Aliases for PRR21 Gene

Aliases for PRR21 Gene

  • Proline Rich 21 2 3
  • Putative Proline-Rich Protein 21 3

External Ids for PRR21 Gene

Previous GeneCards Identifiers for PRR21 Gene

  • GC02M240630
  • GC02M240981
  • GC02M232739
  • GC02M240041

Summaries for PRR21 Gene

GeneCards Summary for PRR21 Gene

PRR21 (Proline Rich 21) is a Protein Coding gene. Diseases associated with PRR21 include Bardet-Biedl Syndrome 4 and West Syndrome.

Additional gene information for PRR21 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PRR21 Gene

Genomics for PRR21 Gene

GeneHancer (GH) Regulatory Elements Pubs


Top Transcription factor binding sites by QIAGEN in the PRR21 gene promoter:
  • ATF6
  • ER-alpha
  • GATA-2
  • MZF-1
  • Nkx2-5
  • Roaz
  • RORalpha2
  • SEF-1 (1)
  • USF-1
  • USF1

Genomic Locations for PRR21 Gene

Genomic Locations for PRR21 Gene
chr2:-
(GRCh38/hg38)
Orientation:
Unknown strand
chr2:240,981,230-240,982,399
(GRCh37/hg19)
Size:
1,170 bases
Orientation:
Minus strand

Genomic View for PRR21 Gene


Cytogenetic band:
GeneLoc Logo Gene Density

No data available for RefSeq DNA sequence for PRR21 Gene

Proteins for PRR21 Gene

Post-translational modifications for PRR21 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PRR21 Gene

Domains & Families for PRR21 Gene

Suggested Antigen Peptide Sequences for PRR21 Gene

GenScript: Design optimal peptide antigens:
  • Putative proline-rich protein 21 (PRR21_HUMAN)

No data available for Gene Families , Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PRR21 Gene

Function for PRR21 Gene

Phenotypes for PRR21 Gene

genes like me logo Genes that share phenotypes with PRR21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR21

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRR21 Gene

Localization for PRR21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR21 gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRR21 Gene

Pathways & Interactions for PRR21 Gene

PathCards logo

SuperPathways for PRR21 Gene

No Data Available

Interacting Proteins for PRR21 Gene

Gene Ontology (GO) - Biological Process for PRR21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRR21 Gene

Drugs & Compounds for PRR21 Gene

No Compound Related Data Available

Transcripts for PRR21 Gene

mRNA/cDNA for PRR21 Gene

1 REFSEQ mRNAs :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PRR21

Alternative Splicing Database (ASD) splice patterns (SP) for PRR21 Gene

No ASD Table

Expression for PRR21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRR21 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PRR21

SOURCE GeneReport for Unigene cluster for PRR21 Gene:

Hs.693479
genes like me logo Genes that share expression patterns with PRR21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR21 Gene

Orthologs for PRR21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR21 Gene

Organism Taxonomy Gene Similarity Type Details
Zebrafish
(Danio rerio)
Actinopterygii LOC101882432 30
  • 64.53 (n)
Species where no ortholog for PRR21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

No data available for Evolution for PRR21 Gene

Paralogs for PRR21 Gene

No data available for Paralogs for PRR21 Gene

Variants for PRR21 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRR21 Gene

Variant ID Type Subtype PubMed ID
esv2556078 CNV deletion 19546169
esv26039 CNV loss 19812545
esv2721888 CNV deletion 23290073
esv3594790 CNV loss 21293372
esv3893576 CNV loss 25118596
nsv10225 CNV loss 18304495
nsv3236 CNV insertion 18451855
nsv511846 CNV loss 21212237
nsv525278 CNV gain 19592680
nsv584801 CNV gain 21841781
nsv997288 CNV gain 25217958

Variation tolerance for PRR21 Gene

Gene Damage Index Score: 9.87; 89.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR21

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Additional dbSNP identifiers (rs#s) for PRR21 Gene

Disorders for PRR21 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRR21 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bardet-biedl syndrome 4
  • bbs4
west syndrome
  • epileptic encephalopathy, early infantile, 1
- elite association - COSMIC cancer census association via MalaCards
Search PRR21 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRR21

genes like me logo Genes that share disorders with PRR21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRR21 Gene

Publications for PRR21 Gene

  1. Loose ends: almost one in five human genes still have unresolved coding status. (PMID: 29982784) Abascal F … Tress ML (Nucleic acids research 2018) 2 3

Products for PRR21 Gene

Sources for PRR21 Gene