene

Orthologs for PRR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRR3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRR3 30 31
  • 98.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PRR3 30 31
  • 91.27 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 91 (a)
OneToMany
LOC608835 30
  • 90.25 (n)
-- 31
  • 86 (a)
OneToMany
-- 31
  • 84 (a)
OneToMany
-- 31
  • 74 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Prr3 30
  • 85.84 (n)
Mouse
(Mus musculus)
Mammalia Prr3 30 17 31
  • 85.46 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta PNUTS 31
  • 3 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8858 31
  • 6 (a)
OneToMany
Species where no ortholog for PRR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PRR3 Gene

ENSEMBL:
Gene Tree for PRR3 (if available)
TreeFam:
Gene Tree for PRR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRR3: view image

Paralogs for PRR3 Gene

Paralogs for PRR3 Gene

(1) SIMAP similar genes for PRR3 Gene using alignment to 1 proteins:

  • PRR3_HUMAN

Pseudogenes.org Pseudogenes for PRR3 Gene

genes like me logo Genes that share paralogs with PRR3: view

Variants for PRR3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRR3 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs3888778 - p.Gly61Ser

Additional dbSNP identifiers (rs#s) for PRR3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRR3 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781

Variation tolerance for PRR3 Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR3 Gene

Disorders for PRR3 Gene

Additional Disease Information for PRR3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for PRR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR3 Gene

Publications for PRR3 Gene

  1. HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia. (PMID: 19912639) Paladini F … Sorrentino R (Arthritis research & therapy 2009) 3 41
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 41
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

Products for PRR3 Gene

Sources for PRR3 Gene