Aliases for PRR25 Gene

Aliases for PRR25 Gene

  • Proline Rich 25 2 3
  • Proline-Rich Protein 25 3 4
  • Gs64 2 3

External Ids for PRR25 Gene

Previous GeneCards Identifiers for PRR25 Gene

  • GC16P000802
  • GC16P000855
  • GC16P000779
  • GC16P000822
  • GC16P000866
  • GC16P001062
  • GC16P001104
  • GC16P001137
  • GC16P001261
  • GC16P000889
  • GC16P000905
  • GC16P000923
  • GC16P000940
  • GC16P000961
  • GC16P000989
  • GC16P001011
  • GC16P001034

Summaries for PRR25 Gene

GeneCards Summary for PRR25 Gene

PRR25 (Proline Rich 25) is a Protein Coding gene. Diseases associated with PRR25 include Cardiomyopathy, Familial Hypertrophic, 1.

Additional gene information for PRR25 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRR25 Gene

Genomics for PRR25 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRR25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J000804 Enhancer 0.5 Ensembl 600.7 -1.0 -1042 0.8 ZNF692 ZNF600 ZNF341 ZNF266 ZNF335 ZFP69B KLF10 CTCF PRR25 ENSG00000261505 ENSG00000260051 RHOT2 ENSG00000260954 TELO2 SPSB3 AXIN1 WASH4P CRAMP1
GH16J000803 Enhancer 0.3 Ensembl 600.7 -1.7 -1742 0.2 POLR2A PRR25 CHTF18 GNG13
GH16J000806 Promoter/Enhancer 1.5 ENCODE CraniofacialAtlas 0.7 +2.3 2302 1.9 SP1 CREB1 HNRNPL PRDM10 ZNF629 SIX5 IKZF1 POLR2A ZHX2 ETV6 MN297337 lnc-GNG13-6 CHTF18 ENSG00000261207 MSLN PRR25 LOC107984876
GH16J000813 Enhancer 0.7 CraniofacialAtlas 0.4 +8.3 8258 0.2 CTCF REST RAD21 ZNF561 SMARCA5 USF1 NR2C2 SMC3 KLF4 YY1 RF00017-1922 ENSG00000287855 PRR25 LOC107984876
GH16J000824 Enhancer 0.7 Ensembl CraniofacialAtlas 0.4 +20.0 19958 1.2 ZNF692 MNT SP2 ZBTB17 NFIC EZH2 KLF1 L3MBTL2 ZBTB6 ZBTB8A ENSG00000287855 PRR25 ENSG00000275438 LOC107984876
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRR25 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRR25

Genomic Locations for PRR25 Gene

Genomic Locations for PRR25 Gene
8,419 bases
Plus strand
8,419 bases
Plus strand

Genomic View for PRR25 Gene

Genes around PRR25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR25 Gene

Proteins for PRR25 Gene

  • Protein details for PRR25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline-rich protein 25
    Protein Accession:

    Protein attributes for PRR25 Gene

    402 amino acids
    Molecular mass:
    40998 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRR25 Gene

Post-translational modifications for PRR25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRR25 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for PRR25 Gene

Domains & Families for PRR25 Gene

Gene Families for PRR25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR25 Gene


Suggested Antigen Peptide Sequences for PRR25 Gene

GenScript: Design optimal peptide antigens:
  • Proline-rich protein 25 (PRR25_HUMAN)
genes like me logo Genes that share domains with PRR25: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRR25 Gene

Function for PRR25 Gene

Phenotypes From GWAS Catalog for PRR25 Gene

Phenotypes for PRR25 Gene

GenomeRNAi human phenotypes for PRR25:
genes like me logo Genes that share phenotypes with PRR25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR25

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRR25 Gene

Localization for PRR25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR25 gene
Compartment Confidence
cytoskeleton 1
nucleus 1
cytosol 1
plasma membrane 0
extracellular 0
mitochondrion 0
peroxisome 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRR25 Gene

Pathways & Interactions for PRR25 Gene

PathCards logo

SuperPathways for PRR25 Gene

No Data Available

Interacting Proteins for PRR25 Gene

Gene Ontology (GO) - Biological Process for PRR25 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRR25 Gene

Drugs & Compounds for PRR25 Gene

No Compound Related Data Available

Transcripts for PRR25 Gene

mRNA/cDNA for PRR25 Gene


CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR25

Alternative Splicing Database (ASD) splice patterns (SP) for PRR25 Gene

No ASD Table

Relevant External Links for PRR25 Gene

GeneLoc Exon Structure for

Expression for PRR25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRR25 Gene

Protein differential expression in normal tissues from HIPED for PRR25 Gene

This gene is overexpressed in Prostate (50.9) and Testis (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRR25 Gene

Protein tissue co-expression partners for PRR25 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRR25

SOURCE GeneReport for Unigene cluster for PRR25 Gene:

genes like me logo Genes that share expression patterns with PRR25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR25 Gene

Orthologs for PRR25 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRR25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRR25 30
  • 95.79 (n)
Species where no ortholog for PRR25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

No data available for Evolution for PRR25 Gene

Paralogs for PRR25 Gene

No data available for Paralogs for PRR25 Gene

Variants for PRR25 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRR25 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs1005190 - p.Thr92Ser
rs13337837 - p.Pro249Leu

Additional dbSNP identifiers (rs#s) for PRR25 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRR25 Gene

Variant ID Type Subtype PubMed ID
dgv4827n54 CNV loss 21841781
dgv4828n54 CNV gain 21841781
esv2422427 CNV duplication 17116639
esv3570042 CNV gain 25503493
esv3637582 CNV gain 21293372
esv3637584 CNV loss 21293372
esv3637585 CNV gain 21293372
esv3637586 CNV loss 21293372
esv3637587 CNV gain 21293372
esv3637588 CNV loss 21293372
nsv1160325 CNV duplication 26073780
nsv471063 CNV loss 18288195
nsv517488 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571042 CNV loss 21841781
nsv571045 CNV gain 21841781
nsv817712 CNV loss 17921354
nsv952898 CNV deletion 24416366

Variation tolerance for PRR25 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.24; 92.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR25 Gene

Disorders for PRR25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRR25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cardiomyopathy, familial hypertrophic, 1
  • fhc
- elite association - COSMIC cancer census association via MalaCards
Search PRR25 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRR25

genes like me logo Genes that share disorders with PRR25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRR25 Gene

Publications for PRR25 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 2 3 4
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4

Products for PRR25 Gene

Sources for PRR25 Gene