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Aliases for PRR22 Gene

Aliases for PRR22 Gene

  • Proline Rich 22 2 3 5
  • Proline-Rich Protein 22 3 4

External Ids for PRR22 Gene

Previous GeneCards Identifiers for PRR22 Gene

  • GC19M005735
  • GC19M005543

Summaries for PRR22 Gene

GeneCards Summary for PRR22 Gene

PRR22 (Proline Rich 22) is a Protein Coding gene.

Additional gene information for PRR22 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR22 Gene

Genomics for PRR22 Gene

GeneHancer (GH) Regulatory Elements for PRR22 Gene

Promoters and enhancers for PRR22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J006055 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.1 -277.7 -277745 13.7 ZNF652 ZFX SP1 CC2D1A ELF3 ZKSCAN8 CBFA2T2 ZNF148 MLLT1 CEBPG RFX2 ACSBG2 DUS3L PRR22 SAFB SNRPEP4 SLC25A41 KHSRP CATSPERD DENND1C
GH19J005850 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 11.7 -66.1 -66087 2.1 ZKSCAN8 CEBPG RNF2 CEBPA ZEB2 PATZ1 CEBPB SCRT2 ZBTB17 ATF3 FUT3 NRTN DUS3L PRR22 CATSPERD LOC101928844
GH19J005826 Enhancer 1.3 ENCODE dbSUPER 12.2 -43.3 -43283 3.5 CC2D1A ELF3 ZFX MNT ZNF148 POLR2A MLLT1 ZNF121 CEBPG RERE DUS3L ENSG00000267571 VMAC KHSRP NDUFA11 PTPRS RANBP3 PRR22 SAFB CATSPERD
GH19J005956 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 8 -178.5 -178487 13.9 ZNF652 SP1 CTCF ELF3 MNT CEBPG RERE ZSCAN21 MAFK TFE3 VMAC ENSG00000267571 CAPS DUS3L NDUFA11 GPR108 FUT5 ACSBG2 SAFB KDM4B
GH19J005773 Enhancer 0.9 ENCODE 0.4 +10.9 10888 1.2 CTCF MNT CEBPG ZNF384 MYC SP7 RAD21 SMARCA4 KAT8 RXRA PRR22 GC19M005749 CATSPERD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRR22 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRR22 Gene

Genomic Locations for PRR22 Gene
chr19:5,782,960-5,784,765
(GRCh38/hg38)
Size:
1,806 bases
Orientation:
Minus strand
chr19:5,782,971-5,784,776
(GRCh37/hg19)
Size:
1,806 bases
Orientation:
Minus strand

Genomic View for PRR22 Gene

Genes around PRR22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR22 Gene

Proteins for PRR22 Gene

  • Protein details for PRR22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ63-PRR22_HUMAN
    Recommended name:
    Proline-rich protein 22
    Protein Accession:
    Q8IZ63
    Secondary Accessions:
    • E9PB31

    Protein attributes for PRR22 Gene

    Size:
    422 amino acids
    Molecular mass:
    43980 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08985.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAH23278.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=EAW69147.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PRR22 Gene

Post-translational modifications for PRR22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRR22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRR22 Gene

Domains & Families for PRR22 Gene

Gene Families for PRR22 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRR22 Gene

GenScript: Design optimal peptide antigens:
  • Proline-rich protein 22 (PRR22_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR22: view

No data available for UniProtKB/Swiss-Prot for PRR22 Gene

Function for PRR22 Gene

Phenotypes From GWAS Catalog for PRR22 Gene

genes like me logo Genes that share phenotypes with PRR22: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PRR22 - Now 50% OFF >
  • * PRR22 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRR22 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRR22 Gene

Localization for PRR22 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR22 gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRR22 Gene

Pathways & Interactions for PRR22 Gene

PathCards logo

SuperPathways for PRR22 Gene

No Data Available

Interacting Proteins for PRR22 Gene

Gene Ontology (GO) - Biological Process for PRR22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRR22 Gene

Drugs & Compounds for PRR22 Gene

No Compound Related Data Available

Transcripts for PRR22 Gene

mRNA/cDNA for PRR22 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for PRR22 Gene

Proline rich 22:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for PRR22 - Now 50% OFF >
  • * PRR22 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * PRR22 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for PRR22 Gene

No ASD Table

Relevant External Links for PRR22 Gene

GeneLoc Exon Structure for
PRR22
ECgene alternative splicing isoforms for
PRR22

Expression for PRR22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRR22 Gene

Protein differential expression in normal tissues from HIPED for PRR22 Gene

This gene is overexpressed in Plasma (38.3), Testis (16.8), and Heart (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRR22 Gene



Protein tissue co-expression partners for PRR22 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRR22 Gene:

PRR22

SOURCE GeneReport for Unigene cluster for PRR22 Gene:

Hs.631838
genes like me logo Genes that share expression patterns with PRR22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR22 Gene

Orthologs for PRR22 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRR22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR22 35 34
  • 98.03 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRR22 35 34
  • 77.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRR22 35 34
  • 76.51 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prr22 17 35 34
  • 68.98 (n)
rat
(Rattus norvegicus)
Mammalia Prr22 34
  • 68.58 (n)
Species where no ortholog for PRR22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRR22 Gene

ENSEMBL:
Gene Tree for PRR22 (if available)
TreeFam:
Gene Tree for PRR22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PRR22: view image

Paralogs for PRR22 Gene

No data available for Paralogs for PRR22 Gene

Variants for PRR22 Gene

Sequence variations from dbSNP and Humsavar for PRR22 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000014187 -- 5,783,656(-) G/A coding_sequence_variant, synonymous_variant
rs1001565377 -- 5,786,289(-) C/G upstream_transcript_variant
rs1001804489 -- 5,785,683(-) G/A upstream_transcript_variant
rs1003477091 -- 5,784,919(-) C/A upstream_transcript_variant
rs1003526643 -- 5,784,774(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRR22 Gene

Variant ID Type Subtype PubMed ID
nsv1062851 CNV gain 25217958
nsv470119 CNV loss 18288195
nsv525707 CNV loss 19592680

Variation tolerance for PRR22 Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.62; 89.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR22

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR22 Gene

Disorders for PRR22 Gene

Additional Disease Information for PRR22

No disorders were found for PRR22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR22 Gene

Publications for PRR22 Gene

  1. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 4 58

Products for PRR22 Gene

Sources for PRR22 Gene

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