Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRR21 Gene

Aliases for PRR21 Gene

  • Proline Rich 21 2 3
  • Putative Proline-Rich Protein 21 3

External Ids for PRR21 Gene

Previous GeneCards Identifiers for PRR21 Gene

  • GC02M240630
  • GC02M240981
  • GC02M232739

Summaries for PRR21 Gene

GeneCards Summary for PRR21 Gene

PRR21 (Proline Rich 21) is a Protein Coding gene.

Additional gene information for PRR21 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR21 Gene

Genomics for PRR21 Gene

GeneHancer (GH) Regulatory Elements for PRR21 Gene

Promoters and enhancers for PRR21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J240134 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.6 -93.0 -92959 2.5 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF48 ETS1 POLR2B E2F8 ELK1 COPS9 ANKMY1 OR6B3 NDUFA10 PRR21 CAPN10 OR5S1P GC02P240095
GH02J239926 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.3 +115.4 115350 2 GLIS2 CBX5 FOS ATF7 SP3 ATF4 MAFF SMARCA4 KLF1 ZIC2 NDUFA10 OR6B3 PRR21 GC02P239934 GC02P239887
GH02J239952 Enhancer 0.9 Ensembl ENCODE dbSUPER 9.9 +89.2 89173 2.5 ZFHX2 POLR2A MNT ZIC2 EGR2 NDUFA10 PRR21 MIR4786 GC02P239934 GC02P239972
GH02J240070 Enhancer 0.7 ENCODE 11.6 -27.1 -27087 0.1 NCOA3 CLOCK ESRRA NFIB NEUROD1 SIN3A NFXL1 CEBPG ZKSCAN1 RFX5 PRR21 OR6B2 NDUFA10 OR9S24P GC02M240027
GH02J240319 Enhancer 0.8 Ensembl ENCODE 9.3 -277.3 -277343 2.2 ZNF777 BACH1 ZIC2 NR2F2 GLIS2 ZFHX2 EGR1 FOS EGR2 PRR21 ENSG00000276366 LOC102723825
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PRR21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRR21 gene promoter:
  • Roaz
  • GATA-2
  • Nkx2-5
  • RORalpha2
  • ER-alpha
  • USF-1
  • USF1
  • ATF6
  • MZF-1
  • SEF-1 (1)

Genomic Locations for PRR21 Gene

Genomic Locations for PRR21 Gene
chr2:240,041,813-240,042,982
(GRCh38/hg38)
Size:
1,170 bases
Orientation:
Minus strand
chr2:240,981,230-240,982,399
(GRCh37/hg19)
Size:
1,170 bases
Orientation:
Minus strand

Genomic View for PRR21 Gene

Genes around PRR21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for PRR21 Gene

Proteins for PRR21 Gene

Post-translational modifications for PRR21 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PRR21 Gene

Domains & Families for PRR21 Gene

Gene Families for PRR21 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PRR21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR21: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for PRR21 Gene

Function for PRR21 Gene

Phenotypes From GWAS Catalog for PRR21 Gene

genes like me logo Genes that share phenotypes with PRR21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR21

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRR21 Gene

Localization for PRR21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR21 gene
Compartment Confidence
mitochondrion 2
nucleus 2
extracellular 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRR21 Gene

Pathways & Interactions for PRR21 Gene

SuperPathways for PRR21 Gene

No Data Available

Interacting Proteins for PRR21 Gene

Gene Ontology (GO) - Biological Process for PRR21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRR21 Gene

Drugs & Compounds for PRR21 Gene

No Compound Related Data Available

Transcripts for PRR21 Gene

mRNA/cDNA for PRR21 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-

Unigene Clusters for PRR21 Gene

Proline rich 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR21

Alternative Splicing Database (ASD) splice patterns (SP) for PRR21 Gene

No ASD Table

Relevant External Links for PRR21 Gene

GeneLoc Exon Structure for
PRR21
ECgene alternative splicing isoforms for
PRR21

Expression for PRR21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRR21 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRR21 Gene:

PRR21

SOURCE GeneReport for Unigene cluster for PRR21 Gene:

Hs.693479
genes like me logo Genes that share expression patterns with PRR21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR21 Gene

Orthologs for PRR21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR21 Gene

Organism Taxonomy Gene Similarity Type Details
zebrafish
(Danio rerio)
Actinopterygii LOC101882432 33
  • 64.53 (n)
Species where no ortholog for PRR21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

No data available for Evolution for PRR21 Gene

Paralogs for PRR21 Gene

No data available for Paralogs for PRR21 Gene

Variants for PRR21 Gene

Sequence variations from dbSNP and Humsavar for PRR21 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000947530 -- 240,044,857(-) G/A upstream_transcript_variant
rs1000980086 -- 240,044,541(-) G/A upstream_transcript_variant
rs1002286375 -- 240,044,244(-) C/T upstream_transcript_variant
rs1002813229 -- 240,044,028(-) C/G upstream_transcript_variant
rs1003989276 -- 240,043,838(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRR21 Gene

Variant ID Type Subtype PubMed ID
esv2556078 CNV deletion 19546169
esv26039 CNV loss 19812545
esv2721888 CNV deletion 23290073
esv3594790 CNV loss 21293372
esv3893576 CNV loss 25118596
nsv10225 CNV loss 18304495
nsv3236 CNV insertion 18451855
nsv511846 CNV loss 21212237
nsv525278 CNV gain 19592680
nsv584801 CNV gain 21841781
nsv997288 CNV gain 25217958

Variation tolerance for PRR21 Gene

Gene Damage Index Score: 9.87; 89.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR21

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR21 Gene

Disorders for PRR21 Gene

Additional Disease Information for PRR21

No disorders were found for PRR21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR21 Gene

Publications for PRR21 Gene

No publications were found for PRR21 Gene.

Products for PRR21 Gene

Sources for PRR21 Gene

Content
Loading form....