Aliases for PRR26 Gene

Aliases for PRR26 Gene

  • Proline Rich 26 2 3 5
  • Proline-Rich Protein 26 3 4
  • C10orf108 3 4
  • Chromosome 10 Open Reading Frame 108 2
  • HSALNG0075495 167
  • NONHSAG004962 92
  • Lnc-GTPBP4-1 168
  • Lnc-PRR26-5 168

External Ids for PRR26 Gene

Previous HGNC Symbols for PRR26 Gene

  • C10orf108

Previous GeneCards Identifiers for PRR26 Gene

  • GC10P000696

Summaries for PRR26 Gene

GeneCards Summary for PRR26 Gene

PRR26 (Proline Rich 26) is a Protein Coding gene. Diseases associated with PRR26 include Hepatocellular Carcinoma.

Additional gene information for PRR26 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRR26 Gene

Genomics for PRR26 Gene

GeneHancer (GH) Regulatory Elements for PRR26 Gene

Promoters and enhancers for PRR26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J000649 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 500.7 +0.5 518 2.5 POLR2G NCOR1 ZIC2 KDM6A ZBTB25 TGIF2 TBX3 ZSCAN9 FOXA2 NR2F2 PRR26 ENSG00000225140 DIP2C lnc-LARP4B-3
GH10J000623 Enhancer 1.3 ENCODE CraniofacialAtlas dbSUPER 12.1 -24.7 -24690 3 NRF1 USF1 TEAD4 FOS ZNF639 ZNF10 ZIC2 ZNF423 TOE1 TEAD1 LOC101930421 PRR26 DIP2C ENSG00000225140
GH10J000612 Enhancer 1.1 ENCODE CraniofacialAtlas dbSUPER 12 -35.4 -35376 4.3 ZNF217 FOS GATAD2B CTBP1 MXI1 SIN3A MYC ZNF592 MBD2 POLR2A PRR26 DIP2C TUBB8 LOC101930421 piR-49402
GH10J000593 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.2 -55.8 -55788 1.3 FOS ZBTB17 NFE2 ZBTB48 RXRA HNF4A BHLHE40 YY1 ZNF24 NFE2L2 PRR26 DIP2C piR-49402 LOC101930421
GH10J000597 Enhancer 0.8 ENCODE dbSUPER 12.5 -50.9 -50866 4.1 FOS FOXA2 JUND RAD21 RXRA HNF4A BHLHE40 REST FOXA1 MAZ ENSG00000225140 PRR26 DIP2C TUBB8 piR-49402 LOC101930421
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRR26 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRR26

Genomic Locations for PRR26 Gene

Genomic Locations for PRR26 Gene
chr10:649,948-669,581
(GRCh38/hg38)
Size:
19,634 bases
Orientation:
Plus strand
chr10:695,888-711,109
(GRCh37/hg19)
Size:
15,222 bases
Orientation:
Plus strand

Genomic View for PRR26 Gene

Genes around PRR26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR26 Gene

Proteins for PRR26 Gene

  • Protein details for PRR26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8Z3-PRR26_HUMAN
    Recommended name:
    Proline-rich protein 26
    Protein Accession:
    Q8N8Z3

    Protein attributes for PRR26 Gene

    Size:
    221 amino acids
    Molecular mass:
    24207 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRR26 Gene

Post-translational modifications for PRR26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRR26 Gene

Domains & Families for PRR26 Gene

Gene Families for PRR26 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR26 Gene

ProtoNet:
genes like me logo Genes that share domains with PRR26: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRR26 Gene

Function for PRR26 Gene

Phenotypes for PRR26 Gene

genes like me logo Genes that share phenotypes with PRR26: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR26

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR26 Gene

Localization for PRR26 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR26 gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRR26 Gene

Pathways & Interactions for PRR26 Gene

PathCards logo

SuperPathways for PRR26 Gene

No Data Available

Interacting Proteins for PRR26 Gene

;

Gene Ontology (GO) - Biological Process for PRR26 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRR26 Gene

Drugs & Compounds for PRR26 Gene

No Compound Related Data Available

Transcripts for PRR26 Gene

mRNA/cDNA for PRR26 Gene

5 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
7 RNACentral transcripts :
1 NONCODE transcripts :
1 LncBook transcripts :
2 LNCipedia transcripts :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR26

Alternative Splicing Database (ASD) splice patterns (SP) for PRR26 Gene

No ASD Table

Relevant External Links for PRR26 Gene

GeneLoc Exon Structure for
PRR26

Expression for PRR26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRR26 Gene

mRNA differential expression in normal tissues according to GTEx for PRR26 Gene

This gene is overexpressed in Colon - Sigmoid (x5.6).

Protein differential expression in normal tissues from HIPED for PRR26 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRR26 Gene



Protein tissue co-expression partners for PRR26 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRR26

SOURCE GeneReport for Unigene cluster for PRR26 Gene:

Hs.587103
genes like me logo Genes that share expression patterns with PRR26: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR26 Gene

Orthologs for PRR26 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRR26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR26 31
  • 98 (a)
OneToOne
Species where no ortholog for PRR26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRR26 Gene

ENSEMBL:
Gene Tree for PRR26 (if available)
TreeFam:
Gene Tree for PRR26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRR26: view image

Paralogs for PRR26 Gene

No data available for Paralogs for PRR26 Gene

Variants for PRR26 Gene

Additional dbSNP identifiers (rs#s) for PRR26 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRR26 Gene

Variant ID Type Subtype PubMed ID
dgv118n67 CNV gain 20364138
dgv340e59 CNV duplication 20981092
dgv651n100 CNV gain 25217958
esv1255045 CNV deletion 17803354
esv21741 CNV gain 19812545
esv2537541 CNV insertion 19546169
esv2660097 CNV deletion 23128226
esv2728618 CNV deletion 23290073
esv2728629 CNV deletion 23290073
nsv1069437 CNV deletion 25765185
nsv1120210 CNV tandem duplication 24896259
nsv1140441 CNV tandem duplication 24896259
nsv1146678 CNV insertion 26484159
nsv24219 CNV deletion 16902084
nsv528733 CNV gain 19592680
nsv549751 CNV gain 21841781
nsv549753 CNV gain 21841781
nsv549764 CNV loss 21841781

Variation tolerance for PRR26 Gene

Gene Damage Index Score: 1.69; 32.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR26

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRR26 Gene

Disorders for PRR26 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRR26 Gene - From: LncRNADisease

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search PRR26 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRR26

genes like me logo Genes that share disorders with PRR26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRR26 Gene

Publications for PRR26 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for PRR26 Gene

Sources for PRR26 Gene