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Aliases for PRR18 Gene

Aliases for PRR18 Gene

  • Proline Rich 18 2 3 5
  • Proline Rich Region 18 2

External Ids for PRR18 Gene

Previous GeneCards Identifiers for PRR18 Gene

  • GC06M166639
  • GC06M164190
  • GC06M166719

Summaries for PRR18 Gene

GeneCards Summary for PRR18 Gene

PRR18 (Proline Rich 18) is a Protein Coding gene.

Additional gene information for PRR18 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR18 Gene

Genomics for PRR18 Gene

GeneHancer (GH) Regulatory Elements for PRR18 Gene

Promoters and enhancers for PRR18 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I166307 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 557.2 +0.2 196 1.4 TFAP4 RB1 NR2F1 ARID4B EBF1 ZNF48 POLR2A MXD3 NBN HNF4A PRR18 SFT2D1 PIR38027 GC06P166295
GH06I166308 Enhancer 0.7 ENCODE dbSUPER 555.6 +1.1 1120 0.4 ZNF687 USF1 BACH1 EZH2 PRR18 GC06P166295 PIR38027
GH06I166306 Enhancer 0.6 dbSUPER 550.8 +1.8 1789 0.9 ZNF687 USF1 FOXA2 FOXA3 HLF BACH1 ZNF384 CEBPG NFIL3 RFX3 PRR18 SFT2D1 GC06P166295 PIR38027
GH06I166360 Enhancer 1.2 Ensembl ENCODE 25 -52.5 -52501 1.5 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 TCF12 SLC30A9 ZNF121 GC06M166360 PRR18 MPC1 LOC100289495
GH06I166340 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 11.2 -34.0 -34022 3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B SFT2D1 LOC100289495 MPC1 PRR18 HNRNPA1P49
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRR18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRR18 gene promoter:

Genomic Locations for PRR18 Gene

Genomic Locations for PRR18 Gene
chr6:166,305,300-166,308,448
(GRCh38/hg38)
Size:
3,149 bases
Orientation:
Minus strand
chr6:166,719,168-166,721,936
(GRCh37/hg19)

Genomic View for PRR18 Gene

Genes around PRR18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR18 Gene

Proteins for PRR18 Gene

  • Protein details for PRR18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4B5-PRR18_HUMAN
    Recommended name:
    Proline-rich protein 18
    Protein Accession:
    Q8N4B5

    Protein attributes for PRR18 Gene

    Size:
    295 amino acids
    Molecular mass:
    30926 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRR18 Gene

Post-translational modifications for PRR18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRR18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRR18 Gene

Domains & Families for PRR18 Gene

Gene Families for PRR18 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRR18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR18: view

No data available for UniProtKB/Swiss-Prot for PRR18 Gene

Function for PRR18 Gene

Phenotypes From GWAS Catalog for PRR18 Gene

genes like me logo Genes that share phenotypes with PRR18: view

Animal Model Products

CRISPR Products

miRNA for PRR18 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR18 Gene

Localization for PRR18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR18 gene
Compartment Confidence
nucleus 2
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PRR18 Gene

Pathways & Interactions for PRR18 Gene

SuperPathways for PRR18 Gene

No Data Available

Interacting Proteins for PRR18 Gene

Gene Ontology (GO) - Biological Process for PRR18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRR18 Gene

Drugs & Compounds for PRR18 Gene

No Compound Related Data Available

Transcripts for PRR18 Gene

mRNA/cDNA for PRR18 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRR18 Gene

Proline rich 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR18 Gene

No ASD Table

Relevant External Links for PRR18 Gene

GeneLoc Exon Structure for
PRR18
ECgene alternative splicing isoforms for
PRR18

Expression for PRR18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRR18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRR18 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.3), Brain - Substantia nigra (x6.3), Brain - Hippocampus (x6.2), Brain - Putamen (basal ganglia) (x5.6), Brain - Amygdala (x5.0), and Brain - Hypothalamus (x4.2).

Protein differential expression in normal tissues from HIPED for PRR18 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRR18 Gene



Protein tissue co-expression partners for PRR18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRR18 Gene:

PRR18

SOURCE GeneReport for Unigene cluster for PRR18 Gene:

Hs.731862
genes like me logo Genes that share expression patterns with PRR18: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR18 Gene

Orthologs for PRR18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR18 33 34
  • 99.03 (n)
rat
(Rattus norvegicus)
Mammalia Prr18 33
  • 76.41 (n)
mouse
(Mus musculus)
Mammalia Prr18 33 16 34
  • 75.77 (n)
oppossum
(Monodelphis domestica)
Mammalia PRR18 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prr18 33
  • 46.63 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101885898 33
  • 62.67 (n)
prr18 34
  • 36 (a)
OneToOne
Species where no ortholog for PRR18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRR18 Gene

ENSEMBL:
Gene Tree for PRR18 (if available)
TreeFam:
Gene Tree for PRR18 (if available)

Paralogs for PRR18 Gene

No data available for Paralogs for PRR18 Gene

Variants for PRR18 Gene

Sequence variations from dbSNP and Humsavar for PRR18 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000180262 -- 166,306,982(-) C/T 3_prime_UTR_variant
rs1000233890 -- 166,306,781(-) C/A/T 3_prime_UTR_variant
rs1000964165 -- 166,306,341(-) A/T 3_prime_UTR_variant
rs1000996993 -- 166,305,973(-) G/A 3_prime_UTR_variant
rs1001691589 -- 166,306,444(-) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for PRR18 Gene

Variant ID Type Subtype PubMed ID
nsv823927 CNV gain 20364138

Variation tolerance for PRR18 Gene

Gene Damage Index Score: 0.40; 8.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR18

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR18 Gene

Disorders for PRR18 Gene

Additional Disease Information for PRR18

No disorders were found for PRR18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR18 Gene

Publications for PRR18 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin AI … Ukraintseva SV (Aging 2010) 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4 58

Products for PRR18 Gene

Sources for PRR18 Gene

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