Aliases for PRR23B Gene

Aliases for PRR23B Gene

  • Proline Rich 23B 2 3 5
  • Proline-Rich Protein 23B 3 4
  • FLJ46116 2
  • PRR23B 5

External Ids for PRR23B Gene

Previous GeneCards Identifiers for PRR23B Gene

  • GC03M140222
  • GC03M138737
  • GC03M136113

Summaries for PRR23B Gene

GeneCards Summary for PRR23B Gene

PRR23B (Proline Rich 23B) is a Protein Coding gene. Diseases associated with PRR23B include Familial Isolated Trichomegaly. An important paralog of this gene is PRR23A.

Additional gene information for PRR23B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRR23B Gene

Genomics for PRR23B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PRR23B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J139187 Enhancer 0.5 FANTOM5 4 -167.0 -166993 0.1 REST USF1 ZNF407 TOE1 RAD51 CTCF USF2 CBFA2T2 PRR23A PRR23B PRR23C piR-58308-220 piR-48553-202 MRPS22 COPB2
GH03J139363 Enhancer 0.2 FANTOM5 7.8 -342.6 -342565 0.4 COPB2 ENSG00000248932 PRR23A PRR23B PRR23C ENSG00000272656 lnc-RBP2-2 piR-57133-434
GH03J139394 Enhancer 0.7 FANTOM5 Ensembl 1.2 -373.3 -373274 0.8 ZNF512 HMBOX1 CEBPG TAL1 CEBPB MEIS2 USF2 TEAD4 CBFA2T3 ARID1B ENSG00000272656 ACTG1P1 PRR23C PRR23B COPB2 ENSG00000248932 LOC100507291 piR-46854 RBP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRR23B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PRR23B

Genomic Locations for PRR23B Gene

Genomic Locations for PRR23B Gene
chr3:139,019,031-139,020,926
(GRCh38/hg38)
Size:
1,896 bases
Orientation:
Minus strand
chr3:138,737,873-138,739,768
(GRCh37/hg19)
Size:
1,896 bases
Orientation:
Minus strand

Genomic View for PRR23B Gene

Genes around PRR23B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR23B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR23B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR23B Gene

Proteins for PRR23B Gene

  • Protein details for PRR23B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRT6-PR23B_HUMAN
    Recommended name:
    Proline-rich protein 23B
    Protein Accession:
    Q6ZRT6
    Secondary Accessions:
    • B2RNV9

    Protein attributes for PRR23B Gene

    Size:
    265 amino acids
    Molecular mass:
    28269 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRR23B Gene

Post-translational modifications for PRR23B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRR23B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRR23B Gene

Domains & Families for PRR23B Gene

Gene Families for PRR23B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR23B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRR23B Gene

GenScript: Design optimal peptide antigens:
  • Proline-rich protein 23B (PR23B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZRT6

UniProtKB/Swiss-Prot:

PR23B_HUMAN :
  • Belongs to the PRR23 family.
Family:
  • Belongs to the PRR23 family.
genes like me logo Genes that share domains with PRR23B: view

Function for PRR23B Gene

Phenotypes From GWAS Catalog for PRR23B Gene

genes like me logo Genes that share phenotypes with PRR23B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR23B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRR23B Gene

Localization for PRR23B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR23B gene
Compartment Confidence
mitochondrion 2
plasma membrane 1
nucleus 1
cytosol 1
peroxisome 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRR23B Gene

Pathways & Interactions for PRR23B Gene

PathCards logo

SuperPathways for PRR23B Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRR23B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRR23B Gene

Drugs & Compounds for PRR23B Gene

No Compound Related Data Available

Transcripts for PRR23B Gene

mRNA/cDNA for PRR23B Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR23B

Alternative Splicing Database (ASD) splice patterns (SP) for PRR23B Gene

No ASD Table

Relevant External Links for PRR23B Gene

GeneLoc Exon Structure for
PRR23B

Expression for PRR23B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRR23B Gene

mRNA differential expression in normal tissues according to GTEx for PRR23B Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for PRR23B Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRR23B Gene



Protein tissue co-expression partners for PRR23B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRR23B

SOURCE GeneReport for Unigene cluster for PRR23B Gene:

Hs.531376
genes like me logo Genes that share expression patterns with PRR23B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR23B Gene

Orthologs for PRR23B Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRR23B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PRR23B 30 31
  • 99.37 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 57 (a)
ManyToMany
-- 31
  • 57 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 52 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Prr23a 31
  • 46 (a)
ManyToMany
Gm6406 31
  • 45 (a)
ManyToMany
2410012M07Rik 31
  • 44 (a)
ManyToMany
Species where no ortholog for PRR23B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PRR23B Gene

ENSEMBL:
Gene Tree for PRR23B (if available)
TreeFam:
Gene Tree for PRR23B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRR23B: view image

Paralogs for PRR23B Gene

Paralogs for PRR23B Gene

(2) SIMAP similar genes for PRR23B Gene using alignment to 1 proteins:

  • PR23B_HUMAN
genes like me logo Genes that share paralogs with PRR23B: view

Variants for PRR23B Gene

Additional dbSNP identifiers (rs#s) for PRR23B Gene

Structural Variations from Database of Genomic Variants (DGV) for PRR23B Gene

Variant ID Type Subtype PubMed ID
esv3569022 CNV loss 25503493
nsv591854 CNV gain 21841781
nsv591855 CNV loss 21841781
nsv829736 CNV gain 17160897

Variation tolerance for PRR23B Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR23B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR23B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PRR23B Gene

Disorders for PRR23B Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRR23B Gene - From: DISEASES

Disorder Aliases PubMed IDs
familial isolated trichomegaly
  • tcmgly
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with PRR23B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRR23B Gene

Publications for PRR23B Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan JA … Goldberg AL (The EMBO journal 2013) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for PRR23B Gene

Sources for PRR23B Gene